Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA

Biotechnology and Bioengineering

Volumn 88, Issue 7, 2004, Pages 901-908

  Mori, Katsuhiro ^a   Kuni Kamochi, Reiko ^a   Yamane Ohnuki, Naoko ^a   Wakitani, Masako ^a   Yamano, Kazuya ^a   Imai, Harue ^a   Kanda, Yutaka ^a   Niwa, Rinpei ^a   Iida, Shigeru ^a   Uchida, Kazuhisa ^a   Shitara, Kenya ^a   Satoh, Mitsuo ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

1,6 fucosyltransferase; Antibody dependent cellular cytotoxicity; CHO cells; Fed batch culture; Recombinant antibody production; siRNA

Indexed keywords

ANTIBODIES; CELL CULTURE; CYTOLOGY; RNA; TOXICITY;

CHINESE HAMSTER OVARY CELLS; CYTOTOXICITY; FUCOSYLTRANSFERASE;

CELLS;

ALPHA 1,6 FUCOSYLTRANSFERASE; ANTIBODY; FUCOSYLTRANSFERASE; MESSENGER RNA; OLIGOSACCHARIDE; RECOMBINANT ANTIBODY; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY PRODUCING CELL; ANTIBODY PRODUCTION; ARTICLE; BIOENGINEERING; CHO CELL; CLONE; EFFECTOR CELL; FED BATCH CULTURE; LENTIL; NONHUMAN; PLASMID; PROTEIN EXPRESSION;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; FUCOSYLTRANSFERASES; GENE SILENCING; GENETIC ENHANCEMENT; PROTEIN ENGINEERING; RNA, SMALL INTERFERING;

CRICETINAE; CRICETULUS GRISEUS; LENS CULINARIS;

EID: 10844222497     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20326     Document Type: Article

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