Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

Drug Metabolism and Disposition

Volumn 37, Issue 8, 2009, Pages 1611-1621

  Cheng, Jie ^a   Ma, Xiaochao ^b   Krausz, Kristopher W ^a   Idle, Jeffrey R ^c   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 3A4; DRUG METABOLITE; HYDROGEN PEROXIDE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PREGNANE X RECEPTOR; PYRUVIC ACID DERIVATIVE; RIFAMPICIN; S (5 ACETYLAMINO 2 HYDROXYPHENYL)MERCAPTOPYRUVIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENTIATION; DRUG SAFETY; ENZYME INDUCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER INJURY; LIVER METABOLISM; LIVER NECROSIS; LIVER TOXICITY; MALE; METABOLOMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RNA ANALYSIS; TRANSGENIC MOUSE; URINALYSIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-BACTERIAL AGENTS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CYSTEINE; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ENZYME INDUCTION; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; LIVER; LIVER DISEASES; LYSOPHOSPHATIDYLCHOLINES; MALE; METABOLOMICS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NECROSIS; OXIDATIVE STRESS; PRINCIPAL COMPONENT ANALYSIS; RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER; TIME FACTORS;

MUS;

EID: 67650831245     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027565     Document Type: Article

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