A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction

Biochemical Journal

Volumn 401, Issue 3, 2007, Pages 735-741

  Shindo, Sawako ^a   Numazawa, Satoshi ^a   Yoshida, Takemi ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

AMP activated protein kinase (AMPK); Constitutive androstane receptor (CAR); Cytochrome P450 (CYP); Gene expression; Nuclear receptor; Nuclear translocation

Indexed keywords

ACTIVATION ANALYSIS; CELL CULTURE; ENZYME KINETICS; GENES; GENETIC ENGINEERING; PHYSIOLOGICAL MODELS;

AMP-ACTIVATED PROTEIN KINASE (AMPK); CONSTITUTIVE ANDROSTANE RECEPTOR (CAR); CYTOCHROME P450 (CYP); GENE EXPRESSIONS; NUCLEAR RECEPTOR; NUCLEAR TRANSLOCATION;

PROTEINS;

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PHENOBARBITAL; PROTEIN SERINE THREONINE KINASE INHIBITOR; THREONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; GENE TRANSLOCATION; IMMUNOBLOTTING; LIVER; MALE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALS; CYTOCHROME P-450 CYP2B1; ENZYME INDUCTION; LIVER; MALE; MICE; MICE, INBRED C3H; MULTIENZYME COMPLEXES; PHENOBARBITAL; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, INBRED F344; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

MUS; RATTUS;

EID: 33846886331     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061238     Document Type: Article

References (45)

1. Forman, B. M., Tzameli, I., Choi, H. S., Chen, J., Simha, D., Seol, W., Evans, R. M. and Moore, D. D. (1998) Androstane metabolites bind to and deactivate the nuclear receptor CAR-β. Nature 395, 612-615
2. Honkakoski, P., Zelko, I., Sueyoshi, T. and Negishi, M. (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell. Biol. 18, 5652-5658
3. Pascussi, J. M., Dvorak, Z., Gerbal-Chaloin, S., Assenat, E., Maurel, P. and Vilarem, M. J. (2003) Pathophysiological factors affecting CAR gene expression. Drug Metab. Rev. 35, 255-268
4. Kawamoto, T., Sueyostii, T., Zelko, I., Moore, R., Washburn, K. and Negishi, M. (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell. Biol. 19, 6318-6322
5. Tzameli, I., Pissios, P., Schuetz, E. G. and Moore, D. D. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell. Biol. 20, 2951-2958
6. Kawamura, A., Yoshida, Y., Kimura, N., Oda, H. and Kakinuma, A. (1999) Biochem. Biophys. Res. Commun. 264, 530-536
7. Rutter, G. A., da Silva Xavier, G. and Leclerc, I. (2003) Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem. J. 375, 1-16
8. Kahn, B. B., Alquier, T., Carling, D. and Hardie, D. G. (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25
9. Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. and Wolf, C. R. (2005) AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J. Biol. Chem. 280, 4367-4373
10. Blouin, R. A., Bandyopadhyay, A. M., Chaudhary, I., Robertson, L. W., Gemzik, B. and Parkinson, A. (1993) Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: molecular characterization. Arch. Biochem. Biophys. 303, 313-320
11. Zangar, R. C. and Novak, R. F. (1997) Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes. Arch. Biochem. Biophys. 337, 217-224
12. Yoshida, Y., Kimura, N., Oda, H. and Kakinuma, A. (1996) Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. Biochem. Biophys. Res. Commun. 229, 182-188
13. Numazawa, S., Shindo, S., Maruyama, K., Chibana, R, Kawahara, Y., Ashino, T., Tanaka, S. and Yoshida, T. (2005) Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital. FEBS Lett. 579, 3560-3564
14. Sakoda, H., Ogihara, T., Anai, M., Fujishiro, M., Ono, H., Onishi, Y., Katagiri, H., Abe, M., Fukushima, Y., Shojima, N. et al. (2002) Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Am. J. Physiol. Endocrinol. Metab. 282, E1239-E1244
15. Omura, T. and Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239, 2370-2378
16. Oguro, T., Kaneko, E., Numazawa, S., Imaoka, S., Funae, Y. and Yoshida, T. (1997) Induction of hepatic heme oxygenase and changes in cytochrome P-450s in response to oxidative stress produced by stilbenes and stilbene oxides in rats. J. Pharmacol. Exp. Ther. 280, 1455-1462
17. Maehara, Y., Fujiyoshi, T., Takahashi, K., Yamamoto, M. and Endo, H. (1985) 1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro. Biochem. Biophys. Res. Commun. 131, 800-805
18. Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. and Hardie, D. G. (2003) Complexes between the LKB1 tumor suppressor, STRADα/β and M025α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28
19. Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M. and Carling, D. (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13, 2004-2008
20. 485/491. J. Biol. Chem. 281, 5335-5340
21. Hoen, P. A., Bijsterbosch, M. K., van Berkel, T. J., Vermeulen, N. P. and Commandeur, J. N. (2001) Midazolam is a phenobarbital-like cytochrome P450 inducer in rats. J. Pharmacol. Exp. Ther. 299, 921-927
22. Musi, N., Hayashi, T., Fujii, N., Hirshman, M. F., Witters, L. A. and Goodyear, L. J. (2001) AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 280, E677-E684
23. Hardie, D. G. and Carling, D. (1997) The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur. J. Biochem. 246, 259-273
24. Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N. et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167-1174
25. Kodama, S., Koike, C., Negishi, M. and Yamamoto, Y. (2004) Nuclear receptors CAR and PXR cross talk with FOX01 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol. Cell. Biol. 24, 7931-7940
26. Sidhu, J. S. and Omiecinski, C. J. (1997) An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J. Pharmacol. Exp. Ther. 282, 1122-1129
27. Marc, N., Galisteo, M., Lagadic-Gossmann, D., Fautrel, A., Joannard, F., Guillouzo, A. and Corcos, L. (2000) Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture: involvement of calcium- and cAMP-dependent pathways. Eur. J. Biochem. 267, 963-970
28. Koo, S. H., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P. et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-1111
29. Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S. H., Bardeesy, N., Depinho, R. A., Montminy, M. and Cantley, L. C. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642-1646
30. Screaton, R. A., Conkright, M. D., Katoh, Y., Best, J. L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, 3rd, J. R., Takemori, H. et al. (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119, 61-74
31. Katoh, Y., Takemori, H., Horike, N., Doi, J., Muraoka, M., Min, L. and Okamoto, M. (2004) Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. Mol. Cell. Endocrinol. 217, 109-112
32. Sidhu, J. S. and Omiecinski, C. J. (1995) cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. J. Biol. Chem. 270, 12762-12773
33. Galisteo, M., Marc, N., Fautrel, A., Guillouzo, A., Corcos, L. and Lagadic-Gossmann, D. (1999) Involvement of cyclic nucleotide- and calcium-regulated pathways in phenobarbital-induced cytochrome P-450 3A expression in mouse primary hepatocytes. J. Pharmacol. Exp. Ther. 290, 1270-1277
34. Yamamoto, Y., Kawamoto, T. and Negishi, M. (2003) The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch. Biochem. Biophys. 409, 207-211
35. Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. and Hardie, D. G. (2005) Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2, 9-19
36. 2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem. 280, 29060-29066
37. 2+/calmodulin- dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2, 21-33
38. Lasky, T. and Magder, L. (1997) Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure? Environ. Health Perspect. 105, 392-397
39. Inoki, K., Corradetti, M. N. and Guan, K. L. (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet. 37, 19-24
40. Ashrafian, H. (2006) Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis. Lancet 367, 618-621
41. Sakoda, H., Fujishiro, M., Fujio, J., Shojima, N., Ogihara, I, Kushiyama, A., Fukushima, Y., Anai, M., Ono, H., Kikuchi, M. et al. (2005) Glycogen debranching enzyme association with β-subunit regulates AMP-activated protein kinase activity. Am. J. Physiol. Endocrinol. Metab. 289, E474-E481
42. Joannard, F., Rissel, M., Gilot, D., Anderson, A., Orfila-Lefeuvre, L., Guillouzo, A., Atfi, A. and Lagadic-Gossmann, D. (2006) Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes. Toxicol. Lett. 161, 61-72
43. Chan, A. Y. and Dyck, J. R. (2005) Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy. Can. J. Physiol. Pharmacol. 83, 24-28
44. Sarbassov, D. D., Ali, S. M. and Sabatini, D. M. (2005) Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603
45. Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P. and Pandolfi, P. P. (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193