Xenobiotic-sensing nuclear receptors involved in drug metabolism: A structural perspective

Drug Metabolism Reviews

Volumn 45, Issue 1, 2013, Pages 79-100

  Wallace, Bret D ^a   Redinbo, Matthew R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Agonist; Antagonism; Coactivator; Corepressor; Drug metabolism; Ligand binding domain; Nuclear receptors; Structural biology; Xenobiotics

Indexed keywords

6 CHLORO 2 [(1 FURO[2,3 C]PYRIDIN 5 YLETHYL)THIO] 4 PYRIMIDINAMINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTILIPEMIC AGENT; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; FARNESOID X RECEPTOR; GLUCOCORTICOID RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HYPERICUM PERFORATUM EXTRACT; LIVER X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID X RECEPTOR; RIFAMPICIN; SR 12813; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

BIOSENSOR; CRYSTAL STRUCTURE; DRUG METABOLISM; DRUG TRANSFORMATION; GENE CONTROL; HUMAN; IN VIVO STUDY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; TISSUE DISTRIBUTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; GENE EXPRESSION; HUMANS; LIGANDS; METABOLIC DETOXICATION, DRUG; MODELS, MOLECULAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; XENOBIOTICS;

EID: 84872699692     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2012.740049     Document Type: Review

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