RNA interference technology to improve recombinant protein production in Chinese hamster ovary cells

Biotechnology Advances

Volumn 27, Issue 4, 2009, Pages 417-422

  Wu, Suh Chin ^a,b  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

CHO cell; Gene silencing; Recombinant protein; RNAi

Indexed keywords

APOPTOSIS; BIOPHARMACEUTICALS; CELLULAR FUNCTIONS; CELLULAR METABOLISMS; CELLULAR PATHWAYS; CHINESE HAMSTER OVARY CELLS; CHO CELL; DIHYDROFOLATE REDUCTASE; DOWN REGULATIONS; GENE AMPLIFICATIONS; GENE REGULATIONS; GENE SILENCING; IN CELLS; LACTATE DEHYDROGENASE; MAMMALIAN CELL LINES; MICRORNA; MULTIPLE TARGETS; OTHER APPLICATIONS; PROTEIN GLYCOSYLATION; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN EXPRESSIONS; RECOMBINANT PROTEIN PRODUCTIONS; RNA INTERFERENCES; RNAI; SELF REGULATIONS; SINGLE COMPONENTS; TARGET GENES;

AMPLIFICATION; BIOACTIVITY; CELL CULTURE; CELL DEATH; CELL MEMBRANES; GENE EXPRESSION; MAMMALS; NUCLEIC ACIDS; PROTEINS; RNA; TARGETS;

GENETIC ENGINEERING;

RECOMBINANT PROTEIN;

DRUG; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; METABOLISM; PROTEIN; RNA; RODENT; TECHNOLOGICAL DEVELOPMENT;

ANIMAL; BIOSYNTHESIS; CHO CELL; CRICETULUS; HAMSTER; METHODOLOGY; PROTEIN ENGINEERING; REVIEW; RNA INTERFERENCE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; RNA INTERFERENCE;

CRICETULUS GRISEUS; MAMMALIA;

EID: 67349211749     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2009.03.002     Document Type: Review

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