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Volumn 32, Issue 3, 2004, Pages 281-290

Glucuronidation and the UDP-glucuronosyltransferases in health and disease

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BENZO[A]PYRENE; BILIRUBIN; CYTOCHROME P450; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA; ESTRADIOL; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; ISOENZYME; NITROSAMINE; NUCLEAR FACTOR I; OLTIPRAZ; PARACETAMOL; PHENOBARBITAL; POLYCYCLIC AROMATIC HYDROCARBON; PROSTAGLANDIN SYNTHASE; TRANSCRIPTION FACTOR; VIRUS VECTOR; XENOBIOTIC AGENT;

EID: 10744227696     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.3.281     Document Type: Conference Paper
Times cited : (219)

References (103)
  • 1
    • 0031719562 scopus 로고    scopus 로고
    • Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: A common missense mutation among Japanese, Koreans and Chinese
    • Akaba K, Kimura T, Sasaki A, Tanabe S, Ikegami T, Hashimoto M, Umeda H, Yoshida H, Umetsu K, Chiba H, et al. (1998) Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem Mol Biol Int 46:21-26.
    • (1998) Biochem Mol Biol Int , vol.46 , pp. 21-26
    • Akaba, K.1    Kimura, T.2    Sasaki, A.3    Tanabe, S.4    Ikegami, T.5    Hashimoto, M.6    Umeda, H.7    Yoshida, H.8    Umetsu, K.9    Chiba, H.10
  • 2
    • 0030669869 scopus 로고    scopus 로고
    • Chromosomal localization, structure and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme
    • Beaulieu M, Levesque E, Tchernof A, Beatty BG, Belanger A, and Hum DW (1997) Chromosomal localization, structure and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. DNA Cell Biol 16:1143-1154.
    • (1997) DNA Cell Biol , vol.16 , pp. 1143-1154
    • Beaulieu, M.1    Levesque, E.2    Tchernof, A.3    Beatty, B.G.4    Belanger, A.5    Hum, D.W.6
  • 3
    • 0032817021 scopus 로고    scopus 로고
    • Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1
    • Bernard P, Goudonnet H, Artur Y, Desvergne B, and Wahli W (1999) Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1. Mol Pharmacol 56:526-536.
    • (1999) Mol Pharmacol , vol.56 , pp. 526-536
    • Bernard, P.1    Goudonnet, H.2    Artur, Y.3    Desvergne, B.4    Wahli, W.5
  • 4
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
    • Beutler E, Gelbart T, and Demina A (1998) Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 95:8170-8174.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 6
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase I in Gilbert's syndrome
    • Bosma PJ, Roy Chowdhury J, and Bakker C (1995) The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase I in Gilbert's syndrome. New Engl J Med 333: 1171-1175.
    • (1995) New Engl J Med , vol.333 , pp. 1171-1175
    • Bosma, P.J.1    Roy Chowdhury, J.2    Bakker, C.3
  • 8
    • 0030699360 scopus 로고    scopus 로고
    • Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: Pharmacological implications
    • Ciotti M, Marrone A, Potter C, and Owens IS (1997) Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Pharmacogenetics 7:485-495.
    • (1997) Pharmacogenetics , vol.7 , pp. 485-495
    • Ciotti, M.1    Marrone, A.2    Potter, C.3    Owens, I.S.4
  • 9
    • 0031894377 scopus 로고    scopus 로고
    • The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
    • Coffman BL, King CD, Rios GR, and Tephly TR (1998) The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metab Dispos 26:73-77.
    • (1998) Drug Metab Dispos , vol.26 , pp. 73-77
    • Coffman, B.L.1    King, C.D.2    Rios, G.R.3    Tephly, T.R.4
  • 10
    • 0035197725 scopus 로고    scopus 로고
    • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms
    • Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, and Mackenzie PI (2001) Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 299:998-1006.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 998-1006
    • Court, M.H.1    Duan, S.X.2    Von Moltke, L.L.3    Greenblatt, D.J.4    Patten, C.J.5    Miners, J.O.6    Mackenzie, P.I.7
  • 11
    • 0025732951 scopus 로고
    • Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation
    • Davies MH and Schnell RC (1991) Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation. Toxicol Appl Pharmacol 109:29-40.
    • (1991) Toxicol Appl Pharmacol , vol.109 , pp. 29-40
    • Davies, M.H.1    Schnell, R.C.2
  • 12
    • 0026485794 scopus 로고
    • Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in UDP-glucuronosyltransferase
    • de Morais SMF, Chow SYM, and Wells PG (1992a) Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in UDP-glucuronosyltransferase. Toxicol Appl Pharmacol 117:81-87.
    • (1992) Toxicol Appl Pharmacol , vol.117 , pp. 81-87
    • De Morais, S.M.F.1    Chow, S.Y.M.2    Wells, P.G.3
  • 13
    • 0026545451 scopus 로고
    • Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome
    • de Morais SMF, Uetrecht JP, and Wells PG (1992b) Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome. Gastroenterology 102:577-586.
    • (1992) Gastroenterology , vol.102 , pp. 577-586
    • De Morais, S.M.F.1    Uetrecht, J.P.2    Wells, P.G.3
  • 14
    • 0023774958 scopus 로고
    • Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity
    • de Morais SMF and Wells PG (1988) Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity. J Pharmacol Exp Ther 247:323-331.
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 323-331
    • De Morais, S.M.F.1    Wells, P.G.2
  • 15
    • 0024323307 scopus 로고
    • Enhanced acetaminophen toxicity in rats with bilirubin UDP-glucuronyl transferase deficiency
    • de Morais SMF and Wells PG (1989) Enhanced acetaminophen toxicity in rats with bilirubin UDP-glucuronyl transferase deficiency. Hepatology 10:163-167.
    • (1989) Hepatology , vol.10 , pp. 163-167
    • De Morais, S.M.F.1    Wells, P.G.2
  • 16
    • 0027521059 scopus 로고
    • Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol
    • Ebner T, Remmel RP, and Burchell B (1993) Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol. Mol Pharmacol 43:649-654.
    • (1993) Mol Pharmacol , vol.43 , pp. 649-654
    • Ebner, T.1    Remmel, R.P.2    Burchell, B.3
  • 17
    • 0345211459 scopus 로고    scopus 로고
    • Heterogeneity of paracetamol metabolism in Gilbert's syndrome
    • Esteban A and Perez-Mateo M (1999) Heterogeneity of paracetamol metabolism in Gilbert's syndrome. Eur J Drug Metab Pharmacokinet 24:9-13.
    • (1999) Eur J Drug Metab Pharmacokinet , vol.24 , pp. 9-13
    • Esteban, A.1    Perez-Mateo, M.2
  • 18
    • 0036532140 scopus 로고    scopus 로고
    • Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes
    • Fang JL, Beland FA, Doerge DR, Wiener D, Guillemette C, Marques MM, and Lazarus P (2002) Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. Cancer Res 62:1978-1986.
    • (2002) Cancer Res , vol.62 , pp. 1978-1986
    • Fang, J.L.1    Beland, F.A.2    Doerge, D.R.3    Wiener, D.4    Guillemette, C.5    Marques, M.M.6    Lazarus, P.7
  • 20
    • 0036110301 scopus 로고    scopus 로고
    • Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers
    • Gestl SA, Green MD, Shearer DA, Frauenhoffer E, Tephly TR, and J Weisz (2002) Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers. Am J Pathol 160:1467-1479.
    • (2002) Am J Pathol , vol.160 , pp. 1467-1479
    • Gestl, S.A.1    Green, M.D.2    Shearer, D.A.3    Frauenhoffer, E.4    Tephly, T.R.5    Weisz, J.6
  • 21
    • 1342317392 scopus 로고    scopus 로고
    • Haplotypic structure of the carcinogen-metabolizing enzyme UGT1A7: Nine polymorphic alleles (*1 through *9)
    • Abstract 7485, April 11-15, San Diego, CA
    • Girard H, Journault K, and Guillemette C (2003) Haplotypic structure of the carcinogen-metabolizing enzyme UGT1A7: nine polymorphic alleles (*1 through *9). Abstract 7485, in ASPET, Experimental Biology 2003, April 11-15, 2003, San Diego, CA.
    • (2003) ASPET, Experimental Biology 2003
    • Girard, H.1    Journault, K.2    Guillemette, C.3
  • 23
    • 0034518551 scopus 로고    scopus 로고
    • Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter
    • Gregory PA, Hansen AJ, and Mackenzie PI (2000) Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics 10:809-820.
    • (2000) Pharmacogenetics , vol.10 , pp. 809-820
    • Gregory, P.A.1    Hansen, A.J.2    Mackenzie, P.I.3
  • 24
    • 0031038167 scopus 로고    scopus 로고
    • Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol
    • Grove AD, Kessler FK, Metz RP, and Ritter JK (1997) Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol. J Biol Chem 272:1621-1627.
    • (1997) J Biol Chem , vol.272 , pp. 1621-1627
    • Grove, A.D.1    Kessler, F.K.2    Metz, R.P.3    Ritter, J.K.4
  • 25
    • 0033972277 scopus 로고    scopus 로고
    • Differential protection by rat UDP-glucuronosyltransferase 1A7 against benzo[a]pyrene-3,6-quinone-versus benzo[a]pyrene-induced cytotoxic effects in human lymphoblastoid cells
    • Grove AD, Llewellyn GC, Kessler FK, White KL, Crespi CL, and Ritter JK (2000) Differential protection by rat UDP-glucuronosyltransferase 1A7 against benzo[a]pyrene-3,6-quinone-versus benzo[a]pyrene-induced cytotoxic effects in human lymphoblastoid cells. Toxicol Appl Pharmacol 162:34-43.
    • (2000) Toxicol Appl Pharmacol , vol.162 , pp. 34-43
    • Grove, A.D.1    Llewellyn, G.C.2    Kessler, F.K.3    White, K.L.4    Crespi, C.L.5    Ritter, J.K.6
  • 27
    • 0036322035 scopus 로고    scopus 로고
    • Long-term normalization of serum bilirubin levels by massive repopulation of Gunn rat liver by normal hepatocytes, transplanted after preparative hepatic irradiation and partial hepatectomy
    • Guha C, Parashar B, Deb NJ, Garg M, Gorla GR, Singh A, Roy-Chowdhury N, Vikram B, and Roy-Chowdhury J (2002) Long-term normalization of serum bilirubin levels by massive repopulation of Gunn rat liver by normal hepatocytes, transplanted after preparative hepatic irradiation and partial hepatectomy. Hepatology 36:354-362.
    • (2002) Hepatology , vol.36 , pp. 354-362
    • Guha, C.1    Parashar, B.2    Deb, N.J.3    Garg, M.4    Gorla, G.R.5    Singh, A.6    Roy-Chowdhury, N.7    Vikram, B.8    Roy-Chowdhury, J.9
  • 30
    • 0030991972 scopus 로고    scopus 로고
    • Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells
    • Guillemette C, Levesque E, Beaulieu M, Turgeon D, Hum DW, and Belanger A (1997) Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells. Endocrinology 138:2998-3005.
    • (1997) Endocrinology , vol.138 , pp. 2998-3005
    • Guillemette, C.1    Levesque, E.2    Beaulieu, M.3    Turgeon, D.4    Hum, D.W.5    Belanger, A.6
  • 31
    • 0034652640 scopus 로고    scopus 로고
    • Genetic polymorphisms in UGT1A1 and association with breast cancer among African Americans
    • Guillemette C, Millikan R, Newman B, and Housman DE (2000a) Genetic polymorphisms in UGT1A1 and association with breast cancer among African Americans. Cancer Res 60:950-956.
    • (2000) Cancer Res , vol.60 , pp. 950-956
    • Guillemette, C.1    Millikan, R.2    Newman, B.3    Housman, D.E.4
  • 32
    • 0033789766 scopus 로고    scopus 로고
    • Structural heterogeneity at the UDP-glucuronosyltransferase 1A locus: Functional consequences of three novel missense mutations in the human UGT1A7 gene
    • Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, and Housman DE (2000b) Structural heterogeneity at the UDP-glucuronosyltransferase 1A locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 10:629-644.
    • (2000) Pharmacogenetics , vol.10 , pp. 629-644
    • Guillemette, C.1    Ritter, J.K.2    Auyeung, D.J.3    Kessler, F.K.4    Housman, D.E.5
  • 33
    • 0037819284 scopus 로고    scopus 로고
    • Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
    • Guillemette CG (2003) Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenom J 3:136-158.
    • (2003) Pharmacogenom J , vol.3 , pp. 136-158
    • Guillemette, C.G.1
  • 34
    • 0025912865 scopus 로고
    • Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation
    • Gupta S, Aragona E, Vemuru RP, Bhargava KK, Burk RD, and Chowdhury JR (1991) Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology 14:144-149.
    • (1991) Hepatology , vol.14 , pp. 144-149
    • Gupta, S.1    Aragona, E.2    Vemuru, R.P.3    Bhargava, K.K.4    Burk, R.D.5    Chowdhury, J.R.6
  • 36
    • 0032718482 scopus 로고    scopus 로고
    • Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates
    • Hall D, Ybazeta G, Destro-Bisol G, Petzl-Erler ML, and Di Rienzo A (1999) Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates. Pharmacogenetics 9:591-599.
    • (1999) Pharmacogenetics , vol.9 , pp. 591-599
    • Hall, D.1    Ybazeta, G.2    Destro-Bisol, G.3    Petzl-Erler, M.L.4    Di Rienzo, A.5
  • 37
    • 0031056594 scopus 로고    scopus 로고
    • HNF1 alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter
    • Hansen AJ, Lee YH, Gonzalez FJ, and Mackenzie PI (1997) HNF1 alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter. DNA Cell Biol 16:207-214.
    • (1997) DNA Cell Biol , vol.16 , pp. 207-214
    • Hansen, A.J.1    Lee, Y.H.2    Gonzalez, F.J.3    Mackenzie, P.I.4
  • 39
    • 0025771648 scopus 로고
    • Isolation, sequence and developmental expression of rat UGT2B2: The gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone
    • Haque SJ, Petersen DD, Nebert DW, and Mackenzie PI (1991) Isolation, sequence and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone. DNA Cell Biol 10:515-524.
    • (1991) DNA Cell Biol , vol.10 , pp. 515-524
    • Haque, S.J.1    Petersen, D.D.2    Nebert, D.W.3    Mackenzie, P.I.4
  • 40
    • 0026706445 scopus 로고
    • In vitro and in vivo biotransformation and covalent binding of benzo(a)pyrene in rats with a genetic deficiency in bilirubin UDP-glucuronosyltransferase
    • Hu Z and Wells PG (1992) In vitro and in vivo biotransformation and covalent binding of benzo(a)pyrene in rats with a genetic deficiency in bilirubin UDP-glucuronosyltransferase. J Pharmacol Exp Ther 263:334-342.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 334-342
    • Hu, Z.1    Wells, P.G.2
  • 41
    • 1342296285 scopus 로고
    • Human interindividual variation in lymphocyte UDP-glucuronosyltransferases as a determinant of benzo[a]pyrene covalent binding and cytotoxicity
    • Hu Z and Wells PG (1993) Human interindividual variation in lymphocyte UDP-glucuronosyltransferases as a determinant of benzo[a]pyrene covalent binding and cytotoxicity. ISSX Proc 4:241.
    • (1993) ISSX Proc , vol.4 , pp. 241
    • Hu, Z.1    Wells, P.G.2
  • 42
    • 0028070481 scopus 로고
    • Modulation of benzo[a]pyrene bioactivation and cytotoxicity by glucuronidation in lymphocytes and hepatic microsomes from rats with a hereditary deficiency in bilirubin UDP-glucuronosyltransferase
    • Hu Z and Wells PG (1994) Modulation of benzo[a]pyrene bioactivation and cytotoxicity by glucuronidation in lymphocytes and hepatic microsomes from rats with a hereditary deficiency in bilirubin UDP-glucuronosyltransferase. Toxicol Appl Pharmacol 127:306-313.
    • (1994) Toxicol Appl Pharmacol , vol.127 , pp. 306-313
    • Hu, Z.1    Wells, P.G.2
  • 44
    • 0029559174 scopus 로고
    • Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies
    • Ikushiro S, Emi Y, and Iyanagi T (1995) Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies. Arch Biochem Biophys 324:267-272.
    • (1995) Arch Biochem Biophys , vol.324 , pp. 267-272
    • Ikushiro, S.1    Emi, Y.2    Iyanagi, T.3
  • 45
    • 0029849639 scopus 로고    scopus 로고
    • Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats
    • Ilan Y, Attavar P, Takahashi M, Davidson A, Horwitz M, Guida J, Roy Chowdhury N, and Roy Chowdhury J (1996) Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Investig 98:2640-2647.
    • (1996) J Clin Investig , vol.98 , pp. 2640-2647
    • Ilan, Y.1    Attavar, P.2    Takahashi, M.3    Davidson, A.4    Horwitz, M.5    Guida, J.6    Roy Chowdhury, N.7    Roy Chowdhury, J.8
  • 47
    • 0034057412 scopus 로고    scopus 로고
    • Octamer transcription factor-1 enhances hepatic nuclear factor-1 alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter
    • Ishii Y, Hansen AJ, and Mackenzie PI (2000) Octamer transcription factor-1 enhances hepatic nuclear factor-1 alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. Mol Pharmacol 57:940-947.
    • (2000) Mol Pharmacol , vol.57 , pp. 940-947
    • Ishii, Y.1    Hansen, A.J.2    Mackenzie, P.I.3
  • 48
    • 0032413678 scopus 로고    scopus 로고
    • Biochemical and molecular aspects of genetic disorders of bilirubin metabolism
    • Iyanagi T, Emi Y, and Ikushiro S (1998) Biochemical and molecular aspects of genetic disorders of bilirubin metabolism. Biochim Biophys Acta 1407:173-174.
    • (1998) Biochim Biophys Acta , vol.1407 , pp. 173-174
    • Iyanagi, T.1    Emi, Y.2    Ikushiro, S.3
  • 49
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer L, King CD, Whitington PF, Green MD, Roy SK, Tephly TR, Coffman BL, and Ratain MJ (1998) Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Investig 101:847-854.
    • (1998) J Clin Investig , vol.101 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Roy, S.K.5    Tephly, T.R.6    Coffman, B.L.7    Ratain, M.J.8
  • 50
    • 0034623009 scopus 로고    scopus 로고
    • Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates
    • Izsvák Z, Ivics Z, and Plasterk RH (2000) Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates. J Mol Biol 302:93-102.
    • (2000) J Mol Biol , vol.302 , pp. 93-102
    • Izsvák, Z.1    Ivics, Z.2    Plasterk, R.H.3
  • 53
    • 0036178106 scopus 로고    scopus 로고
    • Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases
    • Kessler FK, Kessler MR, Auyeung DJ, and Ritter JK (2002) Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug Metab Dispos 30:324-330.
    • (2002) Drug Metab Dispos , vol.30 , pp. 324-330
    • Kessler, F.K.1    Kessler, M.R.2    Auyeung, D.J.3    Ritter, J.K.4
  • 54
    • 0031410745 scopus 로고    scopus 로고
    • Induction of a rat liver benzo[a]pyrene-trans-7,8-dihydrodiol glucuronidating activity by oltipraz and beta-naphthoflavone
    • Kessler FK and Ritter JK (1997) Induction of a rat liver benzo[a]pyrene-trans-7,8-dihydrodiol glucuronidating activity by oltipraz and beta-naphthoflavone. Carcinogenesis 18:107-114.
    • (1997) Carcinogenesis , vol.18 , pp. 107-114
    • Kessler, F.K.1    Ritter, J.K.2
  • 55
    • 0030837889 scopus 로고    scopus 로고
    • Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation
    • Kim PM, DeBoni U, and Wells PG (1997a) Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[a]pyrene-initiated micronucleus formation. Free Radic Biol Med 23:579-596.
    • (1997) Free Radic Biol Med , vol.23 , pp. 579-596
    • Kim, P.M.1    DeBoni, U.2    Wells, P.G.3
  • 56
    • 0029863728 scopus 로고    scopus 로고
    • Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene
    • Kim PM and Wells PG (1996a) Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene. Cancer Res 56: 1526-1532.
    • (1996) Cancer Res , vol.56 , pp. 1526-1532
    • Kim, P.M.1    Wells, P.G.2
  • 57
    • 0030047170 scopus 로고    scopus 로고
    • Phenytoin-initiated hydroxyl radical formation: Characterization by enhanced salicylate hydroxylation
    • Kim PM and Wells PG (1996b) Phenytoin-initiated hydroxyl radical formation: characterization by enhanced salicylate hydroxylation. Mol Pharmacol 49:172-181.
    • (1996) Mol Pharmacol , vol.49 , pp. 172-181
    • Kim, P.M.1    Wells, P.G.2
  • 58
    • 1342317394 scopus 로고    scopus 로고
    • Phenytoin embryotoxicity: Protection by UDP-glucuronosyltransferases
    • No 1288
    • Kim PM and Wells PG (1998) Phenytoin embryotoxicity: protection by UDP-glucuronosyltransferases. Toxicol Sci 42(1-S):261 (No. 1288).
    • (1998) Toxicol Sci , vol.42 , Issue.1 S , pp. 261
    • Kim, P.M.1    Wells, P.G.2
  • 59
    • 0030946410 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH)
    • Kim PM, Winn LM, Parman T, and Wells PG (1997b) UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH). J Pharmacol Exp Ther 280:200-209.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 200-209
    • Kim, P.M.1    Winn, L.M.2    Parman, T.3    Wells, P.G.4
  • 60
    • 0032535727 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase UGT1A7 induced in rat small intestinal mucosa by oral administration of 2-naphthoflavone
    • Kobayashi T, Yokota H, Ohgiya S, Iwano H, and Yuasa A (1998) UDP-glucuronosyltransferase UGT1A7 induced in rat small intestinal mucosa by oral administration of 2-naphthoflavone. Eur J Biochem 258:948-955.
    • (1998) Eur J Biochem , vol.258 , pp. 948-955
    • Kobayashi, T.1    Yokota, H.2    Ohgiya, S.3    Iwano, H.4    Yuasa, A.5
  • 62
    • 0034118356 scopus 로고    scopus 로고
    • Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)
    • Lampe JW, Bigler J, Bush AC, and Potter JD (2000). Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y). Cancer Epidemiol Biomarkers Prev 9:329-333.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 329-333
    • Lampe, J.W.1    Bigler, J.2    Bush, A.C.3    Potter, J.D.4
  • 63
    • 0032767352 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: Relationships to serum bilirubin concentrations
    • Lampe JW, Bigler J, Horner NK, and Potter JD (1999) UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations. Pharmacogenetics 9:341-349.
    • (1999) Pharmacogenetics , vol.9 , pp. 341-349
    • Lampe, J.W.1    Bigler, J.2    Horner, N.K.3    Potter, J.D.4
  • 64
    • 0030765649 scopus 로고    scopus 로고
    • Disruption of the C/Ebp-alpha gene in adult mouse liver
    • Lee YH, Sauer B, Johnson PF, and Gonzalez FJ (1997) Disruption of the C/Ebp-alpha gene in adult mouse liver. Mol Cell Biol 17:6014-6022.
    • (1997) Mol Cell Biol , vol.17 , pp. 6014-6022
    • Lee, Y.H.1    Sauer, B.2    Johnson, P.F.3    Gonzalez, F.J.4
  • 65
    • 0030795936 scopus 로고    scopus 로고
    • Isolation and characterization of UGT2B 15(Y85): A UDP-glucuronosyltransferase encoded by a polymorphic gene
    • Levesque E, Beaulieu M, Green MD, Tephly TR, Belanger A, and Hum DW (1997) Isolation and characterization of UGT2B 15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 7:317-325.
    • (1997) Pharmacogenetics , vol.7 , pp. 317-325
    • Levesque, E.1    Beaulieu, M.2    Green, M.D.3    Tephly, T.R.4    Belanger, A.5    Hum, D.W.6
  • 66
    • 0032812606 scopus 로고    scopus 로고
    • Characterization and substrate specificity of UGT2B4 (E458): A UDP-glucuronosyltransferase encoded by a polymorphic gene
    • Levesque E, Beaulieu M, Hum DW, and Belanger A (1999) Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 9:207-216.
    • (1999) Pharmacogenetics , vol.9 , pp. 207-216
    • Levesque, E.1    Beaulieu, M.2    Hum, D.W.3    Belanger, A.4
  • 67
    • 0035799361 scopus 로고    scopus 로고
    • Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase
    • Levesque EE, Turgeon D, Carrier JS, Montminy V, Beaulieu M, and Belanger A (2001) Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. Biochemistry 40:3869-3881.
    • (2001) Biochemistry , vol.40 , pp. 3869-3881
    • Levesque, E.E.1    Turgeon, D.2    Carrier, J.S.3    Montminy, V.4    Beaulieu, M.5    Belanger, A.6
  • 68
    • 0023663915 scopus 로고
    • The interplay of DNA-binding proteins on the promoter of the mouse albumin gene
    • Lichtsteiner S, Wuarin J, and Schibler U (1987) The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51:963-973.
    • (1987) Cell , vol.51 , pp. 963-973
    • Lichtsteiner, S.1    Wuarin, J.2    Schibler, U.3
  • 70
    • 0025295192 scopus 로고
    • Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter
    • Mackenzie PI and Rodbourn L (1990) Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter. J Biol Chem 265:11328-11332.
    • (1990) J Biol Chem , vol.265 , pp. 11328-11332
    • Mackenzie, P.I.1    Rodbourn, L.2
  • 71
    • 0033637811 scopus 로고    scopus 로고
    • An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer
    • MacLeod SL, Nowell S, Plaxco J, and Lang NP (2000) An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer. Ann Surg Oncol 7:777-782.
    • (2000) Ann Surg Oncol , vol.7 , pp. 777-782
    • MacLeod, S.L.1    Nowell, S.2    Plaxco, J.3    Lang, N.P.4
  • 72
    • 0033001454 scopus 로고    scopus 로고
    • Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism
    • Maruo Y, Nishizawa K, Sato H, Doida Y, and Shimada M (1999) Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism. Pediatrics 103:1224-1227.
    • (1999) Pediatrics , vol.103 , pp. 1224-1227
    • Maruo, Y.1    Nishizawa, K.2    Sato, H.3    Doida, Y.4    Shimada, M.5
  • 73
    • 0032577932 scopus 로고    scopus 로고
    • Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon
    • Mojarrabi B and Mackenzie PI (1998) Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon. Biochem Biophys Res Commun 247:704-709.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 704-709
    • Mojarrabi, B.1    Mackenzie, P.I.2
  • 74
    • 0031229611 scopus 로고    scopus 로고
    • Structure of the human Ugt2b4 gene encoding a bile acid UDP-glucuronosyltransferase
    • Monaghan G, Burchell B, and Boxer M (1997) Structure of the human Ugt2b4 gene encoding a bile acid UDP-glucuronosyltransferase. Mamm Genome 8:692-694.
    • (1997) Mamm Genome , vol.8 , pp. 692-694
    • Monaghan, G.1    Burchell, B.2    Boxer, M.3
  • 75
    • 0034960344 scopus 로고    scopus 로고
    • Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo
    • Nakai H, Yant SR, Storm TA, Fuess S, Meuse L, and Kay MA (2001) Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J Virol 75:6969-6976.
    • (2001) J Virol , vol.75 , pp. 6969-6976
    • Nakai, H.1    Yant, S.R.2    Storm, T.A.3    Fuess, S.4    Meuse, L.5    Kay, M.A.6
  • 76
    • 0026879233 scopus 로고
    • The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: Implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes
    • Owens IS and Ritter JK (1992) The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes. Pharmacogenetics 2:93-108.
    • (1992) Pharmacogenetics , vol.2 , pp. 93-108
    • Owens, I.S.1    Ritter, J.K.2
  • 79
    • 0026701911 scopus 로고
    • A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini
    • Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, and Owens IS (1992) A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257-3261.
    • (1992) J Biol Chem , vol.267 , pp. 3257-3261
    • Ritter, J.K.1    Chen, F.2    Sheen, Y.Y.3    Tran, H.M.4    Kimura, S.5    Yeatman, M.T.6    Owens, I.S.7
  • 80
    • 0032791711 scopus 로고    scopus 로고
    • Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences
    • Ritter JK, Kessler FK, Thompson MT, Grove AD, Auyeung DJ, and Fisher RA (1999) Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: evidence for both genetic and environmental influences, Hepatology 30:476-484.
    • (1999) Hepatology , vol.30 , pp. 476-484
    • Ritter, J.K.1    Kessler, F.K.2    Thompson, M.T.3    Grove, A.D.4    Auyeung, D.J.5    Fisher, R.A.6
  • 82
    • 0030050983 scopus 로고    scopus 로고
    • Microtubular distribution prolongs the expression of human bilirubin-uridinediphosphoglucuronate-glucuronosyltransferase-1 gene transferred into Gunn rat livers
    • Roy Chowdhury N, Hays RM, Bommineni VR, Franki N, Roy Chowdhury J, Wu CH, and Wu GY (1996) Microtubular distribution prolongs the expression of human bilirubin-uridinediphosphoglucuronate-glucuronosyltransferase-1 gene transferred into Gunn rat livers. J Biol Chem 271:2341-2346.
    • (1996) J Biol Chem , vol.271 , pp. 2341-2346
    • Roy Chowdhury, N.1    Hays, R.M.2    Bommineni, V.R.3    Franki, N.4    Roy Chowdhury, J.5    Wu, C.H.6    Wu, G.Y.7
  • 84
    • 0002942277 scopus 로고    scopus 로고
    • Hereditary jaundice and disorders of bilirubin metabolism
    • (Scriver CR, Boudet AL, Sly W, Valle D, Childs B, Kinzler K, and Vogelstein B, eds), McGraw-Hill, New York
    • Roy Chowdhury J, Wolkoff AW, Roy Chowdhury N, and Arias IM (2001) Hereditary jaundice and disorders of bilirubin metabolism, in The Metabolic and Molecular Basis of Inherited Disease, 8th ed (Scriver CR, Boudet AL, Sly W, Valle D, Childs B, Kinzler K, and Vogelstein B, eds) pp 3063-3101, McGraw-Hill, New York.
    • (2001) The Metabolic and Molecular Basis of Inherited Disease, 8th Ed. , pp. 3063-3101
    • Roy Chowdhury, J.1    Wolkoff, A.W.2    Roy Chowdhury, N.3    Arias, I.M.4
  • 86
    • 0027991904 scopus 로고
    • Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation
    • Senafi SB, Clarke DJ, and Burchell B (1994) Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem J 303:233-240.
    • (1994) Biochem J , vol.303 , pp. 233-240
    • Senafi, S.B.1    Clarke, D.J.2    Burchell, B.3
  • 87
    • 0031756678 scopus 로고    scopus 로고
    • Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium
    • Strassburg CP, Nguyen N, Manns MP, and Tukey RH (1998) Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol 54:647-654.
    • (1998) Mol Pharmacol , vol.54 , pp. 647-654
    • Strassburg, C.P.1    Nguyen, N.2    Manns, M.P.3    Tukey, R.H.4
  • 88
    • 0036101804 scopus 로고    scopus 로고
    • Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
    • Strassburg CP, Vogel A, Kneip S, Tukey RH, and Manns MP (2002) Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut 50:851-856.
    • (2002) Gut , vol.50 , pp. 851-856
    • Strassburg, C.P.1    Vogel, A.2    Kneip, S.3    Tukey, R.H.4    Manns, M.P.5
  • 91
    • 0029970829 scopus 로고    scopus 로고
    • Long-term correction of bilirubin UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period
    • Takahashi M, Ilan Y, Roy Chowdhury N, Guida J, Horwitz MS, and Roy Chowdhury J (1996) Long-term correction of bilirubin UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period. J Biol Chem 271: 26536-26542.
    • (1996) J Biol Chem , vol.271 , pp. 26536-26542
    • Takahashi, M.1    Ilan, Y.2    Roy Chowdhury, N.3    Guida, J.4    Horwitz, M.S.5    Roy Chowdhury, J.6
  • 92
    • 0036052121 scopus 로고    scopus 로고
    • A non-immunogenic adenoviral vector, coexpressing CTLA41g and bilirubin-uridinediphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome
    • Thummala NR, Ghosh SS, Lee SW, Reddy B, Davidson A, Horwitz MS, Roy Chowdhury J, and Roy Chowdhury N (2002) A non-immunogenic adenoviral vector, coexpressing CTLA41g and bilirubin-uridinediphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome. Gene Ther 9:981-990.
    • (2002) Gene Ther , vol.9 , pp. 981-990
    • Thummala, N.R.1    Ghosh, S.S.2    Lee, S.W.3    Reddy, B.4    Davidson, A.5    Horwitz, M.S.6    Roy Chowdhury, J.7    Roy Chowdhury, N.8
  • 93
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression and disease
    • Tukey RH and Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression and disease. Annu Rev Pharmacol Toxicol 40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 94
    • 0034695410 scopus 로고    scopus 로고
    • Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4
    • Turgeon D, Carrier JS, Levesque E, Beatty BG, Belanger A, and Hum DW (2000) Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. J Mol Biol 295:489-504.
    • (2000) J Mol Biol , vol.295 , pp. 489-504
    • Turgeon, D.1    Carrier, J.S.2    Levesque, E.3    Beatty, B.G.4    Belanger, A.5    Hum, D.W.6
  • 95
    • 0023187951 scopus 로고
    • Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome
    • Ullrich D, Sieg A, Blume R, Bock KW, Schroter W, and Bircher J (1987) Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome. Eur J Clin Investig 17:237-240.
    • (1987) Eur J Clin Investig , vol.17 , pp. 237-240
    • Ullrich, D.1    Sieg, A.2    Blume, R.3    Bock, K.W.4    Schroter, W.5    Bircher, J.6
  • 96
    • 0028956177 scopus 로고
    • Potential genoprotective role for UDP-glucuronosyltransferases (UGTs) in chemical carcinogenesis: Initiation of micronuclei by benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts
    • Vienneau DS, DeBoni U, and Wells PG (1995) Potential genoprotective role for UDP-glucuronosyltransferases (UGTs) in chemical carcinogenesis: initiation of micronuclei by benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts. Cancer Res 55:1045-1051.
    • (1995) Cancer Res , vol.55 , pp. 1045-1051
    • Vienneau, D.S.1    DeBoni, U.2    Wells, P.G.3
  • 97
    • 0141519502 scopus 로고    scopus 로고
    • Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs
    • Villeneuve L, Girard H, Fortier LC, and Guillemette C (2003) Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther 307:117-128.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 117-128
    • Villeneuve, L.1    Girard, H.2    Fortier, L.C.3    Guillemette, C.4
  • 98
    • 0034765595 scopus 로고    scopus 로고
    • Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene
    • Vogel A, Kneip S, Barut A, Ehmer U, Tukey RH, Manns MP, and Strassburg CP (2001) Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Gastroenterology 121:1136-1144.
    • (2001) Gastroenterology , vol.121 , pp. 1136-1144
    • Vogel, A.1    Kneip, S.2    Barut, A.3    Ehmer, U.4    Tukey, R.H.5    Manns, M.P.6    Strassburg, C.P.7
  • 100
    • 0000628714 scopus 로고
    • Benzo(a)pyrene embryopathy in rats genetically deficient in bilirubin UDP-glucuronyl transferase
    • Wells PG, Obilo FC, and de Morais SMF (1989) Benzo(a)pyrene embryopathy in rats genetically deficient in bilirubin UDP-glucuronyl transferase. FASEB J 3:A1025.
    • (1989) FASEB J , vol.3
    • Wells, P.G.1    Obilo, F.C.2    De Morais, S.M.F.3
  • 101
    • 0029968112 scopus 로고    scopus 로고
    • Biochemical toxicology of chemical teratogenesis
    • Wells PG and Winn LM (1996) Biochemical toxicology of chemical teratogenesis. Crit Rev Biochem Mol Biol 31:1-40.
    • (1996) Crit Rev Biochem Mol Biol , vol.31 , pp. 1-40
    • Wells, P.G.1    Winn, L.M.2
  • 103
    • 0035913673 scopus 로고    scopus 로고
    • Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk
    • Zheng Z, Park JY, Guillemette C, Schantz SP, and Lazarus P (2001) Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. J Natl Cancer Inst 93:1411-1418.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1411-1418
    • Zheng, Z.1    Park, J.Y.2    Guillemette, C.3    Schantz, S.P.4    Lazarus, P.5


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