Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes.

Drug metabolism and pharmacokinetics

Volumn 22, Issue 3, 2007, Pages 178-186

  Nishimura, Masuhiro ^a   Koeda, Akiko ^a   Suganuma, Yasuyuki ^a   Suzuki, Emako ^a   Shimizu, Takefumi ^a   Nakayama, Mitsuo ^a   Satoh, Tetsuo ^a   Narimatsu, Shizuo ^a   Naito, Shinsaku ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYP3A1 PROTEIN, RAT; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A; DEXAMETHASONE; MESSENGER RNA; OMEPRAZOLE; RIFAMPICIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ADULT; AGED; ANIMAL; ARTICLE; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER CELL; MACACA; MALE; METABOLISM; PRESCHOOL CHILD; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ADULT; AGED; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CHILD, PRESCHOOL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; MACACA FASCICULARIS; MALE; OMEPRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFAMPIN; RNA, MESSENGER;

EID: 34548532926     PISSN: 13474367     EISSN: None     Source Type: Journal    
DOI: 10.2133/dmpk.22.178     Document Type: Article

References (0)