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Biochemistry (Moscow)

Volumn 76, Issue 10, 2011, Pages 1087-1097

Constitutive androstane receptor (CAR) is a xenosensor and target for therapy

(4) Kachaylo, E M a,b Pustylnyak, V O a,b Lyakhovich, V V a,b Gulyaeva, L F a,b

a INSTITUTE OF MOLECULAR BIOLOGY AND BIOPHYSICS (Russian Federation)

b NOVOSIBIRSK STATE UNIVERSITY (Russian Federation)

Author keywords

CAR; gene expression activation; ligands; metabolism; xenobiotics

Indexed keywords

EID: 80054732029 PISSN: 00062979 EISSN: 16083040 Source Type: Journal
DOI: 10.1134/S0006297911100026 Document Type: Review

Times cited : (32)

References (74)

1
- 0033574663
- Committee Nuclear Receptors Nomenclature. 10.1016/S0092-8674(00)80726-6
- Committee Nuclear Receptors Nomenclature 1999 Cell 97 161 163 10.1016/S0092-8674(00)80726-6
- (1999) Cell , vol.97 , pp. 161-163

2
- 37349114118
- Nuclear receptors: Decoding metabolic disease
- DOI 10.1016/j.febslet.2007.11.016, PII S001457930701160X
- J. Sonoda L. Pei R. Evans 2008 FEBS Lett. 582 2 9 18023286 10.1016/j.febslet.2007.11.016 1:CAS:528:DC%2BD2sXhsVOltb3N (Pubitemid 350297241)
- (2008) FEBS Letters , vol.582 , Issue.1 , pp. 2-9
- Sonoda, J.¹ Pei, L.² Evans, R.M.³

3
- 0034687397
- 11057673 10.1038/35038112 1:CAS:528:DC%2BD3cXns1Oks7s%3D
- P. Wei J. Zhang M. Egan-Hafley S. Liang D. Moore 2000 Nature 407 920 923 11057673 10.1038/35038112 1:CAS:528:DC%2BD3cXns1Oks7s%3D
- (2000) Nature , vol.407 , pp. 920-923
- Wei, P.¹ Zhang, J.² Egan-Hafley, M.³ Liang, S.⁴ Moore, D.⁵

4
- 0036142429
- Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
- DOI 10.1124/mol.61.1.1
- A. Ueda H. K. Hamadeh H. K. Webb Y. Yamamoto T. Sueyoshi C. A. Afshari J. M. Lehmann M. Negishi 2002 Mol. Pharmacol. 61 1 6 11752199 10.1124/mol.61.1.1 1:CAS:528:DC%2BD38Xlt12q (Pubitemid 34049505)
- (2002) Molecular Pharmacology , vol.61 , Issue.1 , pp. 1-6
- Ueda, A.¹ Hamadeh, H.K.² Webb, H.K.³ Yamamoto, Y.⁴ Sueyoshi, T.⁵ Afshari, C.A.⁶ Lehmann, J.M.⁷ Negishi, M.⁸

5
- 0034635529
- The peroxisome proliferator response element of the gene encoding the peroxisomal β-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor β/9-cis- retinoic acid receptor-mediated transactivation
- DOI 10.1074/jbc.275.6.4345
- A. Kassam C. J. Winrow F. Fernandez-Rachubinski J. P. Capone R. A. Rachubinski 2000 J. Biol. Chem. 275 4345 4350 10660604 10.1074/jbc.275.6.4345 1:CAS:528:DC%2BD3cXht12gur0%3D (Pubitemid 30094676)
- (2000) Journal of Biological Chemistry , vol.275 , Issue.6 , pp. 4345-4350
- Kassam, A.¹ Winrow, C.J.² Fernandez-Rachubinski, F.³ Capone, J.P.⁴ Rachubinski, R.A.⁵

6
- 18444399926
- Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia
- DOI 10.1006/bbrc.2002.6683
- J. Sugatani K. Yamakawa K. Yoshinari T. Machida H. Takagi M. Mori S. Kakizaki T. Sueyoshi M. Negishi M. Miwa 2002 Biochem. Biophys. Res. Commun. 292 492 497 11906189 10.1006/bbrc.2002.6683 1:CAS:528:DC%2BD38XitFeitLs%3D (Pubitemid 34694291)
- (2002) Biochemical and Biophysical Research Communications , vol.292 , Issue.2 , pp. 492-497
- Sugatani, J.¹ Yamakawa, K.² Yoshinari, K.³ Machida, T.⁴ Takagi, H.⁵ Mori, M.⁶ Kakizaki, S.⁷ Sueyoshi, T.⁸ Negishi, M.⁹ Miwa, M.¹⁰

7
- 9944247695
- Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
- DOI 10.1016/j.abb.2004.09.019, PII S000398610400534X
- J. J. Eloranta G. A. Kullak-Ublick 2005 Arch. Biochem. Biophys. 433 397 412 15581596 10.1016/j.abb.2004.09.019 1:CAS:528:DC%2BD2cXhtVCgtLrL (Pubitemid 39592794)
- (2005) Archives of Biochemistry and Biophysics , vol.433 , Issue.2 , pp. 397-412
- Eloranta, J.J.¹ Kullak-Ublick, G.A.²

8
- 0028210426
- 8114692 1:CAS:528:DyaK2cXis1ais7Y%3D
- M. Baes T. Gulick H. S. Choi M. G. Martinoli D. Simha D. D. Moore 1994 Mol. Cell. Biol. 14 1544 1552 8114692 1:CAS:528:DyaK2cXis1ais7Y%3D
- (1994) Mol. Cell. Biol. , vol.14 , pp. 1544-1552
- Baes, M.¹ Gulick, T.² Choi, H.S.³ Martinoli, M.G.⁴ Simha, D.⁵ Moore, D.D.⁶

9
- 0032497544
- Androstane metabolites bind to and deactivate the nuclear receptor CAR- β
- DOI 10.1038/26996
- B. M. Forman I. Tzameli H. S. Choi J. Chen D. Simha W. Seol R. M. Evans D. D. Moore 1998 Nature 395 612 615 9783588 10.1038/26996 1:CAS:528: DyaK1cXms1ejsr4%3D (Pubitemid 28475716)
- (1998) Nature , vol.395 , Issue.6702 , pp. 612-615
- Forman, B.M.¹ Tzameli, I.² Choi, H.-S.³ Chen, J.⁴ Simha, D.⁵ Seol, W.⁶ Evans, R.M.⁷ Moore, D.D.⁸

10
- 33847024555
- CAR and PXR: The xenobiotic-sensing receptors
- DOI 10.1016/j.steroids.2006.12.006, PII S0039128X06002649
- Y. E. Timsit M. Negishi 2007 Steroids 72 231 246 17284330 10.1016/j.steroids.2006.12.006 1:CAS:528:DC%2BD2sXitFOks7g%3D (Pubitemid 46273513)
- (2007) Steroids , vol.72 , Issue.3 , pp. 231-246
- Timsit, Y.E.¹ Negishi, M.²

11
- 34547288177
- Induction of cytochrome P4502B: Role of regulatory elements and nuclear receptors
- DOI 10.1134/S000629790706003X
- V. O. Pustylnyak L. F. Gulyaeva V. V. Lyakhovich 2007 Biochemistry (Moscow) 72 608 617 10.1134/S000629790706003X 1:CAS:528:DC%2BD2sXntFGqu7c%3D (Pubitemid 47142360)
- (2007) Biochemistry (Moscow) , vol.72 , Issue.6 , pp. 608-617
- Pustylnyak, V.O.¹ Gulyaeva, L.F.² Lyakhovich, V.V.³

12
- 34249705919
- Difference in nucleocytoplasmic shuttling sequences of rat and human constitutive active/androstane receptor
- DOI 10.1016/j.bbamcr.2007.03.020, PII S0167488907000808
- Y. Kanno M. Suzuki Y. Miyazaki M. Matsuzaki T. Nakahama K. Kurose J. Sawada Y. Inouye 2007 Biochim. Biophys. Acta 1773 934 944 17488649 10.1016/j.bbamcr.2007.03.020 1:CAS:528:DC%2BD2sXmtVansbY%3D (Pubitemid 46829445)
- (2007) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1773 , Issue.6 , pp. 934-944
- Kanno, Y.¹ Suzuki, M.² Miyazaki, Y.³ Matsuzaki, M.⁴ Nakahama, T.⁵ Kurose, K.⁶ Sawada, J.-i.⁷ Inouye, Y.⁸

13
- 0036756840
- Nuclear receptors: Nomenclature, ligands, mechanisms of their effects on gene expression
- DOI 10.1023/A:1020545200302
- A. N. Smirnov 2002 Biochemistry (Moscow) 67 957 977 10.1023/A: 1020545200302 1:CAS:528:DC%2BD38Xns12htr0%3D (Pubitemid 35361716)
- (2002) Biochemistry (Moscow) , vol.67 , Issue.9 , pp. 957-977
- Smirnov, A.N.¹

14
- 33645877393
- 10.1507/endocrj.53.157 1:CAS:528:DC%2BD28XmsFyqsb8%3D
- M. Kishimoto R. Fujiki S. Takezawa Y. Sassaki T. Nakamura K. Yamaoka H. Kitagawa S. Kato 2006 Endocrine J. 53 157 172 10.1507/endocrj.53.157 1:CAS:528:DC%2BD28XmsFyqsb8%3D
- (2006) Endocrine J. , vol.53 , pp. 157-172
- Kishimoto, M.¹ Fujiki, R.² Takezawa, S.³ Sassaki, Y.⁴ Nakamura, T.⁵ Yamaoka, K.⁶ Kitagawa, H.⁷ Kato, S.⁸

15
- 77949911622
- 20113149 10.1517/17425251003598886 1:CAS:528:DC%2BC3cXjsFeitLs%3D
- H. Li H. Wang 2010 Expert. Opin. Drug. Metab. Toxicol. 6 409 426 20113149 10.1517/17425251003598886 1:CAS:528:DC%2BC3cXjsFeitLs%3D
- (2010) Expert. Opin. Drug. Metab. Toxicol. , vol.6 , pp. 409-426
- Li, H.¹ Wang, H.²

16
- 19944372389
- A structural basis for constitutive activity in the human CAR/RXRα heterodimer
- DOI 10.1016/j.molcel.2004.11.042, PII S1097276504007579
- R. X. Xu M. H. Lambert B. B. Wisely E. N. Warren E. E. Weinert G. M. Waitt J. D. Williams J. L. Collins L. B. Moore T. M. Willson J. T. Moore 2004 Mol. Cell 16 919 928 15610735 10.1016/j.molcel.2004.11.042 1:CAS:528: DC%2BD2MXjvVWjsw%3D%3D (Pubitemid 40018402)
- (2004) Molecular Cell , vol.16 , Issue.6 , pp. 919-928
- Xu, R.X.¹ Lambert, M.H.² Wisely, B.B.³ Warren, E.N.⁴ Weinert, E.E.⁵ Waitt, G.M.⁶ Williams, J.D.⁷ Collins, J.L.⁸ Moore, L.B.⁹ Willson, T.M.¹⁰ Moore, J.T.¹¹

17
- 28844433794
- A. Aranda A. Pascual 2001 Physiol. Rev. 81 1270 1304
- (2001) Physiol. Rev. , vol.81 , pp. 1270-1304
- Aranda, A.¹ Pascual, A.²

18
- 78651256360
- 21220114 10.1016/j.str.2010.11.008 1:CAS:528:DC%2BC3MXksFCrsw%3D%3D
- E. Wright S. A. Busby S. Wisecarver J. Vincent P. R. Griffin E. J. Fernandez 2011 Structure 19 37 44 21220114 10.1016/j.str.2010.11.008 1:CAS:528:DC%2BC3MXksFCrsw%3D%3D
- (2011) Structure , vol.19 , pp. 37-44
- Wright, E.¹ Busby, S.A.² Wisecarver, S.³ Vincent, J.⁴ Griffin, P.R.⁵ Fernandez, E.J.⁶

19
- 0031682988
- 9742082 1:CAS:528:DyaK1cXmsVKltbg%3D
- P. Honkakoski I. Zelko T. Sueyoshi M. Negishi 1998 Mol. Cell. Biol. 18 5652 5658 9742082 1:CAS:528:DyaK1cXmsVKltbg%3D
- (1998) Mol. Cell. Biol. , vol.18 , pp. 5652-5658
- Honkakoski, P.¹ Zelko, I.² Sueyoshi, T.³ Negishi, M.⁴

20
- 23044436687
- CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
- DOI 10.1002/hep.20784
- M. Wagner E. Halilbasic H. U. Marschall G. Zollner P. Fickert C. Langner K. Zatloukal H. Denk M. Trauner 2005 Hepatology 42 420 430 15986414 10.1002/hep.20784 1:CAS:528:DC%2BD2MXpt1eksbs%3D (Pubitemid 41061095)
- (2005) Hepatology , vol.42 , Issue.2 , pp. 420-430
- Wagner, M.¹ Halilbasic, E.² Marschall, H.-U.³ Zollner, G.⁴ Fickert, P.⁵ Langner, C.⁶ Zatloukal, K.⁷ Denk, H.⁸ Trauner, M.⁹

21
- 41149143719
- PPP1R16A, the membrane subunit of protein phosphatase 1β, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor
- DOI 10.1124/mol.107.042960
- T. Sueyoshi R. Moore J. Sugatani Y. Matsumura M. Negishi 2008 Mol. Pharmacol. 73 1113 1121 18202305 10.1124/mol.107.042960 1:CAS:528: DC%2BD1cXjvFemu7c%3D (Pubitemid 351439193)
- (2008) Molecular Pharmacology , vol.73 , Issue.4 , pp. 1113-1121
- Sueyoshi, T.¹ Moore, R.² Sugatani, J.³ Matsumura, Y.⁴ Negishi, M.⁵

22
- 0037563788
- Alternatively spliced isoforms of the human constitutive androstane receptor
- DOI 10.1093/nar/gkg419
- S. S. Auerbach R. Ramsden M. A. Stoner C. Verlinde C. Hassett C. J. Omiecinski 2003 Nucleic Acids Res. 31 3194 3207 12799447 10.1093/nar/gkg419 1:CAS:528:DC%2BD3sXks1Wqt7k%3D (Pubitemid 37441779)
- (2003) Nucleic Acids Research , vol.31 , Issue.12 , pp. 3194-3207
- Auerbach, S.S.¹ Ramsden, R.² Stoner, M.A.³ Verlinde, C.⁴ Hassett, C.⁵ Omiecinski, C.J.⁶

23
- 0034649218
- 11027630 10.1006/bbrc.2000.3557 1:CAS:528:DC%2BD3cXntFOqt7c%3D
- I. Zelko M. Negishi 2000 Biochem. Biophys. Res. Commun. 277 1 6 11027630 10.1006/bbrc.2000.3557 1:CAS:528:DC%2BD3cXntFOqt7c%3D
- (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 1-6
- Zelko, I.¹ Negishi, M.²

24
- 0037515661
- A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
- DOI 10.1074/jbc.M212482200
- H. Wang S. Faucette T. Sueyoshi R. Moore S. Ferguson M. Negishi E. LeCluyse 2003 J. Biol. Chem. 278 14146 14152 12571232 10.1074/jbc.M212482200 1:CAS:528:DC%2BD3sXjtVShsr4%3D (Pubitemid 36799961)
- (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 14146-14152
- Wang, H.¹ Faucette, S.² Sueyoshi, T.³ Moore, R.⁴ Ferguson, S.⁵ Negishi, M.⁶ LeCluyse, E.L.⁷

25
- 33646536088
- 16724929 10.2174/138920006776873508 1:CAS:528:DC%2BD28XmvV2mt7c%3D
- H. Yamada Y. Ishii M. Yamamoto K. Oguri 2006 Curr. Drug Metab. 7 397 409 16724929 10.2174/138920006776873508 1:CAS:528:DC%2BD28XmvV2mt7c%3D
- (2006) Curr. Drug Metab. , vol.7 , pp. 397-409
- Yamada, H.¹ Ishii, Y.² Yamamoto, M.³ Oguri, K.⁴

26
- 3142764845
- Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin
- DOI 10.1074/jbc.M400580200
- H. Wang S. Faucette R. Moore T. Sueyoshi M. Negishi E. LeCluyse 2004 J. Biol. Chem. 279 29295 29301 15123723 10.1074/jbc.M400580200 1:CAS:528: DC%2BD2cXlsVCmsbk%3D (Pubitemid 38915806)
- (2004) Journal of Biological Chemistry , vol.279 , Issue.28 , pp. 29295-29301
- Wang, H.¹ Faucette, S.² Moore, R.³ Sueyoshi, T.⁴ Negishi, M.⁵ LeCluyse, E.⁶

27
- 0035310906
- Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1
- DOI 10.1042/0264-6021:3550071
- R. Muangmoonchai D. Smirlis S. C. Wong M. Edwards I. R. Phillips E. A. Shephard 2001 Biochem. J. 355 71 78 11256950 10.1042/0264-6021:3550071 1:CAS:528:DC%2BD3MXjtVOktb8%3D (Pubitemid 32304236)
- (2001) Biochemical Journal , vol.355 , Issue.1 , pp. 71-78
- Muangmoonchai, R.¹ Smirlis, D.² Wong, S.-C.³ Edwards, M.⁴ Phillips, I.R.⁵ Shephard, E.A.⁶

28
- 0037135532
- Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo
- DOI 10.1074/jbc.M200051200
- G. Min J. K. Kemper B. Kemper 2002 J. Biol. Chem. 277 26356 26363 12000748 10.1074/jbc.M200051200 1:CAS:528:DC%2BD38XlsFKrtbY%3D (Pubitemid 34967128)
- (2002) Journal of Biological Chemistry , vol.277 , Issue.29 , pp. 26356-26363
- Min, G.¹ Kim Kemper, J.² Kemper, B.³

29
- 0038514189
- Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor γ coactivator-1α: A possible link between xenobiotic response and nutritional state
- DOI 10.1074/jbc.M212859200
- T. Shiraki N. Sakai E. Kanaya H. Jingami 2003 J. Biol. Chem. 278 11344 11350 12551939 10.1074/jbc.M212859200 1:CAS:528:DC%2BD3sXit1Kgtr0%3D (Pubitemid 36792692)
- (2003) Journal of Biological Chemistry , vol.278 , Issue.13 , pp. 11344-11350
- Shiraki, T.¹ Sakai, N.² Kanaya, E.³ Jingami, H.⁴

30
- 67651176090
- 19429690 10.1093/nar/gkp333 1:CAS:528:DC%2BD1MXovVektrc%3D
- Y. B. Xie B. Nedumaran H. S. Choi 2009 Nucleic Acids Res. 37 4100 4115 19429690 10.1093/nar/gkp333 1:CAS:528:DC%2BD1MXovVektrc%3D
- (2009) Nucleic Acids Res. , vol.37 , pp. 4100-4115
- Xie, Y.B.¹ Nedumaran, B.² Choi, H.S.³

31
- 23944443096
- Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR
- DOI 10.1016/j.bbamcr.2005.06.012, PII S0167488905001461
- Y. Kanno M. Suzuki T. Nakahama Y. Inouye 2005 Biochim. Biophys. Acta 1745 215 222 16055207 10.1016/j.bbamcr.2005.06.012 1:CAS:528:DC%2BD2MXpslCgt7Y%3D (Pubitemid 41207894)
- (2005) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1745 , Issue.2 , pp. 215-222
- Kanno, Y.¹ Suzuki, M.² Nakahama, T.³ Inouye, Y.⁴

32
- 0037450418
- 12573483 1:CAS:528:DC%2BD3sXovFGrsA%3D%3D
- S. Kakizaki M. Yamamoto A. Ueda 2003 Biochim. Biophys. Acta 1619 239 242 12573483 1:CAS:528:DC%2BD3sXovFGrsA%3D%3D
- (2003) Biochim. Biophys. Acta , vol.1619 , pp. 239-242
- Kakizaki, S.¹ Yamamoto, M.² Ueda, A.³

33
- 0033999734
- The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
- DOI 10.1128/MCB.20.9.2951-2958.2000
- I. Tzameli P. Pissios E. G. Schuetz D. D. Moore 2000 Mol. Cell Biol. 20 2951 2958 10757780 10.1128/MCB.20.9.2951-2958.2000 1:CAS:528: DC%2BD3cXivFSksb0%3D (Pubitemid 30215008)
- (2000) Molecular and Cellular Biology , vol.20 , Issue.9 , pp. 2951-2958
- Tzameli, I.¹ Pissios, P.² Schuetz, E.G.³ Moore, D.D.⁴

34
- 0037931737
- Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
- DOI 10.1074/jbc.M300138200
- J. M. Maglich D. J. Parks L. B. Moore J. L. Collins B. Goodwin A. N. Billin C. A. Stoltz S. A. Kliewer M. H. Lambert T. M. Willson J. T. Moore 2003 J. Biol. Chem. 278 17277 17283 12611900 10.1074/jbc.M300138200 1:CAS:528:DC%2BD3sXjsVKms7Y%3D (Pubitemid 36799610)
- (2003) Journal of Biological Chemistry , vol.278 , Issue.19 , pp. 17277-17283
- Maglich, J.M.¹ Parks, D.J.² Moore, L.B.³ Collins, J.L.⁴ Goodwin, B.⁵ Billin, A.N.⁶ Stoltz, C.A.⁷ Kliewer, S.A.⁸ Lambert, M.H.⁹ Willson, T.M.¹⁰ Moore, J.T.¹¹

35
- 70649113044
- 19895823 10.1016/j.lfs.2009.10.015 1:CAS:528:DC%2BD1MXhsV2msrzL
- V. Pustylnyak E. Pivovarova N. Slynko L. Gulyaeva V. Lyakhovich 2009 Life Sci. 85 815 821 19895823 10.1016/j.lfs.2009.10.015 1:CAS:528:DC%2BD1MXhsV2msrzL
- (2009) Life Sci. , vol.85 , pp. 815-821
- Pustylnyak, V.¹ Pivovarova, E.² Slynko, N.³ Gulyaeva, L.⁴ Lyakhovich, V.⁵

36
- 33845660439
- Comparative study of CYP2B induction in the liver of rats and mice by different compounds
- DOI 10.1016/j.lfs.2006.09.015, PII S0024320506007338
- V. O. Pustylnyak A. N. Lebedev L. F. Gulyaeva V. V. Lyakhovich N. M. Slynko 2007 Life Sci. 80 324 328 17045615 10.1016/j.lfs.2006.09.015 1:CAS:528:DC%2BD2sXht1Ghsg%3D%3D (Pubitemid 44958713)
- (2007) Life Sciences , vol.80 , Issue.4 , pp. 324-328
- Pustylnyak, V.O.¹ Lebedev, A.N.² Gulyaeva, L.F.³ Lyakhovich, V.V.⁴ Slynko, N.M.⁵

37
- 0025191963
- 1:CAS:528:DyaK3cXhslWltLg%3D
- V. M. Mishin N. I. Gutkina V. V. Lyakhovich L. N. Pospelova V. V. Chistyakov 1990 Biokhimiya 55 29 36 1:CAS:528:DyaK3cXhslWltLg%3D
- (1990) Biokhimiya , vol.55 , pp. 29-36
- Mishin, V.M.¹ Gutkina, N.I.² Lyakhovich, V.V.³ Pospelova, L.N.⁴ Chistyakov, V.V.⁵

38
- 14044269562
- Amino acids important for ligand specificity of the human constitutive androstane receptor
- DOI 10.1074/jbc.M411241200
- J. Jyrkkarinne B. Windshugel J. Makinen M. Ylisirnio M. Perakyla A. Poso W. Sippl P. Honkakoski 2005 J. Biol. Chem. 280 5960 5971 15572376 10.1074/jbc.M411241200 (Pubitemid 40280080)
- (2005) Journal of Biological Chemistry , vol.280 , Issue.7 , pp. 5960-5971
- Jyrkkarinne, J.¹ Windshugel, B.² Makinen, J.³ Ylisirnio, M.⁴ Perakyla, M.⁵ Poso, A.⁶ Sippl, W.⁷ Honkakoski, P.⁸

39
- 0034685779
- Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
- DOI 10.1074/jbc.M001215200
- L. B. Moore D. J. Parks S. A. Jones R. K. Bledsoe T. G. Consler J. B. Stimmel B. Goodwin C. Liddle S. G. Blanchard T. M. Willson J. L. Collins S. A. Kliewer 2000 J. Biol. Chem. 275 15122 15127 10748001 10.1074/jbc.M001215200 1:CAS:528:DC%2BD3cXjsFanuro%3D (Pubitemid 30337234)
- (2000) Journal of Biological Chemistry , vol.275 , Issue.20 , pp. 15122-15127
- Moore, L.B.¹ Parks, D.J.² Jones, S.A.³ Bledsoe, R.K.⁴ Consler, T.G.⁵ Stimmel, J.B.⁶ Goodwin, B.⁷ Liddle, C.⁸ Blanchard, S.G.⁹ Willson, T.M.¹⁰ Collins, J.L.¹¹ Kliewer, S.A.¹²

40
- 0042236405
- Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
- DOI 10.1016/S0014-5793(03)00720-8
- K. Yoshinari K. Kobayashi R. Moore T. Kawamoto M. Negishi 2003 FEBS Lett. 548 17 20 12885400 10.1016/S0014-5793(03)00720-8 1:CAS:528:DC%2BD3sXls1Ontro%3D (Pubitemid 37281243)
- (2003) FEBS Letters , vol.548 , Issue.1-3 , pp. 17-20
- Yoshinari, K.¹ Kobayashi, K.² Moore, R.³ Kawamoto, T.⁴ Negishi, M.⁵

41
- 33645109954
- 16377764 10.1124/mol.105.019505 1:CAS:528:DC%2BD28XjtlKntrs%3D
- F. Hosseinpour R. Moore M. Negishi T. Sueyoshi 2006 Mol. Pharmacol. 69 1095 1102 16377764 10.1124/mol.105.019505 1:CAS:528:DC%2BD28XjtlKntrs%3D
- (2006) Mol. Pharmacol. , vol.69 , pp. 1095-1102
- Hosseinpour, F.¹ Moore, R.² Negishi, M.³ Sueyoshi, T.⁴

42
- 71749090253
- 19858220 10.1074/jbc.M109.048108 1:CAS:528:DC%2BD1MXhsFWitb7M
- S. Mutoh M. Osabe K. Inoue R. Moore L. Pedersen L. Perera Y. Rebolloso T. Sueyoshi M. Negishi 2009 J. Biol. Chem. 284 34785 34792 19858220 10.1074/jbc.M109.048108 1:CAS:528:DC%2BD1MXhsFWitb7M
- (2009) J. Biol. Chem. , vol.284 , pp. 34785-34792
- Mutoh, S.¹ Osabe, M.² Inoue, K.³ Moore, R.⁴ Pedersen, L.⁵ Perera, L.⁶ Rebolloso, Y.⁷ Sueyoshi, T.⁸ Negishi, M.⁹

43
- 9144231188
- A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification
- DOI 10.1124/mol.65.2.292
- S. P. Saini J. Sonoda L. Xu D. Toma H. Uppal Y. Mu S. Ren D. D. Moore R. M. Evans W. Xie 2004 Mol. Pharmacol. 65 292 300 14742670 10.1124/mol.65.2.292 1:CAS:528:DC%2BD2cXitFaksr0%3D (Pubitemid 38134256)
- (2004) Molecular Pharmacology , vol.65 , Issue.2 , pp. 292-300
- Saini, S.P.S.¹ Sonoda, J.² Xu, L.³ Toma, D.⁴ Uppal, H.⁵ Mu, Y.⁶ Ren, S.⁷ Moore, D.D.⁸ Evans, R.M.⁹ Xie, W.¹⁰

44
- 0345731376
- Regulation of Drug and Bile Salt Transporters in Liver and Intestine
- DOI 10.1081/DMR-120026398
- G. A. Kullak-Ublick M. B. Becker 2003 Drug Metab. Rev. 35 305 317 14705863 10.1081/DMR-120026398 1:CAS:528:DC%2BD3sXps1ygs7g%3D (Pubitemid 38018109)
- (2003) Drug Metabolism Reviews , vol.35 , Issue.4 , pp. 305-317
- Kullak-Ublick, G.A.¹ Becker, M.-B.²

45
- 41349121332
- 18328680 10.1016/j.ejps.2008.01.008 1:CAS:528:DC%2BD1cXktlGjsrs%3D
- P. Olinga M. G. Elferink A. L. Draaisma M. T. Merema J. V. Castell G. Perez G. M. Groothuis 2008 Eur. J. Pharm. Sci. 33 380 389 18328680 10.1016/j.ejps.2008.01.008 1:CAS:528:DC%2BD1cXktlGjsrs%3D
- (2008) Eur. J. Pharm. Sci. , vol.33 , pp. 380-389
- Olinga, P.¹ Elferink, M.G.² Draaisma, A.L.³ Merema, M.T.⁴ Castell, J.V.⁵ Perez, G.⁶ Groothuis, G.M.⁷

46
- 0242288522
- Dietary Effects on Drug Metabolism and Transport
- DOI 10.2165/00003088-200342130-00001
- R. Z. Harris G. R. Jang S. Tsunoda 2003 Clin. Pharmacokinet. 42 1071 1088 14531721 10.2165/00003088-200342130-00001 1:CAS:528:DC%2BD3sXpsF2ls70%3D (Pubitemid 37357646)
- (2003) Clinical Pharmacokinetics , vol.42 , Issue.13 , pp. 1071-1088
- Harris, R.Z.¹ Jang, G.R.² Tsunoda, S.³

47
- 0034892970
- Acute liver failure
- DOI 10.1097/00004836-200109000-00005
- R. Q. Gill R. K. Sterling 2001 J. Clin. Gastroenterol. 33 191 198 11500606 10.1097/00004836-200109000-00005 1:STN:280:DC%2BD3MvlsFShtA%3D%3D (Pubitemid 32762887)
- (2001) Journal of Clinical Gastroenterology , vol.33 , Issue.3 , pp. 191-198
- Gill, R.Q.¹ Sterling, R.K.²

48
- 0016769104
- 171822 1:CAS:528:DyaE28XmvFWhtw%3D%3D
- F. Schaffner 1975 Vet. Pathol. 12 145 156 171822 1:CAS:528: DyaE28XmvFWhtw%3D%3D
- (1975) Vet. Pathol. , vol.12 , pp. 145-156
- Schaffner, F.¹

49
- 0030990138
- Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses
- DOI 10.1021/tx960159i
- L. K. Rogers B. Moorthy C. V. Smith 1997 Chem. Res. Toxicol. 10 470 476 9114986 10.1021/tx960159i 1:CAS:528:DyaK2sXivVKmu78%3D (Pubitemid 27176311)
- (1997) Chemical Research in Toxicology , vol.10 , Issue.4 , pp. 470-476
- Rogers, L.K.¹ Moorthy, B.² Smith, C.V.³

50
- 0037064177
- Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
- DOI 10.1126/science.1073502
- J. Zhang W. Huang S. S. Chua P. Wei D. D. Moore 2002 Science 298 422 424 12376703 10.1126/science.1073502 1:CAS:528:DC%2BD38Xns12htbw%3D (Pubitemid 35176352)
- (2002) Science , vol.298 , Issue.5592 , pp. 422-424
- Zhang, J.¹ Huang, W.² Chua, S.S.³ Wei, P.⁴ Moore, D.D.⁵

51
- 33751568515
- Nuclear receptors CAR and PXR in the regulation of hepatic metabolism
- DOI 10.1080/00498250600861827, PII Q41067521857X895
- E. S. Tien M. Negishi 2006 Xenobiotica 36 1152 1163 17118922 10.1080/00498250600861827 1:CAS:528:DC%2BD28XhtlGqsLvM (Pubitemid 44844116)
- (2006) Xenobiotica , vol.36 , Issue.10-11 , pp. 1152-1163
- Tien, E.S.¹ Negishi, M.²

52
- 52449108842
- 18781913 10.2174/138920008785821666 1:CAS:528:DC%2BD1cXht1ynsbjJ
- S. Kakizaki Y. Yamazaki D. Takizawa M. Negishi 2008 Curr. Drug Metab. 9 614 621 18781913 10.2174/138920008785821666 1:CAS:528:DC%2BD1cXht1ynsbjJ
- (2008) Curr. Drug Metab. , vol.9 , pp. 614-621
- Kakizaki, S.¹ Yamazaki, Y.² Takizawa, D.³ Negishi, M.⁴

53
- 31544431796
- 1:CAS:528:DC%2BD28Xnt1GntQ%3D%3D
- M. Sutija J. M. Joss 2006 J. Comp. Physiol. 176 87 92 1:CAS:528:DC%2BD28Xnt1GntQ%3D%3D
- (2006) J. Comp. Physiol. , vol.176 , pp. 87-92
- Sutija, M.¹ Joss, J.M.²

54
- 33845905551
- The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver
- DOI 10.1124/jpet.106.112706
- E. S. Tien K. Matsui R. Moore M. Negishi 2007 J. Pharmacol. Exp. Ther. 320 307 313 17050775 10.1124/jpet.106.112706 1:CAS:528:DC%2BD2sXjsFCitA%3D%3D (Pubitemid 46025745)
- (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.1 , pp. 307-313
- Tien, E.S.¹ Matsui, K.² Moore, R.³ Negishi, M.⁴

55
- 47249085240
- Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor
- DOI 10.1021/bi800393u
- M. Jeyakumar P. Webb J. D. Baxter T. S. Scanlan J. A. Katzenellenbogen 2008 Biochemistry 47 7465 7476 18558711 10.1021/bi800393u 1:CAS:528: DC%2BD1cXntlaqsr8%3D (Pubitemid 351991025)
- (2008) Biochemistry , vol.47 , Issue.28 , pp. 7465-7476
- Jeyakumar, M.¹ Webb, P.² Baxter, J.D.³ Scanlan, T.S.⁴ Katzenellenbogen, J.A.⁵

56
- 14244270349
- Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism
- DOI 10.1210/en.2004-1350
- M. Qatanani J. Zhang D. D. Moore 2005 Endocrinology 146 995 1002 15564320 10.1210/en.2004-1350 1:CAS:528:DC%2BD2MXitlehs7Y%3D (Pubitemid 40289286)
- (2005) Endocrinology , vol.146 , Issue.3 , pp. 995-1002
- Qatanani, M.¹ Zhang, J.² Moore, D.D.³

57
- 0037072887
- 12114525 10.1074/jbc.M205239200 1:CAS:528:DC%2BD38Xnt1Witr4%3D
- G. Min H. Kim Y. Bae L. Petz J. K. Kemper 2002 J. Biol. Chem. 277 34626 34633 12114525 10.1074/jbc.M205239200 1:CAS:528:DC%2BD38Xnt1Witr4%3D
- (2002) J. Biol. Chem. , vol.277 , pp. 34626-34633
- Min, G.¹ Kim, H.² Bae, Y.³ Petz, L.⁴ Kemper, J.K.⁵

58
- 10944229118
- 15610734 1:CAS:528:DC%2BD2MXjvVWjsg%3D%3D
- L. Shan J. Vincent J. S. Brunzelle I. Dussault M. Lin I. Ianculescu M. A. Sherman B. M. Forman E. J. Fernandez 2004 Mol. Cell 16 907 917 15610734 1:CAS:528:DC%2BD2MXjvVWjsg%3D%3D
- (2004) Mol. Cell , vol.16 , pp. 907-917
- Shan, L.¹ Vincent, J.² Brunzelle, J.S.³ Dussault, I.⁴ Lin, M.⁵ Ianculescu, I.⁶ Sherman, M.A.⁷ Forman, B.M.⁸ Fernandez, E.J.⁹

59
- 0032775358
- Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms
- DOI 10.1046/j.1365-2826.1999.00371.x
- H. Rosenbrock C. E. Hagemeyer I. Singec R. Knoth B. Volk 1999 J. Neuroendocrinol. 11 597 604 10447797 10.1046/j.1365-2826.1999.00371.x 1:CAS:528:DyaK1MXltFCgtL0%3D (Pubitemid 29338675)
- (1999) Journal of Neuroendocrinology , vol.11 , Issue.8 , pp. 597-604
- Rosenbrock, H.¹ Hagemeyer, C.E.² Singec, I.³ Knoth, R.⁴ Volk, B.⁵

60
- 22344451423
- Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor
- DOI 10.1210/me.2004-0520
- W. Huang J. Zhang M. Washington J. Liu J. M. Parant G. Lozano D. D. Moore 2005 Mol. Endocrinol. 19 1646 1653 15831521 10.1210/me.2004-0520 1:CAS:528:DC%2BD2MXkslyqt7c%3D (Pubitemid 41002992)
- (2005) Molecular Endocrinology , vol.19 , Issue.6 , pp. 1646-1653
- Huang, W.¹ Zhang, J.² Washington, M.³ Liu, J.⁴ Parant, J.M.⁵ Lozano, G.⁶ Moore, D.D.⁷

61
- 5644295430
- The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
- DOI 10.1158/0008-5472.CAN-04-1459
- Y. Yamamoto R. Moore T. L. Goldsworthy M. Negishi R. R. Maronpot 2004 Cancer Res. 64 7197 7200 15492232 10.1158/0008-5472.CAN-04-1459 1:CAS:528:DC%2BD2cXosFyntr0%3D (Pubitemid 39372050)
- (2004) Cancer Research , vol.64 , Issue.20 , pp. 7197-7200
- Yamamoto, Y.¹ Moore, R.² Goldsworthy, T.L.³ Negishi, M.⁴ Maronpot, R.R.⁵

62
- 4644333017
- 15382178 1:CAS:528:DC%2BD2cXptV2qtbc%3D
- G. M. Ledda-Columbano M. Pibiri C. Cossu F. Molotzu J. Locker A. Columbano 2004 Hepatology 40 981 988 15382178 1:CAS:528:DC%2BD2cXptV2qtbc%3D
- (2004) Hepatology , vol.40 , pp. 981-988
- Ledda-Columbano, G.M.¹ Pibiri, M.² Cossu, C.³ Molotzu, F.⁴ Locker, J.⁵ Columbano, A.⁶

63
- 30944463481
- Gadd45β is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia
- DOI 10.1002/hep.20883
- A. Columbano G. M. Ledda-Columbano M. Pibiri C. Cossu M. Menegazzi D. D. Moore W. Huang J. Tian J. Locker 2005 Hepatology 42 1118 1126 16231353 10.1002/hep.20883 1:CAS:528:DC%2BD2MXht1amtbvP (Pubitemid 43112679)
- (2005) Hepatology , vol.42 , Issue.5 , pp. 1118-1126
- Columbano, A.¹ Ledda-Columbano, G.M.² Pibiri, M.³ Cossu, C.⁴ Menegazzi, M.⁵ Moore, D.D.⁶ Huang, W.⁷ Tian, J.⁸ Locker, J.⁹

64
- 3142670509
- A potent modifier of liver cancer risk on distal mouse chromosome 1: Linkage analysis and characterization of congenic lines
- DOI 10.1534/genetics.103.024521
- A. Bilger L. M. Bennett R. A. Carabeo T. A. Chiaverotti C. Dvorak K. M. Liss S. A. Schadewald H. C. Pitot N. R. Drinkwater 2004 Genetics 167 859 866 15238534 10.1534/genetics.103.024521 1:CAS:528:DC%2BD2cXms1KntbY%3D (Pubitemid 38931870)
- (2004) Genetics , vol.167 , Issue.2 , pp. 859-866
- Bilger, A.¹ Bennett, L.M.² Carabeo, R.A.³ Chiaverotti, T.A.⁴ Dvorak, C.⁵ Liss, K.M.⁶ Schadewald, S.A.⁷ Pitot, H.C.⁸ Drinkwater, N.R.⁹

65
- 0033673203
- 11118008 10.2337/diabetes.49.12.2063 1:CAS:528:DC%2BD3cXos1ejs7o%3D
- R. S. Hundal M. Krssak S. Dufour D. Laurent V. Lebon V. Chandramouli S. E. Inzucchi W. C. Schumann, et al. 2000 Diabetes 49 2063 2069 11118008 10.2337/diabetes.49.12.2063 1:CAS:528:DC%2BD3cXos1ejs7o%3D
- (2000) Diabetes , vol.49 , pp. 2063-2069
- Hundal, R.S.¹ Krssak, M.² Dufour, S.³ Laurent, D.⁴ Lebon, V.⁵ Chandramouli, V.⁶ Inzucchi, S.E.⁷ Schumann, W.C.⁸

66
- 0023584295
- Effects of phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene on differentiated functions in mouse liver
- DOI 10.1016/0009-2797(87)90062-7
- G. Manenti T. A. Dragani G. D. Porta 1987 Chem. Biol. Interact. 64 83 92 2446787 10.1016/0009-2797(87)90062-7 1:CAS:528:DyaL1cXhtVOru7c%3D (Pubitemid 18016861)
- (1987) Chemico-Biological Interactions , vol.64 , Issue.1-2 , pp. 83-92
- Manenti, G.¹ Dragani, T.A.² Della Porta, G.³

67
- 0026347037
- 1764030 1:CAS:528:DyaK3MXmslSnt7o%3D
- D. Argaud S. Halimi F. Catelloni X. M. Leverve 1991 Biochem. J. 280 663 669 1764030 1:CAS:528:DyaK3MXmslSnt7o%3D
- (1991) Biochem. J. , vol.280 , pp. 663-669
- Argaud, D.¹ Halimi, S.² Catelloni, F.³ Leverve, X.M.⁴

68
- 0035185021
- 11696581 1:CAS:528:DC%2BD3MXot12ktLY%3D
- J. Nakae T. Kitamura D. L. Silver D. Accili 2001 J. Clin. Invest. 108 1359 1367 11696581 1:CAS:528:DC%2BD3MXot12ktLY%3D
- (2001) J. Clin. Invest. , vol.108 , pp. 1359-1367
- Nakae, J.¹ Kitamura, T.² Silver, D.L.³ Accili, D.⁴

69
- 4444246000
- Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
- DOI 10.1128/MCB.24.18.7931-7940.2004
- S. Kodama C. Koike M. Negishi Y. Yamamoto 2004 Mol. Cell. Biol. 24 7931 7940 15340055 10.1128/MCB.24.18.7931-7940.2004 1:CAS:528:DC%2BD2cXnslCrs7o%3D (Pubitemid 39167443)
- (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 7931-7940
- Kodama, S.¹ Koike, C.² Negishi, M.³ Yamamoto, Y.⁴

70
- 70350031574
- 19617349 10.1074/jbc.M109.016808 1:CAS:528:DC%2BD1MXhtFWhtrzE
- J. Gao J. He Y. Zhai T. Wada W. Xie 2009 J. Biol. Chem. 284 25984 25992 19617349 10.1074/jbc.M109.016808 1:CAS:528:DC%2BD1MXhtFWhtrzE
- (2009) J. Biol. Chem. , vol.284 , pp. 25984-25992
- Gao, J.¹ He, J.² Zhai, Y.³ Wada, T.⁴ Xie, W.⁵

71
- 73249140987
- 19850873 10.1073/pnas.0909731106 1:CAS:528:DC%2BD1MXhsVKmsLrL
- B. Dong P. K. Saha W. Huang W. Chen L. A. Abu-Elheiga S. J. Wakil R. D. Stevens O. Ilkayeva C. B. Newgard L. Chan D. D. Moore 2009 Proc. Natl. Acad. Sci. USA 106 18831 18836 19850873 10.1073/pnas.0909731106 1:CAS:528: DC%2BD1MXhsVKmsLrL
- (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 18831-18836
- Dong, B.¹ Saha, P.K.² Huang, W.³ Chen, W.⁴ Abu-Elheiga, L.A.⁵ Wakil, S.J.⁶ Stevens, R.D.⁷ Ilkayeva, O.⁸ Newgard, C.B.⁹ Chan, L.¹⁰ Moore, D.D.¹¹

72
- 33744962967
- Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α
- DOI 10.1074/jbc.M510713200
- J. Miao S. Fang Y. Bae J. K. Kemper 2006 J. Biol. Chem. 281 14537 14546 16492670 10.1074/jbc.M510713200 1:CAS:528:DC%2BD28XkslGqsro%3D (Pubitemid 43855156)
- (2006) Journal of Biological Chemistry , vol.281 , Issue.21 , pp. 14537-14546
- Miao, J.¹ Fang, S.² Bae, Y.³ Kemper, J.K.⁴

73
- 42249111748
- 18305370 10.2133/dmpk.23.8 1:CAS:528:DC%2BD1cXkvFegtrk%3D
- Y. Konno M. Negishi S. Kodama 2008 Drug Metab. Pharmacokinet. 23 8 13 18305370 10.2133/dmpk.23.8 1:CAS:528:DC%2BD1cXkvFegtrk%3D
- (2008) Drug Metab. Pharmacokinet. , vol.23 , pp. 8-13
- Konno, Y.¹ Negishi, M.² Kodama, S.³

74
- 78649576502
- 20736325 10.1124/dmd.110.035568 1:CAS:528:DC%2BC3cXhsFGgurjO
- J. Gao W. Xie 2010 Drug Metab. Dispos. 38 2091 2095 20736325 10.1124/dmd.110.035568 1:CAS:528:DC%2BC3cXhsFGgurjO
- (2010) Drug Metab. Dispos. , vol.38 , pp. 2091-2095
- Gao, J.¹ Xie, W.²

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