Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

Journal of Biological Chemistry

Volumn 279, Issue 30, 2004, Pages 31556-31567

  McMahon, Michael ^a   Thomas, Nerys ^a   Itoh, Ken ^b   Yamamoto, Masayuki ^b   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; OXIDATION; REDOX REACTIONS; SENSITIVITY ANALYSIS; SEPARATION; STRESSES;

CELL GROWTH; HEMEOSTATIC CONDITIONS; KELCH-REPEAT PROTEINS; REDOX-REGULATED TURNOVER;

PROTEINS;

ASPARTYLISOLEUCYLASPARTYLLEUCYLISOLEUCYLASPARTIC ACID; CELL PROTEIN; GLUTAMYLTHREONYLGLYCYLGLUTAMIC ACID; HYBRID PROTEIN; KELCH REPEAT PROTEIN; PROTEIN KEAP1; TETRAPEPTIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DELETION MUTANT; HOMEOSTASIS; NEH2 DEGRON; NEH6 DEGRON; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN MOTIF; REDUCTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; COS CELLS; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; HALF-LIFE; HOMEOSTASIS; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS;

ANIMALIA;

EID: 3843104763     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403061200     Document Type: Article

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