Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor

Drug Metabolism and Disposition

Volumn 37, Issue 9, 2009, Pages 1887-1894

  Tolson, Antonia H ^a   Li, Haishan ^a   Eddington, Natalie D ^a   Wang, Hongbing ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE 1A1; LIVER ENZYME; MESSENGER RNA; METHADONE; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; RIFAMPICIN; YELLOW FLUORESCENT PROTEIN;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; ENANTIOMER; ENZYME INDUCTION; ENZYME METABOLISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; LIVER CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; STEREOCHEMISTRY; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE; ENZYME INDUCTION; HEPATOCYTES; HUMANS; INDICATORS AND REAGENTS; LIVER; METHADONE; MIXED FUNCTION OXYGENASES; NARCOTICS; PHARMACEUTICAL PREPARATIONS; PLASMIDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 70349091103     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027854     Document Type: Article

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