CHO cells in biotechnology for production of recombinant proteins: Current state and further potential

Applied Microbiology and Biotechnology

Volumn 93, Issue 3, 2012, Pages 917-930

  Kim, Jee Yon ^a   Kim, Yeon Gu ^b   Lee, Gyun Min ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Cell engineering; Cell line development; CHO cells; Omics based approaches; Vector engineering

Indexed keywords

CELL ENGINEERING; CELL LINE DEVELOPMENT; CELL LINES; CHINESE HAMSTER OVARY CELLS; CHO CELL; CIS-ACTING ELEMENT; COMMERCIAL PRODUCTIONS; GENE TARGETING; MAMMALIAN HOSTS; MARKET NEEDS; METABOLOMICS; MODULATION STRATEGY; OMICS-BASED APPROACHES; ON CURRENTS; PROTEIN PRODUCTION; PROTEOMICS; RECOMBINANT PROTEIN; SITE-SPECIFIC; THERAPEUTIC PROTEIN; TRANSCRIPTOMICS;

CELLS; ENGINEERING; GENE EXPRESSION; GENETIC ENGINEERING; MAMMALS; MOLECULAR BIOLOGY; PROTEINS;

CELL CULTURE;

AMMONIA; CASPASE; CHAPERONE; CIS ACTING ELEMENT; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BCL 2; RECOMBINANT PROTEIN; SNARE PROTEIN; TRANS ACTING FACTOR; X BOX BINDING PROTEIN 1;

COMMERCIAL ACTIVITY; DISEASE TREATMENT; GENETIC ENGINEERING; OPTIMIZATION; PROTEIN; RECOMBINATION; RODENT; TECHNOLOGICAL DEVELOPMENT;

ANTIBODY PRODUCTION; AUTOPHAGY; BIOTECHNOLOGY; CELL CLONING; CELL CULTURE; CELL CYCLE PROGRESSION; CELL DEATH; CELL ENGINEERING; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL VOLUME; CHO CELL; CLONING VECTOR; CULTURE MEDIUM; DOWN REGULATION; ENDOPLASMIC RETICULUM; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; GROWTH RATE; HIGH THROUGHPUT SCREENING; LONGEVITY; MASS SPECTROMETRY; MEMBRANE FUSION; METABOLIC ENGINEERING; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ONCOGENE C MYC; OSMOLARITY; PH; PROTEIN SYNTHESIS; PROTEIN UNFOLDING; PROTEOMICS; REVIEW; SIGNAL TRANSDUCTION; TEMPERATURE; TRANSCRIPTOMICS; TRANSGENE; UNFOLDED PROTEIN RESPONSE;

ANIMALS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL ENGINEERING; CHO CELLS; CRICETINAE; CRICETULUS; GENE TARGETING; GENETIC VECTORS; HUMANS; RECOMBINANT PROTEINS;

CRICETULUS GRISEUS; MAMMALIA;

EID: 84856389498     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3758-5     Document Type: Review

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