Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

Journal of Biological Chemistry

Volumn 272, Issue 6, 1997, Pages 3137-3140

  Lehmann, Jürgen M ^a   Kliewer, Steven A ^a   Moore, Linda B ^a   Smith Oliver, Tracey A ^a   Oliver, Beverly B ^a   Su, Jui Lan ^a   Sundseth, Scott S ^a   Winegar, Deborah A ^a   Blanchard, Daniel E ^b   Spencer, Thomas A ^b   Willson, Timothy M ^a  

^a GLAXOSMITHKLINE   (United States)

^b Dartmouth College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; STEROL;

ANIMAL CELL; ARTICLE; BINDING SITE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; DNA BINDING; GENE REPRESSION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; BINDING SITES; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYCHOLESTEROLS; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

ANIMALIA;

EID: 14444285707     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.6.3137     Document Type: Article

References (32)

1. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
2. Lund, E., and Björkhem, I. (1995) Acc. Chem. Res. 28, 241-249
3. Kandutsch, A. A., Chen, H. W., and Heiniger, H.-J. (1978) Science 201, 498-501
4. Myant, N. B., and Mitropoulos, K. A. (1977) J. Lipid Res. 18, 135-153
5. Jelinek, D. E., Andersson, S., Slaughter, C. A., and Russell, D. W. (1990) J. Biol. Chem. 265, 8190-8197
6. Li, Y. C., Wang, D. P., and Chiang, J. Y. L. (1990) J. Biol. Chem. 265, 12012-12019
7. Ramirez, M. I., Karaoglu, D., Haro, D., Barillas, C., Bashirzadeh, R., and Gil, G. (1994) Mol. Cell. Biol. 14, 2809-2821
8. Pandak, W. M., Li, Y. C., Chiang, J. Y. L., Studer, E. J., Gurley, E. C., Heuman, D. M., Vlahcevic, Z. R., and Hylemon, P. B. (1991) J. Biol. Chem. 266, 3416-3421
9. Russel, D. W., and Setchell, K. D. R. (1992) Biochemistry 31, 4737-4749
10. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) Cell 83, 835-839
11. Apfel, R., Benbrook, D., Lernhardt, E., Ortiz, M. A., Salbert, G., and Pfahl, M. (1994) Mol. Cell. Biol. 14, 7025-7035
12. Willy, P. J., Umesono, K., Ong, E. S., Evans, R. M., Heyman, R. A., and Mangelsdorf, D. J. (1995) Genes & Dev. 9, 1033-1045
13. Song, C., Kokontis, J. M., Hiipakka, R. A., and Liao, S. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 10809-10813
14. Teboul, M., Enmark, E., Li, Q., Wikström, A. C., Pelto-Huikko, M., and Gustafsson, J.-A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2096-2100
15. Hoekman, M. F. M., Rientjes, J. M. J., Twisk, J., Planta, R. J., Princen, H. M. G., and Mager, W. H. (1993) Gene (Amst.) 130, 217-223
16. Chiang, J. Y. L., and Stroup, D. (1994) J. Biol. Chem. 269, 17502-17507
17. Umesono, K., Murakami, K. K., Thompson, C. C., and Evans, R. M. (1991) Cell 65, 1255-1266
18. Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995 J. Biol. Chem. 270, 12953-12956
19. Janowski, B. A., Willy, P. J., Rama Devi, T., Falck, J. R., and Mangelsdorf, D. J. (1996) Nature 383, 728-731
20. Nelson, J. A., Steckbeck, S. R., and Spencer, T. A. (1981.) J. Biol. Chem. 256, 1067-1068
21. Saucier, S. E., Kandutsch, A. A., Taylaor, F. R., Spencer, T. A., Phirwa, S., and Gayen, A. K. (1985) J. Biol. Chem. 260, 14571-14579
22. Spencer, T. A., Gayen, A. K., Phirwa, S., Nelson, J. A., Taylor, F. R., Kandutsch, A. A., and Erickson, S. K. (1985) J. Biol. Chem. 260, 13391-13394
23. Spencer, T. A. (1994) Acc. Chem. Res. 27, 83-90
24. Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Siden, A., Diczfalusy, U., and Björkhem, I. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9799-9804
25. Smith, L. L., and Johnson, B. H. (1989) Free Radical Biol. & Med. 7, 285-332
26. Kainu, T., Kononen, J., Enmark, E., Gustafsson, J. A., and Peltohuikko, M. (1996) J. Mol. Neurosci. 7, 29-39
27. Thummel, C. S. (1995) Cell 83, 871-877
28. Taylor, F. R., Kandutsch, A. A., Gayen, A. K., Nelson, J. A., Steckbeck Nelson, S., Phirwa, S., and Spencer, T. A. (1986) J. Biol. Chem. 261, 15039-15044
29. Luckow, B., and Schütz, G. (1987) Nuclei Acids Res. 15, 5490
30. Husmann, M., Lehmann, J., Hoffmann, B., Hermann, T., Tzukerman, M., and Pfahl, M. (1991) Mol. Cell. Biol. 11, 4097-4103
31. Gorski, K., Carneiro, M., and Schiebler, U. (1986) Cell 47, 767-776
32. Su, J.-L., Becherer, J. D., Edwards, C., Bukhart, W., McGeehan, G. M., and Champion, B. R. (1995) Hybridoma 14, 383-390