Recombinant protein therapeutics from CHO Cells - 20 years and counting

Chemical Engineering Progress

Volumn 103, Issue 10, 2007, Pages 40-47

  Jayapal, Karthik P ^a   Wlaschin, Katie F ^a   Hu, Wei Shou ^a   Yap, Miranda G S ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Bioprocessing Technology Institute

Author keywords

[No Author keywords available]

Indexed keywords

EID: 41849140828     PISSN: 03607275     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (45)

1. Yerganian, G., "The biology and genetics of Chinese hamster,"_Molecular Cell Genetics, John Wiley & Sons, Inc., New York, pp. 3-36 (1985).
2. Yerganian, G., "Pathology of Hamsters," Prog. Exp. Tumor Res. Res., Basel, pp. 2-41 (1972).
3. Tjio, J. H., and T. T. Puck, "Genetics of somatic mammalian cells. II. Chromosomal constitution of cells in tissue culture," J. Exp. Med., 108(2), pp. 259-268 (1958).
4. Chasin, L. A., and G. Urlaub, "Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells," Science, 187(4181), pp. 1091-1093 (1975).
5. Simon, A. E.,et al., "Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture," Mol. Cell Biol., 2(9), pp. 1126-1133 (1982).
6. Puck, T. T., "Development of the Chinese hamster ovary (CHO) cell," Molecular Cell Genetics, John Wiley & Sons, New York, pp. 37-64 (1985).
7. Puck, T. T., and F. T. Kao, "Genetics of somatic mammalian cells. V. Treatment with 5-bromodeoxyuridine and visible light for isolation of nutritionally deficient mutants," Proc. Natl. Acad. Sci. USA, 58(3), pp. 1227-1234 (1967).
8. Taylor, M. W., et al., "Purine mutants of mammalian cell lines: III. Control of purine biosynthesis in adenine phosphoribosyl transferase mutants of CHO cells," Somatic Cell Genet., 3(2), pp. 195-206 (1977).
9. Urlaub, G., and L. A. Chasin, "Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity," Proc. Natl. Acad Sci. USA, 77(7), pp. 42164220 (1980).
10. Adair, G. M., and J. H. Carver, "unstable, non-mutational expression of resistance to the thymidine analogue, trifluorothymidine in CHO cells," Mutat. Res., 60(2), pp. 207-213 (1979).
11. Chan, V. L., et al., "Mammalian cells with altered forms of RNA polymerase II," Proc. Natl. Acad. Sci. USA. 69 (11), pp. 3119-123 (1972).
12. Goldferb, P. S. et al., "The isolation and characterization of asparagine-requiring mutants of Chinese hamster cells," Exp. Cell. Res., 104(2), pp. 357-367 (1977).
13. Thompson, L. H., et al., "A mammalian cell mutant with a temperature-sensitive leucyl-transfer RNA synthetase," Proc. Natl. Acad. Sci. USA, 70(11), pp. 3094-3098 (1973).
14. Waye, M. M. and C. P. Stanners, "Isolation and characterization of CHO cell mutants with altered asparagine synthetase," Somatic Cell Genet., 5(5), pp. 625-639 (1979).
15. Figler, H., et al., "Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract Guanine nucleotide effects on agonist binding," Mol. Pharmacol., 64(6). pp. 1557-1564 (2003).
16. Hornigold, D. C., et al., "Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells," Br. J. Pharmacol., 138(7). pp. 1340-1350 (2003).
17. Schulte, G., and B. B. Fredholm, "The G(s)-coupled adenosine A(2B) receptor recruits divergent pamways to regulate ERK1/2 and p38," Exp. Cell Res., 290(1), pp. 168-176 (2003).
18. Hari, M., et al., "Mutations in alpha- and beta-tubulin that stabilize microtubules and confer resistance to colcemid and vinblastine," Mol. Cancer Ther., 2(7), pp. 597-605 (2003).
19. Zeng, Q., et al., "PRL-3 and PRL-1 promote cell migration, invasion, and metastasis," Cancer Res., 63(11), pp. 2716-2722 (2003).
20. Fiore, M., et al., "Reversible G(1) arrest by dimethyl sulfoxide as a new method to synchronize Chinese hamster cells," Mutagenesis, 17(5), pp. 419-424 (2002).
21. Batista, L. F., et al., "Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells," Apoptosis, 11(7), pp. 1139-1148(2006).
22. Dunkern, T. R., and B. Kaina, "Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells," Mol. Biol. Cell, 13(1), pp. 348-361 (2002).
23. Fernandez, M. J., et al., "Apoptosis induced by different doses of caffeine on Chinese hamster ovary cells," J. Appl. Toxicol., 23(4), pp. 221-224 (2003).
24. Soloneski, S., et al., "Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro. III. Genotoxic evaluation on Chinese hamster ovary (CHO) cells," Mutat. Res., 514(1-2), pp. 201-212 (2002).
25. Cai, Y., et al., "Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells," Mol. Cancer Then, 1(1), pp. 21-28 (2001).
26. Wurm, F. M., "The industry's workhorses-Mammalian expression systems," Modern biopharmaceuticals, Wiley-VCH, Weiheim, 3, pp. 723-759 (2005).
27. Wiebe, M. E., et al., "A mulufaceted approach to assure that recombinant tPA is free of adventitious virus," Advances in animal cell biology and technology, Butterworth-Heinemann, London, pp. 68-71 (1989).
28. Graf, L. H., Jr., and L. A. Chasin, "Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation," Mol. Cell Biol., 2(1), pp. 93-96 (1982).
29. Urlaub, G., et al., "Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells," Cell, 33(2), pp. 405-412 (1983).
30. Kao, F. T., and T. T. Puck, "Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells," Proc. Natl. Acad Sci. USA, 60(4), pp. 1275-1281 (1968).
31. Girod, P., and N. Mermod, "Use of scaffold/matrix-attachment regions for protein production," Gene transfer and expression in mammalian cells. Elsevier, Amsterdam, pp. 359-379 (2003).
32. Antoniou, M., et al., 'Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing," Genomics, 82(3), pp. 269-279 (2003).
33. Seth, G., et al., "Engineering cells for cell culture bioprocessing-physiological fundamentals," Adv. Biochem. Eng. Biotechnol., 101, pp. 119-164 (2006).
34. Irani, et al., "Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction," Biotechnol. Bioeng., 66(4), pp. 238-246 (1999).
35. Jeong, D. W., et al., "Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism," Mol. Cell Biochem., 284(1-2), pp. 1-8 (2006).
36. Wlaschin, K. F., and W. S. Hu, "Engineering cell metabolism for high-density cell culture via manipulation of sugar transport," J. Biotechnol., 131(2), pp. 168-176 (2007).
37. Mastrangelo, A. J., et al., "Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults," Biotechnol. Bioeng., 67(5), pp. 555-564 (2000).
38. Meents, H., et al., 'Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media," Biotechnol. Bioeng., 80(6), pp. 706-716 (2002).
39. Sriburi, R., et al., "XBP1 : A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum," J. Cell. Biol., 167(1), pp. 35-41 (2004).
40. Elliott, S., et al., "Enhancement of therapeutic protein in vivo activities through glycoengineering," Nat. Biotechnol., 21(4), pp. 414-421 (2003).
41. Wong, D. C. et al., 'Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures," Biotechnol. Bioeng., 94(2), pp. 373-382 (2006).
42. Van Dyk, D. D., et al., "Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line," Proteomics, 3(2), pp. 147-156 (2003).
43. Kaufmann, H., et al., "Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells," Biotechnol. Bioeng., 63(5), pp. 573-582 (1999).
44. Wlaschin, K. F., et al., "EST sequencing for gene discovery in Chinese hamster ovary cells," Biotechnol. Bioeng., 91(5), pp. 592-606 (2005).
45. Wlaschin, K. F., and W. S. Hu, "A scaffold for the Chinese hamster genome," Biotechnol. Bioeng., Epub ahead of print (2007).