Metabolite profiling of CHO cells with different growth characteristics

Biotechnology and Bioengineering

Volumn 109, Issue 6, 2012, Pages 1404-1414

  Dietmair, Stefanie ^a   Hodson, Mark P ^a   Quek, Lake Ee ^a   Timmins, Nicholas E ^a,b   Chrysanthopoulos, Panagiotis ^a   Jacob, Shana S ^a   Gray, Peter ^a   Nielsen, Lars K ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Centre for Commercialization of Regenerative Medicine   (Canada)

Author keywords

CHO cells; Media; Metabolomics

Indexed keywords

BIOLOGICAL MECHANISMS; CELL DENSITY; CELLULAR METABOLISM; CHO CELL; CULTURE MEDIUM; EXTRACELLULAR METABOLITES; GROWTH CHARACTERISTIC; GROWTH PERFORMANCE; MAMMALIAN CELL CULTURE; MEDIA; METABOLITE CONCENTRATIONS; METABOLITE PROFILING; METABOLOMICS; MULTIVARIATE DATA ANALYSIS; PHENOTYPIC CHANGES; POST-TRANSLATIONAL MODIFICATIONS; PRODUCT YIELDS; PROTEIN YIELD; REDUCING COSTS; TIME-DEPENDENT CHANGES; VIABLE CELLS;

ANIMAL CELL CULTURE; BIOMOLECULES; CYTOLOGY; GROWTH RATE; METABOLITES; OPTIMIZATION; RATIONAL FUNCTIONS; RECOMBINANT PROTEINS;

CELLS;

2 OXOGLUTARIC ACID; CARBONIC ACID; GLUCONIC ACID; GLUTAMINE; GLYCINE; LACTIC ACID; PHENYLALANINE; PHOSPHORIC ACID; RIBOSE; SUCCINIC ACID; TRYPTOPHAN; TYROSINE; URIDINE DIPHOSPHATE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DENSITY; CELL GROWTH; CELL METABOLISM; CHO CELL; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; EXTRACELLULAR SPACE; GAS CHROMATOGRAPHY; GROWTH RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRACELLULAR SPACE; MASS SPECTROMETER; METABOLITE; METABOLOMICS; NONHUMAN;

ANIMALS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; EPITHELIAL CELLS; METABOLOME;

MAMMALIA;

EID: 84859886034     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24496     Document Type: Article

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