PPARα agonists up-regulate organic cation transporters in rat liver cells

Biochemical and Biophysical Research Communications

Volumn 350, Issue 3, 2006, Pages 704-708

  Luci, Sebastian ^a   Geissler, Stefanie ^a   König, Bettina ^a   Koch, Alexander ^a   Stangl, Gabriele I ^a   Hirche, Frank ^a   Eder, Klaus ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Carnitine; Organic cation transporter; Peroxisome proliferator activated receptor ; Rat

Indexed keywords

CARNITINE; CLOFIBRATE; MESSENGER RNA; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PIRINIXIC ACID; CATECHOLAMINE TRANSPORTER; ORGANIC CATION TRANSPORTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SLC22A1 PROTEIN, RAT; SLC22A2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); DRUG EFFECT; HEPATOMA CELL; LIVER CARCINOGENESIS; LIVER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT; RNA ANALYSIS; UPREGULATION; ANIMAL; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; LIVER CELL CARCINOMA; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CATECHOLAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; CELLS, CULTURED; CLOFIBRATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; MALE; ORGANIC CATION TRANSPORT PROTEINS; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 33749648743     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.09.099     Document Type: Article

References (26)

1. McGarry J.D., and Brown N.F. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244 (1997) 1-14
2. Brass E.P. Pivalate-generating prodrugs and carnitine homeostasis in man. Pharmacol. Rev. 54 (2002) 589-598
3. Steiber A., Kerner J., and Hoppel C.L. Carnitine: a nutritional, biosynthetic, and functional perspective. Mol. Aspects Med. 25 (2004) 455-473
4. Rebouche C.J., and Seim H. Carnitine metabolism and its regulation in microorganisms and mammals. Annu. Rev. Nutr. 18 (1998) 39-61
5. Hoppel C.L., and Davis A.T. Inter-tissue relationships in the synthesis and distribution of carnitine. Biochem. Soc. Trans. 14 (1986) 673-674
6. Vaz F.M., and Wanders R.J. Carnitine biosynthesis in mammals. Biochem. J. 361 (2002) 417-429
7. Evans A.M., and Fornasini G. Pharmacokinetics of l-carnitine. Clin. Pharmacokinet. 42 (2003) 941-967
8. Tein I. Carnitine transport: pathophysiology and metabolism of known defects. J. Inherit. Metab. Dis. 26 (2003) 147-169
9. Paul H.S., and Adibi S.A. Paradoxical effects of clofibrate on liver and muscle metabolism in rats. Induction of myotonia and alteration of fatty acid and glucose oxidation. J. Clin. Invest. 64 (1979) 405-412
10. Paul H.S., Gleditsch C.E., and Adibi S.A. Mechanism of increased hepatic concentration of carnitine by clofibrate. Am. J. Physiol. 251 (1986) E311-E315
11. Schoonjans K., Peinado-Onsurbe J., Lefebvre A.M., Heyman R.A., Briggs M., Deeb S., Staels B., and Auwerx J. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15 (1996) 5336-5348
12. Kramer J.A., Blomme E.A., Bunch R.T., Davila J.C., Jackson C.J., Jones P.F., Kolaja K.L., and Curtiss S.W. Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate. Toxicol. Pathol. 31 (2003) 417-431
13. Mandard S., Müller M., and Kersten S. Peroxisome proliferator receptor α target genes. Cell Mol. Life Sci. 61 (2004) 393-416
14. Slitt A.L., Cherrington N.J., Hartley D.P., Leazer M.T., and Klaassen C.D. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab. Dispos. 30 (2002) 212-219
15. McGarry J.D., Robles-Valdes C., and Foster D.W. Role of carnitine in hepatic ketogenesis. Proc. Natl. Acad. Sci. USA 72 (1975) 4385-4388
16. Brass E.P., and Hoppel C.L. Carnitine metabolism in the fasting rat. J. Biol. Chem. 253 (1978) 2688-2693
17. Kersten S., Seydoux J., Peters J.M., Gonzalez F.J., Desvergne B., and Wahli W. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103 (1999) 1489-1498
18. Mossman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
19. Vernez L., Wenk M., and Krähenbühl S. Determination of carnitine and acylcarnitines in plasma by high-performance liquid chromatography/electrospray ionization ion trap tandem mass spectrometry. Rapid Commun. Mass Spectrom. 18 (2004) 1233-1238
20. König B., and Eder K. Differential action of 13-HPODE on PPARα downstream genes in rat Fao and human HepG2 hepatoma cell lines. J. Nutr. Biochem. 17 (2006) 410-418
21. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (2001) e45
22. Brandt J.M., Djouadi F., and Kelly D. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 273 (1998) 23786-23792
23. Hashimoto T., Fujita T., Usuda N., Cook W., Qi C., Peters J.M., Gonzalez F.J., Yeldandi A.V., Rao M.S., and Reddy J.K. Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. J. Biol. Chem. 274 (1999) 19228-19236
24. Mascaro C., Acosta E., Ortiz J.A., Marrero P.F., Hegardt F.G., and Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J. Biol. Chem. 273 (1998) 8560-8563
25. Nakajima H., Kodo N., Inoue F., Kizaki Z., Nukina S., Kinugasa A., and Sawada T. Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. J. Nutr. 126 (1996) 1683-1687
26. Cheon Y., Nara T.Y., Band M.R., Beever J.E., Wallig M.A., and Nakamura M.T. Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species. Am. J. Physiol. Integr. Comp. Physiol. 288 (2005) R1525-R1535