Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

Advanced Drug Delivery Reviews

Volumn 62, Issue 13, 2010, Pages 1238-1249

  Tolson, Antonia H ^a   Wang, Hongbing ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

CAR; Drug metabolizing enzyme; PXR; Transporter; Xenobiotic receptor

Indexed keywords

CAR; DRUG-METABOLIZING ENZYMES; PXR; TRANSPORTER; XENOBIOTIC RECEPTOR;

CATALYSTS; DETOXIFICATION; ENZYMES; GENES; LIGANDS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

BIOACTIVITY;

ALDO KETO REDUCTASE; AROMATIC HYDROCARBON RECEPTOR; CARBOXYLESTERASE; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; DEXAMETHASONE; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A6; GLUTATHIONE; GLUTATHIONE TRANSFERASE A1; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; PHENOBARBITAL; PREGNANE X RECEPTOR; SULFOTRANSFERASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

DRUG DISPOSITION; DRUG GLUCURONIDATION; DRUG SULFATION; DRUG TRANSFORMATION; GENE CONTROL; HUMAN; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVIEW; UPREGULATION; XENOBIOTIC METABOLISM;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; METABOLIC DETOXICATION, DRUG; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 78650175257     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2010.08.006     Document Type: Review

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