Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: Proteome analysis of the molecular basis for a process-related phenotype

BMC Biotechnology

Volumn 11, Issue , 2011, Pages

  Meleady, Paula ^a   Doolan, Padraig ^a   Henry, Michael ^a   Barron, Niall ^a   Keenan, Joanne ^a   O'Sullivan, Finbar ^a   Clarke, Colin ^a   Gammell, Patrick ^b   Melville, Mark W ^b   Leonard, Mark ^b   Clynes, Martin ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2D DIGE; BIOPROCESSES; CELL LINES; CHINESE HAMSTER OVARY CELLS; CHO CELL; FED BATCHES; GEL ELECTROPHORESIS; HIGH PRODUCTIVITY; LC-MS/MS; MAMMALIAN CELL LINES; MOLECULAR BASIS; PROTEOME ANALYSIS; PROTEOMIC PROFILING; RECOMBINANT PROTEIN; SPECIFIC PRODUCTIVITY; SUSTAINED PRODUCTIVITY;

ANIMAL CELL CULTURE; BATCH CELL CULTURE; CELLS; ELECTROPHORESIS; MAMMALS; MONOCLONAL ANTIBODIES; PRODUCTIVITY;

PROTEINS;

ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALDOSE REDUCTASE RELATED PROTEIN 2; ELONGATION FACTOR 1; ENDOPLASMIN PROTEIN; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 PROTEIN; GLUCOSE 6 PHOSPHATE 1 DEHYDROGENASE; HEAT SHOCK COGNATE 71 KDA PROTEIN; LIPOCORTIN 4; NUCLEAR MIGRATION PROTEIN; P21 ACTIVATED KINASE 2; PHOSPHOGLYCERATE MUTASE 1 PROTEIN; PROTEIN; PROTEOME; RUVB LIKE 1 PROTEIN; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; FEMALE; GEL ELECTROPHORESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OVARY CELL CULTURE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; ANIMAL; BIOTECHNOLOGY; CELL SURVIVAL; CRICETULUS; HAMSTER; METABOLISM; STANDARD; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; WESTERN BLOTTING;

CRICETULUS GRISEUS; MAMMALIA;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; BLOTTING, WESTERN; CELL SURVIVAL; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; GLUCOSEPHOSPHATE DEHYDROGENASE; PHENOTYPE; PROTEOME; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY; TWO-DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

EID: 79960570244     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-78     Document Type: Article

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