Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes

Biochemical and Biophysical Research Communications

Volumn 338, Issue 1, 2005, Pages 311-317

  Fujii Kuriyama, Y ^a   Mimura, J ^a  

^a NONE

Author keywords

Aryl hydrocarbon receptor; Coactivator; Cytochrome P450; Gene regulation; Transcription factor

Indexed keywords

2 (1' H INDOLE 3' CARBONYL)THIAZOLE 4 CARBOXYLIC ACID METHYL ESTER; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLORODIBENZOFURAN; 3 METHYLCHOLANTHRENE; 6 FORMYLINDOLO[3,2 B]CARBAZOLE; AROMATIC HYDROCARBON RECEPTOR; BILIRUBIN; BILIVERDIN; CARBAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CIS ACTING ELEMENT; CYTOCHROME P450; INDOLEACETIC ACID; LIPOXIN A; TRANS ACTING FACTOR; TRYPTAMINE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

BINDING AFFINITY; BINDING SITE; DNA RESPONSIVE ELEMENT; ENZYME INDUCTION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN FUNCTION; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; THERMODYNAMICS; TRANSCRIPTION REGULATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION;

EID: 27544434863     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.162     Document Type: Review

References (53)

1. D.R. Nelson, http://drnelson.utmem.edu/CytochromeP450.html.
2. D.R. Nelson P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature Pharmacogenetics 6 1996 1 42
3. P. Honkakoski, and M. Negishi Regulation of cytochrome P450 (CYP) by nuclear receptors Biochem. J. 347 2000 321 337
4. D.J. Waxman P450 gene induction by structurally diverse xenochemicals: contral role of nuclear receptors CAR, PXR and PPAR Arch. Biochem. Biophys. 369 1999 11 23
5. O. Hankinson The aryl hydrocarbon receptor complex Annu. Rev. Pharmacol. Toxicol. 35 1995 307 340
6. J. Mimura, and Y. Fujii-Kuriyama Functional role of AhR in the expression of toxic effects by TCDD Biochim. Biophys. Acta 1619 2003 263 268
7. F.J. Gonzalez, and S. Kimura Study of P450 function using gene knockout and transgenic mice Arch. Biochem. Biophys. 409 2003 153 158
8. J.J. Floranta, and G.A. Kullak-Ublick Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism Arch. Biochem. Biophys. 433 2005 397 412
9. O. Hankinson Role of coactivators in transcriptional activation of the aryl hydrocarbon receptor Arch. Biochem. Biophys. 433 2005 379 386
10. S.A. Kliewer, B. Goodwin, and T.M. Willson The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism Endocr. Rev. 23 2002 687 702
11. K. Swales, and M. Negishi CAR, driving into the future Mol. Endocr. 18 2004 1589 1598
12. Ü. Savas, K.J. Griffin, and E.F. Johnson Molecular mechanisms of cytochrome P-450 induction by xenobiotics: an expanded role for nulear hormone receptors Mol. Pharmachol. 56 1999 851 857
13. T.A. Gasiewicz, A.S. Kende, G. Rucci, B. Whitney, and J.J. Willey Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones and related compounds Biochem. Pharmacol. 52 1996 1787 1803
14. M.S. Denison, A. Pandini, S.R. Nagy, E.P. Baldwin, and L. Bonati Ligand binding and activation of the Ah receptor Chem. Biol. Interact. 141 2002 3 24
15. M.E. Hahn Aryl hydrocarbon receptors: diversity and evolution Chem. Biol. Interact. 141 2002 131 160
16. S. Heath-Pagliuro, W.J. Rogers, K. Tullis, S.D. Seidl, P.H. Cenijn, A. Brouwer, and M.S. Denison Activation of the Ah receptor by tryptophan and tryptophan metabolites Biochemistry 37 1998 11508 11515
17. D. Phelan, G.M. Winter, W.J. Rogers, J.C. Lam, and M.S. Denison Activation of Ah receptor signal transduction pathway by bilirubin and biliverdin Arch. Biochem. Biophys. 357 1998 153 163
18. C.M. Schaldach, J. Riby, and L.F. Bjeldanes Lipoxin A4: a new class of ligand for the Ah receptor Biochemistry 38 1999 7594 7600
19. Y.D. Wei, H. Helleberg, U. Rannug, and A. Rannug Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formyl indolo[3,2-b]carbazole Chem. Biol. Interact. 110 1998 39 55
20. C.M. Sadek, and B.L. Allen-Hoffmann Suspension-mediated induction of Hepa 1c1c7 CYP1a-1 expression dependent on the Ah receptor signal transduction palthway J. Biol. Chem. 269 1994 31505 31509
21. C.M. Sadek, and B.L. Allen-Hoffmann Cytochrome P450 1A1 is rapidly induced in normal humen keratinocytes in the absence of xenobiotics J. Biol. Chem. 269 1994 16067 16074
22. Y.C. Cho, W. Zheng, and C.R. Jefcoate Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts Toxicol. Appl. Pharmacol. 199 2004 220 238
23. T. Ikuta, Y. Kobayashi, and K. Kawajiri Cell density regulates intracellar localization of aryl hydrocarbon receptor J. Biol. Chem. 279 2004 19209 19216
24. A. Puga, Y. Xia, and C. Elferink Role of the aryl hydrocarbon receptor in cell cycle regulation Chem. Biol. Interact. 141 2002 117 130
25. N. Dzeletovic, J. McGuire, M. Daujat, J. Tholander, M. Ema, Y. Fujii-Kuriyama, J. Bergman, P. Maurel, and L. Poellinger Regulation of dioxin receptor function by omeprazole J. Biol. Chem. 272 1997 12705 12713
26. M. Backlund, and M. Ingelman-Sundberg Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases Cell. Signal. 17 2005 39 48
27. A. Fujisawa-Sehara, K. Sogawa, M. Yamane, and Y. Fujii-Kuriyama Characterization of xenobiotic responsive elements upstreams from the drug-metabolizing cytochrome P450C: a similarity to glucocarticoid regulatory elements Nucleic Acids. Res. 15 1987 4179 4191
28. E.S. Shen, and J.P. Whitlock Jr. Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor J. Biol. Chem. 267 1992 6815 6819
29. L. Zhang, U. Sawas, D.L. Alexander, and C.R. Jefcoate Characterization of the mouse CYP1B1 gene Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression J. Biol. Chem. 273 1998 5174 5183
30. K. Kurose, M. Tohkin, and M. Fukuhara A novel positive regulatory element that enhances hamster CYP2A8 gene expression mediated by xenobiotic responsive element Mol. Pharmacol. 55 1999 279 287
31. T. Baba, J. Mimura, N. Nakamura, N. Harada, M. Yamamoto, K. Morohashi, Y. Fujii-Kuriyama, Intrinsic function of Ah (dioxin) receptor as a key factor in female reproduction, Mol. Cell. Biol. 25 (Nov.).
32. J. Corchero, S. Pimprole, S. Kimura, and F.J. Gonzalez Organization of the CYP1A cluster on human chromosome 15: implication for gene regulation Pharmacogenetics 11 2001 1 6
33. J. Mimura, K. Yamashita, K. Nakamura, M. Morita, T.N. Takagi, K. Nakano, M. Ema, K. Sogawa, M. Yasuda, M. Katsuki, and Y. Fujii-Kuriyama Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor Genes Cells 2 1997 645 654
34. K. Sogawa, K. Numayama-Tsuruta, T. Takahashi, N. Matsushita, C. Miura, J. Nikawa, O. Gotoh, Y. Kikuchi, and Y. Fujii-Kuriyama A novel induction mechanism of the rat CYP1A2 gene mediated by Ah receptor-Arnt heterodimer Biochem. Biophys. Res. Commun. 318 2004 746 755
35. F. Ohtake, K. Takeyama, T. Matsumoto, H. Kitagawa, Y. Yamamoto, K. Nohara, C. Tohyama, A. Krust, J. Mimura, P. Chambon, J. Yanagisawa, Y. Fujii-Kuriyama, and S. Kato Modulation of oestrogen receptor signalling by association with the activated dioxin receptor Nature 423 2003 545 550
36. S. Brunnberg, K. Pettersson, E. Rydin, J. Matthews, A. Hanberg, and I. Pongratz The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription Proc. Natl. Acad. Sci. USA 100 2003 6517 6522
37. K. Kurose, M. Tohkin, and R. Hasegawa Transcription factor NF2d9 (LBP-1a) interacts with the positive regulatory element for the xenobiotic responsive element Biochim. Biophys. Acta 1727 2005 141 144
38. A. Kobayashi, K. Sogawa, and Y. Fujii-Kuriyama Cooperative interaction between AhR.Arnt and Sp1 for drug-inducible expression of CYP1A1 gene J. Biol. Chem. 271 1996 12310 123106
39. A. Poland, E. Glober, and A.S. Kende Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase J. Biol. Chem. 251 1976 4936 4946
40. A. Fujisawa-Sehara, M. Yamane, and Y. Fujii-Kuriyama A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus Proc. Natl. Acad. Sci. USA 85 1988 7486 7490
41. M. Ema, K Sogawa, N. Watanabe, Y. Chujo, N. Matsushita, O. Gotoh, Y. Funae, and Y. Fujii-Kuriyama cDNA cloning and structure of mouse putative Ah receptor Biochem. Biophys. Res. Commun. 184 1992 246 253
42. K.M. Burbach, A. Poland, and C.A. Bradfield Cloning of Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor Proc. Natl. Acad. Sci. USA 89 1992 8185 8189
43. A. Kobayashi, K Numayama-Tsuruta, K. Sogawa, and Y. Fujii-Kuriyama CBP/p300 function as possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt) J. Biochem. 122 1997 703 710
44. M.B. Kumar, and G.H. Perdew Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential Gene Expr. 8 1999 273 286
45. T.V. Beischlag, S. Wang, D.W. Rose, J. Torchia, K. Reisz-Porszasz, W.E. Muhammad, W.E. Nelson, M.R. Probst, O. Rosenfeld, and O. Hankinson Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex Mol. Cell. Biol. 22 2002 4319 4333
46. J.E. Morgan, and J.P. Whitlock Jr. Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin Proc. Natl. Acad. Sci. USA 89 1992 11622 11626
47. S. Wang, and O. Hankinson Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex J. Biol. Chem. 277 2002 11821 11827
48. S. Wang, K. Ge, R.G. Roeder, and O. Hankinson Role of mediator in transcriptional activation by the aryl hydrocarbon receptor J. Biol. Chem. 279 2004 13593 13600
49. R.S. Pollenz The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation Chem. Biol. Interact. 141 2002 41 61
50. N.A. Davarinos, and R.S. Pollenz Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytoplasmic proteasome following nuclear export J. Biol. Chem. 274 1999 28708 28715
51. B.J. Roberts, and M.L. Whitelaw Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway J. Biol. Chem. 274 1999 36351 36356
52. M.J. Lees, D.J. Peet, and M.L. Whitelaw Defining the role for XAP2 in stabilization of the dioxin receptor J. Biol. Chem. 278 2003 35878 35888
53. J. Mimura, M. Ema, K. Sogawa, and Y. Fujii-Kuriyama Identification of a novel mechanism of regulation of Ah (dioxin) receptor function Genes Dev. 13 1999 20 25