Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation

Science

Volumn 313, Issue 5787, 2006, Pages 670-673

  Kaneko, Yoshikatsu ^a   Nimmerjahn, Falk ^a   Ravetch, Jeffrey V ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CYTOLOGY; DRUG PRODUCTS; IMMUNOLOGY; POLYSACCHARIDES;

ANTI-INFLAMMATORY PROPERTIES; CYTOTOXIC ANTIBODIES; IMMUNOGLOBULIN; SIALYLATION;

PROTEINS;

CYTOTOXIC ANTIBODY; FC RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G;

ANTIBODY; POLYSACCHARIDE; PROTEIN;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; IMMUNE RESPONSE; INFLAMMATION; PRIORITY JOURNAL; SIALYLATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS; ARTHRITIS, RHEUMATOID; GLYCOSYLATION; HALF-LIFE; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULINS, INTRAVENOUS; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; NEPHRITIS; POLYSACCHARIDES; RECEPTORS, FC; RECEPTORS, IGG; SIALIC ACIDS;

EID: 33746888249     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1129594     Document Type: Article

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23. We thank M. Madaio for providing the NTS; C. Bertozzi for helpful discussions and suggestions; A. Datta for glycan analysis; and P. Smith, J. Clowney, A. Kim, and J. Pagan for technical assistance. These studies were supported by grants from NIH (J.V.R.). Y.K. was supported by fellowships from the Naito Foundation, the Kanae Foundation for Life & Sodal-Medical Science, and the Uehara Memorial Foundation. F.N. is a fellow of the Cancer Research Institute.