SCOPUS 정보 검색 플랫폼

Science

Volumn 286, Issue 5439, 1999, Pages 487-491

Pharmacogenomics: Translating functional genomics into rational therapeutics

(2) Evans, William E a Relling, Mary V a

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE DERIVATIVE; ANTIDEPRESSANT AGENT; AZATHIOPRINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAPTOPRIL; CISAPRIDE; CLARITHROMYCIN; CODEINE; DEBRISOQUINE; DEXTROMETHORPHAN; ENALAPRIL; ENCAINIDE; FLECAINIDE; FLUOROURACIL; LISINOPRIL; MERCAPTOPURINE; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PERHEXILINE; PHENACETIN; PHENFORMIN; PHENYTOIN; PROPAFENONE; PROPYLAMINE; QUINIDINE; SPARTEINE; TIOGUANINE; TOLBUTAMIDE; UNINDEXED DRUG; WARFARIN;

DNA POLYMORPHISM; DRUG DISPOSITION; DRUG METABOLISM; DRUG TARGETING; DRUG TRANSPORT; GENOTYPE; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW;

CARRIER PROTEINS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG THERAPY; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOGENETICS; PHARMACOKINETICS; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, DRUG;

EID: 0033569516 PISSN: 00368075 EISSN: None Source Type: Journal
DOI: 10.1126/science.286.5439.487 Document Type: Review

Times cited : (2197)

References (73)

1
- 49749154208
- W. Kalow, Lancet 211, 576 (1956).
- (1956) Lancet , vol.211 , pp. 576
- Kalow, W.¹

2
- 0000616920
- P. E. Carson, C. L. Flanagan, C. E. Ickes, A. S. Alving, Science 124, 484 (1956).
- (1956) Science , vol.124 , pp. 484
- Carson, P.E.¹ Flanagan, C.L.² Ickes, C.E.³ Alving, A.S.⁴

3
- 0006948626
- H. B. Hughes, J. P. Biehl, A. P. Jones, L H. Schmidt, Am. Rev. Tuberc. 70, 266 (1954); D. A. P. Evans, K. A. Manley, V. A. McKusick, Br. Med. J. 2, 485 (1960).
- (1954) Am. Rev. Tuberc. , vol.70 , pp. 266
- Hughes, H.B.¹ Biehl, J.P.² Jones, A.P.³ Schmidt, L.H.⁴

4
- 26444539817
- H. B. Hughes, J. P. Biehl, A. P. Jones, L H. Schmidt, Am. Rev. Tuberc. 70, 266 (1954); D. A. P. Evans, K. A. Manley, V. A. McKusick, Br. Med. J. 2, 485 (1960).
- (1960) Br. Med. J. , vol.2 , pp. 485
- Evans, D.A.P.¹ Manley, K.A.² McKusick, V.A.³

5
- 0031035007
- D. W. Nebert, Am. J. Hum. Genet 60, 265 (1997); U. A. Meyer and U. M. Zanger, Annu. Rev. Pharmacol. Toxicol. 37, 269 (1997).
- (1997) Am. J. Hum. Genet , vol.60 , pp. 265
- Nebert, D.W.¹

6
- 0030995879
- D. W. Nebert, Am. J. Hum. Genet 60, 265 (1997); U. A. Meyer and U. M. Zanger, Annu. Rev. Pharmacol. Toxicol. 37, 269 (1997).
- (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269
- Meyer, U.A.¹ Zanger, U.M.²

7
- 0023854270
- F. J. Gonzalez et al., Nature 331, 442 (1988).
- (1988) Nature , vol.331 , pp. 442
- Gonzalez, F.J.¹

8
- 0032231751
- E. Y. Krynetski and W. E. Evans, Am. J. Hum. Genet. 63, 11 (1998).
- (1998) Am. J. Hum. Genet. , vol.63 , pp. 11
- Krynetski, E.Y.¹ Evans, W.E.²

9
- 0025868355
- J. Desmeules, M. P. Gascon, P. Dayer, M. Magistris, Eur. J. Clin. Pharmacol. 41, 23 (1991); L. Poulsen et al., ibid. 51, 289 (1996).
- (1991) Eur. J. Clin. Pharmacol. , vol.41 , pp. 23
- Desmeules, J.¹ Gascon, M.P.² Dayer, P.³ Magistris, M.⁴

10
- 0030472254
- J. Desmeules, M. P. Gascon, P. Dayer, M. Magistris, Eur. J. Clin. Pharmacol. 41, 23 (1991); L. Poulsen et al., ibid. 51, 289 (1996).
- (1996) Eur. J. Clin. Pharmacol. , vol.51 , pp. 289
- Poulsen, L.¹

11
- 0017695082
- A. Mahgoub, J. R. Idle, L. G. Dring, R. Lancaster, R. L. Smith, Lancet 2, 584 (1977).
- (1977) Lancet , vol.2 , pp. 584
- Mahgoub, A.¹ Idle, J.R.² Dring, L.G.³ Lancaster, R.⁴ Smith, R.L.⁵

12
- 0031011356
- D. M. Grant et al., Mutat. Res. 376, 61 (1997); S. P. Spielberg, J. Pharmacokinet. Biopharm. 24, 509 (1996).
- (1997) Mutat. Res. , vol.376 , pp. 61
- Grant, D.M.¹

13
- 0030426571
- D. M. Grant et al., Mutat. Res. 376, 61 (1997); S. P. Spielberg, J. Pharmacokinet. Biopharm. 24, 509 (1996).
- (1996) J. Pharmacokinet. Biopharm. , vol.24 , pp. 509
- Spielberg, S.P.¹

14
- 0029045650
- H. Nakamura et al., J. Pharmacol. Exp. Ther. 274, 1099 (1995); M. Blum, A. Demierre, D. M. Grant, M. Heim, U. A. Meyer, Proc. Natl. Acad. Sci. U.S.A. 88, 5237 (1991).
- (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1099
- Nakamura, H.¹

15
- 0025948280
- H. Nakamura et al., J. Pharmacol. Exp. Ther. 274, 1099 (1995); M. Blum, A. Demierre, D. M. Grant, M. Heim, U. A. Meyer, Proc. Natl. Acad. Sci. U.S.A. 88, 5237 (1991).
- (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 5237
- Blum, M.¹ Demierre, A.² Grant, D.M.³ Heim, M.⁴ Meyer, U.A.⁵

16
- 0029919926
- M. J. Ratain et al., Pharmacogenetics 6, 93 (1996).
- (1996) Pharmacogenetics , vol.6 , pp. 93
- Ratain, M.J.¹

17
- 0027319640
- S. H. Sindrup, L. Poulsen, K. Brosen, L. Arendt-Nielsen, L. F. Gram, Pain 53, 335 (1993).
- (1993) Pain , vol.53 , pp. 335
- Sindrup, S.H.¹ Poulsen, L.² Brosen, K.³ Arendt-Nielsen, L.⁴ Gram, L.F.⁵

18
- 0023902287
- R. B. Diasio, T. L. Beavers, J. T. Carpenter, J. Clin. Invest. 81, 47 (1988); F. J. Gonzalez and P. Fernandez-Salguero, Trends. Pharmacol. Sci. 16, 325 (1995).
- (1988) J. Clin. Invest. , vol.81 , pp. 47
- Diasio, R.B.¹ Beavers, T.L.² Carpenter, J.T.³

19
- 0029133354
- R. B. Diasio, T. L. Beavers, J. T. Carpenter, J. Clin. Invest. 81, 47 (1988); F. J. Gonzalez and P. Fernandez-Salguero, Trends. Pharmacol. Sci. 16, 325 (1995).
- (1995) Trends. Pharmacol. Sci. , vol.16 , pp. 325
- Gonzalez, F.J.¹ Fernandez-Salguero, P.²

20
- 0032547341
- T. R. Rebbeck, J. M. Jaffe, A. H. Walker, A. J. Wein, S. B. Malkowicz, J. Natl. Cancer Inst. 90, 1225 (1998); C. A. Felix et al., Proc. Natl. Acad. Sci. U.S.A. 95, 13176 (1998).
- (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1225
- Rebbeck, T.R.¹ Jaffe, J.M.² Walker, A.H.³ Wein, A.J.⁴ Malkowicz, S.B.⁵

21
- 13144282667
- T. R. Rebbeck, J. M. Jaffe, A. H. Walker, A. J. Wein, S. B. Malkowicz, J. Natl. Cancer Inst. 90, 1225 (1998); C. A. Felix et al., Proc. Natl. Acad. Sci. U.S.A. 95, 13176 (1998).
- (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13176
- Felix, C.A.¹

22
- 0032601755
- E. G. Schuetz and A. H. Schinkel, J. Biochem. Mol. Toxicol. 13, 219 (1999); E. G. Schuetz, W. T. Beck J. D. Schuetz, Mol. Pharmacol. 49, 311 (1996); V. J. Wacher, C. Y. Wu, L. Z. Benet, Mol. Carcinog. 13, 129 (1995).
- (1999) J. Biochem. Mol. Toxicol. , vol.13 , pp. 219
- Schuetz, E.G.¹ Schinkel, A.H.²

23
- 0030059953
- E. G. Schuetz and A. H. Schinkel, J. Biochem. Mol. Toxicol. 13, 219 (1999); E. G. Schuetz, W. T. Beck J. D. Schuetz, Mol. Pharmacol. 49, 311 (1996); V. J. Wacher, C. Y. Wu, L. Z. Benet, Mol. Carcinog. 13, 129 (1995).
- (1996) Mol. Pharmacol. , vol.49 , pp. 311
- Schuetz, E.G.¹ Beck, W.T.² Schuetz, J.D.³

24
- 0029028792
- E. G. Schuetz and A. H. Schinkel, J. Biochem. Mol. Toxicol. 13, 219 (1999); E. G. Schuetz, W. T. Beck J. D. Schuetz, Mol. Pharmacol. 49, 311 (1996); V. J. Wacher, C. Y. Wu, L. Z. Benet, Mol. Carcinog. 13, 129 (1995).
- (1995) Mol. Carcinog. , vol.13 , pp. 129
- Wacher, V.J.¹ Wu, C.Y.² Benet, L.Z.³

25
- 0031158805
- A. H. Schinkel, Semin. Cancer Biol. 8, 161 (1997); L. A. Mickley et al., Blood 91, 1749 (1998); N. Kioka et al., Biochem. Biophys. Res. Commun. 162, 224 (1989).
- (1997) Semin. Cancer Biol. , vol.8 , pp. 161
- Schinkel, A.H.¹

26
- 0032030654
- A. H. Schinkel, Semin. Cancer Biol. 8, 161 (1997); L. A. Mickley et al., Blood 91, 1749 (1998); N. Kioka et al., Biochem. Biophys. Res. Commun. 162, 224 (1989).
- (1998) Blood , vol.91 , pp. 1749
- Mickley, L.A.¹

27
- 0024362996
- A. H. Schinkel, Semin. Cancer Biol. 8, 161 (1997); L. A. Mickley et al., Blood 91, 1749 (1998); N. Kioka et al., Biochem. Biophys. Res. Commun. 162, 224 (1989).
- (1989) Biochem. Biophys. Res. Commun. , vol.162 , pp. 224
- Kioka, N.¹

28
- 0031466866
- F. D. Martinez et al., J. Clin. Invest. 100, 3184 (1997); R. J. Hancox, M. R. Sears, D. R. Taylor, Eur. Respir. J. 11, 589 (1999); B. J. Lipworth, I. P. Hall, S. Tan, I. Aziz, J. C. Crabbe, Chest 115, 324 (1999); J. J. Lima et al., Clin. Pharmacol. Ther. 65, 519 (1999).
- (1997) J. Clin. Invest. , vol.100 , pp. 3184
- Martinez, F.D.¹

29
- 0031597001
- F. D. Martinez et al., J. Clin. Invest. 100, 3184 (1997); R. J. Hancox, M. R. Sears, D. R. Taylor, Eur. Respir. J. 11, 589 (1999); B. J. Lipworth, I. P. Hall, S. Tan, I. Aziz, J. C. Crabbe, Chest 115, 324 (1999); J. J. Lima et al., Clin. Pharmacol. Ther. 65, 519 (1999).
- (1999) Eur. Respir. J. , vol.11 , pp. 589
- Hancox, R.J.¹ Sears, M.R.² Taylor, D.R.³

30
- 0032909902
- F. D. Martinez et al., J. Clin. Invest. 100, 3184 (1997); R. J. Hancox, M. R. Sears, D. R. Taylor, Eur. Respir. J. 11, 589 (1999); B. J. Lipworth, I. P. Hall, S. Tan, I. Aziz, J. C. Crabbe, Chest 115, 324 (1999); J. J. Lima et al., Clin. Pharmacol. Ther. 65, 519 (1999).
- (1999) Chest , vol.115 , pp. 324
- Lipworth, B.J.¹ Hall, I.P.² Tan, S.³ Aziz, I.⁴ Crabbe, J.C.⁵

31
- 0345501553
- F. D. Martinez et al., J. Clin. Invest. 100, 3184 (1997); R. J. Hancox, M. R. Sears, D. R. Taylor, Eur. Respir. J. 11, 589 (1999); B. J. Lipworth, I. P. Hall, S. Tan, I. Aziz, J. C. Crabbe, Chest 115, 324 (1999); J. J. Lima et al., Clin. Pharmacol. Ther. 65, 519 (1999).
- (1999) Clin. Pharmacol. Ther. , vol.65 , pp. 519
- Lima, J.J.¹

32
- 0030837677
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1997) Nephrol. Dial. Transplant. , vol.12 , Issue.2 SUPPL. , pp. 42
- Van Der Kleij, F.G.¹

33
- 7144223417
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1998) Kidney Blood Press. Res. , vol.21 , pp. 66
- Haas, M.¹

34
- 0031297768
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1997) Kidney Int. Suppl. , vol.63
- Van Der Kleij, F.G.¹

35
- 0030859402
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1997) Am. J. Hypertens. , vol.10 , pp. 1064
- Nakano, Y.¹

36
- 0031673596
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1998) J. Cardiovasc. Pharmacol. , vol.32 , pp. 988
- O'Toole, L.¹ Stewart, M.² Padfield, P.³ Channer, K.⁴

37
- 0030474233
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1996) J. Hypertens. , vol.14 , pp. 1403
- Sasaki, M.¹

38
- 0031053270
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1997) Nephron , vol.75 , pp. 310
- Mizuiri, S.¹

39
- 0028848097
- F. G. van der Kleij et al., Nephrol. Dial. Transplant. 12 (suppl. 2), 42 (1997); M. Haas et al. Kidney Blood Press. Res. 21, 66 (1998); F. G. van der Kleij et al., Kidney Int. Suppl. 63, S23 (1997); Y. Nakano et al., Am. J. Hypertens. 10, 1064 (1997); L O'Toole, M. Stewart, P. Padfield, K. Channer, J. Cardiovasc. Pharmacol. 32, 988 (1998); M. Sasaki et al., J. Hypertens. 14, 1403 (1996); S. Mizuiri et al., Nephron 75, 310 (1997); H. Yoshida et at., J. Clin. Invest. 96, 2162 (1995).
- (1995) J. Clin. Invest. , vol.96 , pp. 2162
- Yoshida, H.¹

40
- 7844248657
- D. Henrion et al., J. Vasc. Res. 35, 356 (1998).
- (1998) J. Vasc. Res. , vol.35 , pp. 356
- Henrion, D.¹

41
- 10544228945
- A. Benetos et al., Hypertension 28, 1081 (1996).
- (1996) Hypertension , vol.28 , pp. 1081
- Benetos, A.¹

42
- 0030066519
- G. G. V. Essen et al., Lancet 347, 94 (1996).
- (1996) Lancet , vol.347 , pp. 94
- Essen, G.G.V.¹

43
- 0029100429
- M. Arranz et al., ibid. 346, 281 (1995).
- (1995) Lancet , vol.346 , pp. 281
- Arranz, M.¹

44
- 0007691164
- J. Poirier, Proc. Natl. Acad. Sci. U.S.A. 92, 12260 (1995).
- (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 12260
- Poirier, J.¹

45
- 0032495541
- J. A. Kuivenhoven, N. Engl. J. Med. 338, 86 (1998).
- (1998) N. Engl. J. Med. , vol.338 , pp. 86
- Kuivenhoven, J.A.¹

46
- 0030903368
- V. M. Steen, R. Loviie, T. MacEwan, R. G. McCreadie, Mol. Psychiatry 2, 139 (1997); C. H. Chen, F. C. Wei, F. J. Koong, K. J. Hsiao, Biol. Psychiatry 41, 827 (1997).
- (1997) Mol. Psychiatry , vol.2 , pp. 139
- Steen, V.M.¹ Loviie, R.² MacEwan, T.³ McCreadie, R.G.⁴

47
- 0030975438
- V. M. Steen, R. Loviie, T. MacEwan, R. G. McCreadie, Mol. Psychiatry 2, 139 (1997); C. H. Chen, F. C. Wei, F. J. Koong, K. J. Hsiao, Biol. Psychiatry 41, 827 (1997).
- (1997) Biol. Psychiatry , vol.41 , pp. 827
- Chen, C.H.¹ Wei, F.C.² Koong, F.J.³ Hsiao, K.J.⁴

48
- 0033574273
- G. W. Abbott et al., Cell 97, 175 (1999).
- (1999) Cell , vol.97 , pp. 175
- Abbott, G.W.¹

49
- 0026662792
- E. F. Gillard et al., Genomics 13, 1247 (1992).
- (1992) Genomics , vol.13 , pp. 1247
- Gillard, E.F.¹

50
- 0031019954
- J. Cohen, Science 275, 776 (1997); A. Marshall, Nature Biotechnol. 15, 954 (1997).
- (1997) Science , vol.275 , pp. 776
- Cohen, J.¹

51
- 0030770412
- J. Cohen, Science 275, 776 (1997); A. Marshall, Nature Biotechnol. 15, 954 (1997).
- (1997) Nature Biotechnol. , vol.15 , pp. 954
- Marshall, A.¹

52
- 0033168459
- F. S. Collins, N. Engl. J. Med. 341, 28 (1999); P. W. Kleyn and E. S. Vesell, Science 281, 1820 (1998).
- (1999) N. Engl. J. Med. , vol.341 , pp. 28
- Collins, F.S.¹

53
- 0032544336
- F. S. Collins, N. Engl. J. Med. 341, 28 (1999); P. W. Kleyn and E. S. Vesell, Science 281, 1820 (1998).
- (1998) Science , vol.281 , pp. 1820
- Kleyn, P.W.¹ Vesell, E.S.²

54
- 0032545976
- W. E. Evans et al., N. Engl. J. Med. 338, 499 (1998).
- (1998) N. Engl. J. Med. , vol.338 , pp. 499
- Evans, W.E.¹

55
- 0032572912
- C. H. Pui and W. E. Evans, ibid 339, 605 (1998).
- (1998) N. Engl. J. Med. , vol.339 , pp. 605
- Pui, C.H.¹ Evans, W.E.²

56
- 0033608466
- G. P. Aithal, C. P. Day, P. J. Kesteven, A. K. Daly, Lancet 353, 717 (1999); D. J. Steward et al., Pharmacogenetics 7, 361 (1997).
- (1999) Lancet , vol.353 , pp. 717
- Aithal, G.P.¹ Day, C.P.² Kesteven, P.J.³ Daly, A.K.⁴

57
- 0030868485
- G. P. Aithal, C. P. Day, P. J. Kesteven, A. K. Daly, Lancet 353, 717 (1999); D. J. Steward et al., Pharmacogenetics 7, 361 (1997).
- (1997) Pharmacogenetics , vol.7 , pp. 361
- Steward, D.J.¹

58
- 0032572604
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1998) Schlzophr. Res. , vol.32 , pp. 101
- Kapitany, T.¹

59
- 0030432381
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 1165
- Caraco, Y.¹ Sheller, J.² Wood, A.J.³

60
- 0030765119
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1997) Pharmacogenetics , vol.7 , pp. 375
- Tyndale, R.F.¹ Droll, K.P.² Sellers, E.M.³

61
- 0024359574
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1989) Eur. J. Clin. Pharmacol. , vol.36 , pp. 537
- Brosen, K.¹

62
- 0024959582
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1989) W. Engl. J. Med. , vol.320 , pp. 565
- Zhou, H.H.¹ Koshakji, R.P.² Silberstein, D.J.³ Wilkinson, G.R.⁴ Wood, A.J.⁵

63
- 0021082394
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1983) Clin. Pharmacol. Ther. , vol.34 , pp. 732
- Lennard, M.S.¹

64
- 0025312448
- T. Kapitany et al., Schlzophr. Res. 32, 101 (1998); Y. Caraco, J. Sheller, A. J. Wood, J. Pharmacol. Exp. Ther. 278, 1165 (1996); R. F. Tyndale, K. P. Droll, E. M. Sellers, Pharmacogenetics 7, 375 (1997); K. Brosen, Eur. J. Clin. Pharmacol. 36, 537 (1989); H. H. Zhou, R. P. Koshakji, D. J. Silberstein, G. R. Wilkinson, A. J. Wood, W. Engl. J. Med. 320, 565 (1989); M. S. Lennard et al., Clin. Pharmacol. Ther. 34, 732 (1983); J. T. Lee et al., N. Engl. J. Med. 322, 1764 (1990).
- (1990) N. Engl. J. Med. , vol.322 , pp. 1764
- Lee, J.T.¹

65
- 0033135738
- M. V. Relling, M. L. Hancock, J. M. Boyett, C.-H. Pui, W. E. Evans, Blood 93, 2817 (1999); M. V. Relling et al., Lancet 354, 34 (1999); A. J. Black et al., Ann. Intern. Med. 129, 716 (1993); L. Lennard, Ther. Drug Monit. 20, 527 (1998); J. Aarbakke, G. Janka-Schaub, G. B. Elion, Trends. Pharmacol. Sci. 18, 3 (1997); L. Lennard, J. A. Van Loon, J. S. Lilleyman, R. M. Weinshilboum, Clin. Pharmacol. Ther. 41, 18 (1987).
- (1999) Blood , vol.93 , pp. 2817
- Relling, M.V.¹ Hancock, M.L.² Boyett, J.M.³ Pui, C.-H.⁴ Evans, W.E.⁵

66
- 0033519986
- M. V. Relling, M. L. Hancock, J. M. Boyett, C.-H. Pui, W. E. Evans, Blood 93, 2817 (1999); M. V. Relling et al., Lancet 354, 34 (1999); A. J. Black et al., Ann. Intern. Med. 129, 716 (1993); L. Lennard, Ther. Drug Monit. 20, 527 (1998); J. Aarbakke, G. Janka-Schaub, G. B. Elion, Trends. Pharmacol. Sci. 18, 3 (1997); L. Lennard, J. A. Van Loon, J. S. Lilleyman, R. M. Weinshilboum, Clin. Pharmacol. Ther. 41, 18 (1987).
- (1999) Lancet , vol.354 , pp. 34
- Relling, M.V.¹

67
- 0032212759
- M. V. Relling, M. L. Hancock, J. M. Boyett, C.-H. Pui, W. E. Evans, Blood 93, 2817 (1999); M. V. Relling et al., Lancet 354, 34 (1999); A. J. Black et al., Ann. Intern. Med. 129, 716 (1993); L. Lennard, Ther. Drug Monit. 20, 527 (1998); J. Aarbakke, G. Janka-Schaub, G. B. Elion, Trends. Pharmacol. Sci. 18, 3 (1997); L. Lennard, J. A. Van Loon, J. S. Lilleyman, R. M. Weinshilboum, Clin. Pharmacol. Ther. 41, 18 (1987).
- (1993) Ann. Intern. Med. , vol.129 , pp. 716
- Black, A.J.¹

68
- 0031663491
- M. V. Relling, M. L. Hancock, J. M. Boyett, C.-H. Pui, W. E. Evans, Blood 93, 2817 (1999); M. V. Relling et al., Lancet 354, 34 (1999); A. J. Black et al., Ann. Intern. Med. 129, 716 (1993); L. Lennard, Ther. Drug Monit. 20, 527 (1998); J. Aarbakke, G. Janka-Schaub, G. B. Elion, Trends. Pharmacol. Sci. 18, 3 (1997); L. Lennard, J. A. Van Loon, J. S. Lilleyman, R. M. Weinshilboum, Clin. Pharmacol. Ther. 41, 18 (1987).
- (1998) Ther. Drug Monit. , vol.20 , pp. 527
- Lennard, L.¹

69
- 0031036786
- M. V. Relling, M. L. Hancock, J. M. Boyett, C.-H. Pui, W. E. Evans, Blood 93, 2817 (1999); M. V. Relling et al., Lancet 354, 34 (1999); A. J. Black et al., Ann. Intern. Med. 129, 716 (1993); L. Lennard, Ther. Drug Monit. 20, 527 (1998); J. Aarbakke, G. Janka-Schaub, G. B. Elion, Trends. Pharmacol. Sci. 18, 3 (1997); L. Lennard, J. A. Van Loon, J. S. Lilleyman, R. M. Weinshilboum, Clin. Pharmacol. Ther. 41, 18 (1987).
- (1997) Trends. Pharmacol. Sci. , vol.18 , pp. 3
- Aarbakke, J.¹ Janka-Schaub, G.² Elion, G.B.³

70
- 0023119219
- M. V. Relling, M. L. Hancock, J. M. Boyett, C.-H. Pui, W. E. Evans, Blood 93, 2817 (1999); M. V. Relling et al., Lancet 354, 34 (1999); A. J. Black et al., Ann. Intern. Med. 129, 716 (1993); L. Lennard, Ther. Drug Monit. 20, 527 (1998); J. Aarbakke, G. Janka-Schaub, G. B. Elion, Trends. Pharmacol. Sci. 18, 3 (1997); L. Lennard, J. A. Van Loon, J. S. Lilleyman, R. M. Weinshilboum, Clin. Pharmacol. Ther. 41, 18 (1987).
- (1987) Clin. Pharmacol. Ther. , vol.41 , pp. 18
- Lennard, L.¹ Van Loon, J.A.² Lilleyman, J.S.³ Weinshilboum, R.M.⁴

71
- 0033537474
- S. G. Priori et al., Circulation 99, 674 (1999); C. Donger et al., ibid. 96, 2778 (1997).
- (1999) Circulation , vol.99 , pp. 674
- Priori, S.G.¹

72
- 19244371485
- S. G. Priori et al., Circulation 99, 674 (1999); C. Donger et al., ibid. 96, 2778 (1997).
- (1997) Circulation , vol.96 , pp. 2778
- Donger, C.¹

73
- 0345069947
- note
- Supported in part by grants NIH R37 CA36401, RO1 CA51001, and RO1 CA78224; Cancer Center support grant CA21765; a Center of Excellence grant from the state of Tennessee; and the American Lebanese Syrian Associated Charities (ALSAC). We thank J. Johnson, M. Kastan, C. Naeve, D. Roden, E. Schuetz, J. Schuetz, and E. Tuomanen for helpful suggestions; L. Rawlinson for artistic contributions to Figs. 1 and 3; and S. Davis, G. McDugle, and F. Munn for help in preparing the manuscript.

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