LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor

Science

Volumn 325, Issue 5936, 2009, Pages 100-104

  Zelcer, Noam ^a,b,c   Hong, Cynthia ^a,b   Boyadjian, Rima ^a,b   Tontonoz, Peter ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE DEGRADER OF THE LDLR; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

CYTOLOGY; CYTOPLASM; FAT; LIPID; PLASMA; PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOPLASM; DEGRADATION; HOMEOSTASIS; IN VIVO STUDY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TISSUE; TRANSCRIPTION INITIATION; UBIQUITINATION;

ANIMALS; CELL LINE, TUMOR; CHOLESTEROL; DNA-BINDING PROTEINS; HOMEOSTASIS; HUMANS; LIGANDS; LIPOPROTEINS, LDL; LIVER; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LDL; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

ADENOVIRIDAE;

EID: 67650092919     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1168974     Document Type: Article

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33. We thank members of the Tontonoz and Edwards laboratories and J. Wohlschlegel, P. Edwards, and S. G. Young for fruitful discussions. We thank P. Tarr for assistance with confocal microscopy, K. Matter and A. Gonzalez for LDLR plasmids, and I. Koster for critically reading the manuscript. N.Z. was supported by a long-term postdoctoral fellowship from the Human Frontier Science Program Organization. P.T. is an investigator of the Howard Hughes Medical Institute. This work was also supported by NIH grants HL066088, HL090553, and HL030568. UCLA and two of the authors (N.Z. and P.T.) have filed a patent related to this work.