Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: A study of Chinese hamster ovary cells producing a recombinant monoclonal antibody

Cytotechnology

Volumn 64, Issue 1, 2012, Pages 27-41

  Dahodwala, Hussain ^a   Nowey, Mark ^a   Mitina, Tatyana ^b   Sharfstein, Susan T ^c  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b Novozymes Biopharma DK A S   (United Kingdom)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

CHO cells; Insulin; LONG R 3IGF I; Metabolism; Monoclonal antibody

Indexed keywords

AMINO ACID; AMMONIA; GLUCOSE; GLUTAMINE; IMMUNOGLOBULIN G ANTIBODY; INSULIN; LACTIC ACID; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY; RECOMBINANT MONOCLONAL ANTIBODY; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CELL CLONE; CELL DENSITY; CELL GROWTH; CELL METABOLISM; CELL STIMULATION; CELL VIABILITY; CHO CELL; CLONAL VARIATION; METABOLITE; NONHUMAN; NUTRIENT;

CRICETULUS GRISEUS;

EID: 84655161863     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-011-9388-z     Document Type: Article

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