Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

Biochemical Pharmacology

Volumn 79, Issue 2, 2010, Pages 261-269

  Yoshinari, Kouichi ^a   Yoda, Noriaki ^a   Toriyabe, Takayoshi ^a   Yamazoe, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Aryl hydrocarbon receptor; CYP induction; HepG2 cell; In vitro reporter assay; Nuclear receptor

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; GENE PRODUCT; MESSENGER RNA; PROTEIN ER8; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; GENE ACTIVATION; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; RECEPTOR BINDING; REGULATORY SEQUENCE; REPORTER GENE; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DIMERIZATION; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, REPORTER; HEPATOCYTES; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 71749119309     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.08.008     Document Type: Article

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