A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells

Biotechnology and Bioengineering

Volumn 104, Issue 6, 2009, Pages 1107-1120

  Legmann, Rachel ^a   Schreyer, H Brett ^a,b   Combs, Rodney G ^c   McCormick, Ellen L ^c   Russo, A Peter ^a   Rodgers, Seth T ^a  

^a Seahorse Bioscience   (United States)

^b GENOMATICA INC   (United States)

^c PFIZER INC   (United States)

Author keywords

Bioprocess development; Fed batch parallel micro bioreactors; High throughput cell culture automation; Monoclonal antibody; Quality by design; Scale up

Indexed keywords

BIOPROCESS DEVELOPMENT; FED-BATCH PARALLEL MICRO-BIOREACTORS; HIGH-THROUGHPUT CELL CULTURE AUTOMATION; QUALITY BY DESIGN; SCALE-UP;

ANIMAL CELL CULTURE; BIOCONVERSION; BIOINFORMATICS; BIOREACTORS; CELL CULTURE; CELL MEMBRANES; DENSITY (OPTICAL); DISSOLUTION; DISSOLVED OXYGEN; DISSOLVED OXYGEN SENSORS; EXPERIMENTS; GLUCOSE; MAMMALS; MONOCLONAL ANTIBODIES; QUALITY CONTROL; SURFACE PLASMON RESONANCE; THROUGHPUT;

BATCH CELL CULTURE;

DISSOLVED OXYGEN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CELL CULTURE; CONTROLLED STUDY; EMBRYO; FEMALE; NONHUMAN; OPTICAL DENSITY; PH MEASUREMENT; PROCESS DEVELOPMENT;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; GLUTATHIONE; HYDROGEN-ION CONCENTRATION; OXYGEN; RECOMBINANT PROTEINS;

MAMMALIA;

EID: 70350512964     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22474     Document Type: Article

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