Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines

Biotechnology Journal

Volumn 7, Issue 4, 2012, Pages 516-526

  Doolan, Padraig ^a   Barron, Niall ^a   Kinsella, Paula ^a   Clarke, Colin ^a   Meleady, Paula ^a   O'Sullivan, Finbarr ^a   Melville, Mark ^b,c   Leonard, Mark ^b   Clynes, Martin ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b PFIZER INC   (United States)

^c Percivia LLC   (United States)

Author keywords

Cell specific productivity; Chinese Hamster Ovary (CHO); Microarray; QPCR; S Qp

Indexed keywords

CELL LINES; CHINESE HAMSTER OVARY; EXPRESSION PATTERNS; FED-BATCH CULTURES; FED-BATCH PROCESS; GENE TRANSCRIPTS; LIFE SPAN; MICROARRAY ANALYSIS; MICROARRAY DATA; MICROARRAY EXPRESSIONS; PRODUCTION CELLS; QPCR; S-QP; SPECIFIC PRODUCTIVITY; TOXIC BYPRODUCTS;

BATCH DATA PROCESSING; BYPRODUCTS; GENE EXPRESSION; GENE EXPRESSION REGULATION; MICROARRAYS; POLYMERASE CHAIN REACTION; PRODUCTIVITY;

CELL CULTURE;

BIOLOGICAL MARKER;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; CELL SELECTION; CELL SPECIFICITY; CELL VIABILITY; CHO CELL; FED BATCH CULTURE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; LIFESPAN; MICROARRAY ANALYSIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PRODUCTIVITY; QUANTITATIVE ANALYSIS; SUSTAINED CELL SPECIFIC PRODUCTIVITY; TRANSCRIPTOMICS;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; GENE EXPRESSION; GENE EXPRESSION PROFILING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION;

CRICETULUS GRISEUS;

EID: 84859240257     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201100255     Document Type: Article

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