Characterization of the stability of recombinant protein production in the GS-NS0 expression system

Biotechnology and Bioengineering

Volumn 73, Issue 4, 2001, Pages 261-270

  Barnes, Louise M ^a,b   Bentley, Catherine M ^a   Dickson, Alan J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Clonal heterogeneity; GS NS0; Instability; Myeloma; Productivity; Recombinant protein

Indexed keywords

CLONING; CONTINUOUS CELL CULTURE; GROWTH KINETICS;

TRANSFECTANTS;

PROTEINS;

GLUTAMATE AMMONIA LIGASE; INDICATOR; RECOMBINANT PROTEIN;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; GENETIC TRANSFECTION; MAMMAL; MOLECULAR CLONING; MOLECULAR STABILITY; MYELOMA CELL; NONHUMAN; PREDICTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL SURVIVAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC VECTORS; GLUTAMATE-AMMONIA LIGASE; MICE; PLASMACYTOMA; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0035918616     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.1059     Document Type: Article

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