Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures

Biotechnology Progress

Volumn 28, Issue 3, 2012, Pages 803-813

  Rouiller, Yolande ^a   Périlleux, Arnaud ^a   Marsaut, Milène ^a   Stettler, Matthieu ^a   Vesin, Marie Noëlle ^a   Broly, Hervé ^a  

^a MERCK SERONO S A   (Switzerland)

Author keywords

CHO cell culture; Fc fusion protein; Hydrocortisone; Mifepristone; Sialylation

Indexed keywords

CELL VIABILITY; CELLULAR FUNCTION; CHINESE HAMSTER OVARY CELLS; CHO CELL; COMMERCIAL PRODUCTIONS; DOSE-DEPENDENT; EXTRACELLULAR; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOIDS; HYDROCORTISONE; INHIBITORY EFFECT; MIFEPRISTONE; OPTIMAL CONDITIONS; PREDICTIVE MODELS; PROCESS PERFORMANCE; PROTEIN GLYCOSYLATION; PROTEIN PRODUCTION; SIALIC ACID MOIETY; SIALIDASES; SIALYLATION; SPECIFIC PRODUCTIVITY; TIME-DEPENDENT;

CAPILLARY FLOW; CARBOXYLIC ACIDS; CELL GROWTH; CELL PROLIFERATION; DESIGN OF EXPERIMENTS; ESTERIFICATION; GLYCOSYLATION; GROWTH KINETICS; METABOLISM; PHYSIOLOGY; PROTEINS;

CELL CULTURE;

HYBRID PROTEIN; HYDROCORTISONE; MIFEPRISTONE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CAPILLARY ELECTROPHORESIS; CELL DIVISION; CHO CELL; CRICETULUS; DRUG EFFECT; GLYCOSYLATION; HAMSTER; METABOLISM; SURFACE PLASMON RESONANCE;

ANIMALS; CELL DIVISION; CHO CELLS; CRICETINAE; CRICETULUS; ELECTROPHORESIS, CAPILLARY; GLYCOSYLATION; HYDROCORTISONE; MIFEPRISTONE; RECOMBINANT FUSION PROTEINS; SURFACE PLASMON RESONANCE;

CRICETULUS GRISEUS;

EID: 84862204695     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1530     Document Type: Article

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