PXR, car and drug metabolism

Nature Reviews Drug Discovery

Volumn 1, Issue 4, 2002, Pages 259-266

  Willson, Timothy M ^a   Kliewer, Steven A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANDROSTANE DERIVATIVE; ANTIFUNGAL AGENT; CLOTRIMAZOLE; CYTOCHROME P450; CYTOCHROME P450 3A4; DEXAMETHASONE; DOCETAXEL; GEMFIBROZIL; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; HERBACEOUS AGENT; HORMONE RECEPTOR; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; LITHOCHOLIC ACID; MACROLIDE; MULTIDRUG RESISTANCE PROTEIN; OXYGENASE; PACLITAXEL; PHENOBARBITAL; PIOGLITAZONE; PREGNANE X RECEPTOR; RIFAMPICIN; RITONAVIR; ROSIGLITAZONE; TROGLITAZONE; UNINDEXED DRUG; XENOBIOTIC AGENT; ZOXAZOLAMINE; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A; N DEMETHYLASE; S MEPHENYTOIN N DEMETHYLASE; S-MEPHENYTOIN N-DEMETHYLASE; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNSPECIFIC MONOOXYGENASE;

AEROBIC METABOLISM; BINDING AFFINITY; DRUG CROSS REACTIVITY; DRUG DETERMINATION; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; HUMAN; LIVER TOXICITY; MOUSE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; OXIDOREDUCTASES, N-DEMETHYLATING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 0036528233     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd753     Document Type: Review

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