Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721

Protein Science

Volumn 20, Issue 10, 2011, Pages 1713-1719

  Cheng, Yuan ^a,b   Redinbo, Matthew R ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c University of North Carolina at Chapel Hill   (United States)

Author keywords

Anti HIV drug; Human nuclear xenobiotic receptor; PNU 142721; PXR; Reverse transcriptase

Indexed keywords

6 CHLORO 2 [(1 FURO[2,3 C]PYRIDIN 5 YLETHYL)THIO] 4 PYRIMIDINAMINE; ANTIVIRUS AGENT; PNU 173575; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HIV REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PYRIDINES; PYRIMIDINES; RATS; RECEPTORS, STEROID;

HUMAN IMMUNODEFICIENCY VIRUS; RATTUS;

EID: 80053165065     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.706     Document Type: Article

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