Orphan nuclear receptors - The first eight years

Molecular Endocrinology

Volumn 10, Issue 11, 1996, Pages 1293-1307

  Enmark, Eva ^a   Gustafsson, Jan Åke ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL RECEPTOR; CELL NUCLEUS RECEPTOR; ECDYSONE; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; PROGESTERONE RECEPTOR; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; CELL NUCLEUS; DNA BINDING; HORMONE RECEPTOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CLONING, MOLECULAR; DNA; DRUG DESIGN; EVOLUTION; FORECASTING; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 0030462820     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.11.1293     Document Type: Review

References (155)

1. 1 transactivation domain. Mutat Res 333:15-22
2. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
3. Forman BM, Samuels HH 1990 Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol Endocrinol 4:1293-1301
4. Laudet V, Hanni C, Coll J, Catzeflis F, Stehelin D 1992 Evolution of the nuclear receptor gene superfamily. EMBO J 11:1003-1013
5. Barettino D, Vivanco RM, Stunnenberg HG 1994 Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J 13:3039-3049
6. Giguere V, Yang N, Segui P, Evans RM 1988 Identification of a new class of steroid hormone receptors. Nature 331:91-94
7. Sutherland JD, Kozlova T, Tzertzinis G, Kafatos FC 1995 Drosophila hormone receptor 38: a second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type. Proc Natl Acad Sci USA 92:7966-7970
8. Perlmann T, Jansson L 1995 A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev 9:769-782
9. Yu RT, McKeown M, Evans RM, Umesono K 1994 Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor TIx. Nature 370:375-379
10. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, Fitzhugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. 1996 Disruption of the nuclear hormone receptor ROR-alpha in staggerer mice. Nature 379:736-739
11. Kostrouch Z, Kostrouchova M, Rail JE 1995 Steroid/ thyroid hormone receptor genes in Caenorhabditis elegans. Proc Natl Acad Sci USA 92:156-159
12. Speulman E, Salamini F 1995 A barley cdna clone with homology to the DNA-binding domain of the steroid hormone receptors. Plant Sci 106:91-98
13. Kuiper GJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-Å 1995 Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA, in press
14. Keller H, Givel F, Perroud M, Wahli W 1995 Signaling cross-talk between peroxisome proliferator activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol Endocrinol 9:794-804
15. Zanaria E, Muscatelli F, Bardoni B, Strom TM, Guioli S, Guo W, Lalli E, Moser C, Walker AP, McCabe ERB, Meitinger T, Monaco AP, Sassone-Corsi P, Camerino G. 1994 An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372:635-641
16. Sengupta P, Colbert HA, Bargmann CI 1994 The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily. Cell 79:971-980
17. Muscatelli F, Strom TM, Walker AP, Zanaria E, Recan D, Meindl A, Bardoni B, Guioli S, Zehetner G, Rabl W, Schwarz HP, Kaplan J-C, Camerino G, Meitinger T, Monaco AP 1994 Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 372:672-676
18. Seol W, Choi H, Moore D 1996 An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272:1336-1339
19. Segraves WA, Hogness DS 1990 The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. Genes Dev 4:204-219
20. Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR 1992 The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol Endocrinol 6:3-7
21. Rothe M, Nauber U, Jackle H 1989 Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger. EMBO J 8:3087-3094
22. Teboul M, Enmark E, Li Q, Wikström AC, Pelto-Huikko M, Gustafsson J-Å 1995 OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc Natl Acad Sci USA 92:2096-2100
23. Chen F, Cooney AJ, Wang Y, Law SW, O'Malley BW 1994 Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol Endocrinol 8:1434-1444
24. Issemann I, Green S 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650
25. Lala DS, Rice DA, Parker KL 1992 Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol Endocrinol 6:1249-1258
26. Chang C, Lopez da Silva S, Ideta R, Lee Y, Yeh S, Burbach JP 1994 Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci USA 91:6040-6044
27. Law SW, Conneely OM, DeMayo FJ, O'Malley BW 1992 Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol 6:2129-2135
28. Becker-Andre M, Andre E, DeLamarter JF 1993 Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochem Biophys Res Commun 194:1371-1379
29. Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW 1989 COUP transcription factor is a member of the steroid receptor superfamily. Nature 340:163-166
30. Seol W, Choi HS, Moore DD 1995 Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol 9:72-85
31. Sladek FM, Zhong WM, Lai E, Darnell JJ 1990 Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 4:2353-2365
32. Ryseck RP, Macdonald BH, Mattei MG, Ruppert S, Bravo R 1989 Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J 8:3327-3335
33. McClelland M, Mathieu DF, Welsh J 1995 RNA finger-printing and differential display using arbitrarily primed PCR. Trends Genet 11:242-246
34. Nauber U, Pankratz MJ, Kienlin A, Seifert E, Klemm U, Jackle H 1988 Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps. Nature 336:489-492
35. Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, Bonfield J, Burton J, Connell M, Copsey T, Cooper F, Coulson A, Craxton M, Dear S, Du Z, Durbin R, Favello A, Fraser A, Fulton L, Gardner A, Green P, Hawkins T, Hillier L, Jier M, Johnston L, Jones M, Kershaw J, Kirsten J, Laisster N, Latreille P, Lightning F, Lloyd C, Mortimore B, O'Callaghan M, Parsons F, Perry C, Rifken L, Roopra A, Saunders D, Shownkeen R, Sims M, Smaldon N, Smith A, Smith M, Sonnhammer E, Staden R, Sulston F, Thierry-Mieg F, Thomas K, Vandin M, Vaughan K, Waterston R, Watson A, Weinstock L, Wilkinson-Sproat J 1994 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368:32-38
36. Umesono K, Evans RM 1989 Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146
37. Zilliacus J, Carlstedt DJ, Gustafsson J-Å, Wright AP 1994 Evolution of distinct DNA-binding specificities within the nuclear receptor family of transcription factors. Proc Natl Acad Sci USA 91:4175-4179
38. Umesono K, Murakami KK, Thompson CC, Evans RM 1991 Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255-66
39. Wilson TE, Fahrner TJ, Milbrandt J 1993 The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 13:5794-5804
40. Harding H, Lazar M 1993 The orphan receptor Rev-ErbAa activates transcription via a novel response element. Mol Cell Biol 13:3113-3121
41. McBroom LD, Flock G, Giguere V 1995 The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions. Mol Cell Biol 15:796-808
42. 3 signalling. Nature 355:446-449
43. Jiang G, Nepomuceno L, Hopkins K, Sladek FM 1995 Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol Cell Biol 15:5131-5143
44. Harding HP, Lazar MA 1995 The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol Cell Biol 15:4791-4802
45. Glass CK 1994 Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr Rev 15:391-407
46. Bakke M, Lund J 1995 Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3′,5′-monophosphate-responsive sequence in the bovine CYP17 gene. Mol Endocrinol 9:327-339
47. Legraverend C, Eguchi H, Ström A, Lahuna O, Mode A, Tollet P, Westin S, Gustafsson J-Å 1994 Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily. Biochemistry 33:9889-9897
48. Tautz D 1992 Redundancies, development and the flow of information. Bioessays 14:263-266
49. Jones BB, Ohno CK, Allenby G, Boffa MB, Levin AA, Grippo JF, Petkovich M 1995 New retinoid x receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid. Mol Cell Biol 15:5226-5234
50. Giguere V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G 1994 Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Genes Dev 8:538-553
51. Morohashi K, Iida H, Nomura M, Hatano O, Honda S, Tsukiyama T, Niwa O, Hara T, et al. 1994 Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Mol Endocrinol 8:643-653
52. Cooney AJ, Leng X, Tsai SY, O'Malley BW, Tsai MJ 1993 Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. J Biol Chem 268:4152-4160
53. Forman BM, Chen J, Blumberg B, Kliewer SA, Henshaw R, Ong ES, Evans RM 1994 Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol 8:1253-1261
54. Song C, Kokontis JM, Hiipakka RA, Liao S 1994 Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc Natl Acad Sci USA 91:10809-10813
55. Segraves WA 1994 Steroid receptors and orphan receptors in Drosophila development. Semin Cell Biol 5:105-113
56. Pignoni F, Baldarelli RM, Steingrimsson E, Diaz RJ, Patapoutian A, Merriam JR, Lengyel JA 1990 The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor super-family. Cell 62:151-163
57. Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen WH, Nachtigal MW, Abbud R, Nilson JH, Parker KL 1994 The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev 8:2302-12
58. Lavorgna G, Ueda H, Clos J, Wu C 1991 FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu. Science 252:848-851
59. Milbrandt J 1988 Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1:183-188
60. Becker-Andre M, Wiesenberg I, Schaeren WN, Andre E, Missbach M, Saurat JH, Carlberg C 1994 Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 269: 28531-28534
61. Allen JB, Walberg MW, Edwards MC, Elledge SJ 1995 Finding prospective partners in the library - the two-hybrid system and phage display find a match. Trends Biochem Sci 20:511-516
62. Schulman IG, Chakravarti D, Juguilon H, Romo A, Evans RM 1995 Interactions between the retinoid x receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation. Proc Natl Acad Sci USA 92:8288-8292
63. Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW 1992 Members of the steroid hormone receptor superfamily interact with TFIIB(S300-II). J Biol Chem 267:17617-17623
64. Cavailles V, Dauvois S, Lhorset F, Lopez G, Hoare S, Kushner PJ, Parker MG 1995 A nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J 14:3741-3751
65. Chen JD, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
66. Halachmi S, Marden E, Martin G, MacKay I, Abbondanza C, Brown M 1994 Estrogen receptor-associated proteins: possible mediators of hormone induced transcription. Science 264:1455-1458
67. Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan K, Kamei Y, et al. 1995 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404
68. Thummel CS 1995 From embryogenesis to metamorphosis: the regulation an function of Drosophila nuclear receptor superfamily members. Cell 83:871-877
69. Kastner P, Mark M, Chambon P 1995 Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83:859-869
70. Beato M, Herrlich P, Schutz G 1995 Steroid hormone receptors: many actors in search of a plot. Cell 83: 851-857
71. Mangelsdorf DJ, Evans RM 1995 The RXR heterodimers and orphan receptors. Cell 83:841-850
72. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM 1995 The nuclear receptor superfamily: the second decade. Cell 83:835-839
73. Davis IJ, Lau LF 1994 Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol Cell Biol 14:3469-3483
74. Moore DD 1990 Diversity and unity in the nuclear hormone receptors: a terpenoid receptor superfamily. New Biol 2:100-105
75. Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, et al. 1995 Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81:687-93
76. Smith JR, Osborne TF, Brown MS, Goldstein JL, Gil G 1988 Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Biol Chem 263:18480-18487
77. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM 1995 15-deoxy-delta(12, 14)-prostaglandin j(2) is a ligand for the adipocyte determination factor ppar-gamma. Cell 83:803-812
78. Guarnieri C, Flamigni F, Caldarera CM 1980 A possible role of rabbit heart cytosol tocopherol binding in the transfer of tocopherol into nuclei. Biochem J 190:469-471
79. Lemotte PK, Keidel S, Apfel CM 1996 Phytanic acid is a retinoid X receptor ligand. Eur J Biochem 236:328-333
80. O'Malley BW, Conneely OM 1992 Orphan receptors: in search of a unifying hypothesis for activation. Mol Endocrinol 6:1359-1361
81. Safe SH 1995 Environmental and dietary estrogens and human health: is there a problem? Environ Health Perspect 103:346-351
82. Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM 1990 Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345:224-229
83. Zeng Z, Allan GF, Thaller C, Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ 1994 Detection of potential ligands for nuclear receptors in cellular extracts. Endocrinology 135:248-252
84. Banner CD, Göttlicher M, Widmark E, Sjövall J, Rafter JJ, Gustafsson J-A 1993 A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma. J Lipid Res 34:1583-1591
85. Mak P, McDonnell DP, Weigel NL, Schrader WT, O'Malley BW 1989 Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). J Biol Chem 264:21613-21618
86. Göttlicher M, Widmark E, Li Q, Gustafsson J-Å 1992 Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci USA 89:4653-4657
87. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM 1995 A prostaglandin j(2) metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-819
88. Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF, Darnell JJ 1994 Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8:2466-2477
89. Crawford PA, Sadovsky Y, Woodson K, Lee SL, Milbrandt J 1995 Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol 15:4331-4316
90. Petterson K, Svensson K, Matsson R, Carlsson B, Ohlsson R, Berkenstam A 1996 Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev 54: 211-223
91. Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF, Darnell JJ 1994 Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci USA 91:7598-7602
92. O'Malley B 1990 The steroid receptor superfamily: more excitement predicted for the future. Mol Endocrinol 4:363-369
93. Gish W, States DJ 1993 Identification of protein coding regions by database similarity search. Nat Genet 3:266-272
94. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T 1988 Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res 16:11057-11074
95. Jonk LJ, de JM, Pals CE, Wissink S, Vervaart JM, Schoorlemmer J, Kruijer W 1994 Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors. Mech Dev 47:81-97
96. Wehrenberg U, Ivell R, Walther N 1992 The COUP transcription factor (COUP-TF) is directly involved in the regulation of oxytocin gene expression in luteinizing bovine granulosa cells. Biochem Biophys Res Commun 189:496-503
97. Lutz B, Kuratani S, Cooney AJ, Wawersik S, Tsai SY, Eichele G, Tsai MJ 1994 Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons. Development 120:25-36
98. Matharu PJ, Sweeney GE 1992 Cloning and sequencing of a COUP transcription factor gene expressed in Xenopus embryos. Biochim Biophys Acta 1129:331-334
99. Chan SM, Xu N, Niemeyer CC, Bone JR, Flytzanis CN 1992 SpCOUP-TF: a sea urchin member of the steroid/ thyroid hormone receptor family. Proc Natl Acad Sci USA 89:10568-10572
100. Fjose A, Nornes S, Weber U, Mlodzik M 1993 Functional conservation of vertebrate seven-up related genes in neurogenesis and eye development. EMBO J 12:1403-14
101. Ladias JA, Karathanasis SK 1991 Regulation of the apolipoprotein Al gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251:561-565
102. Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ 1991 The COUP-TFs compose a family of functionally related transcription factors. Gene Expression 1:207-216
103. Mlodzik M, Hiromi Y, Weber U, Goodman CS, Rubin GM 1990 The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60:211-224
104. Hazel TG, Nathans D, Lau LF 1988 A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci USA 85:8444-8448
105. Nakai A, Kartha S, Sakurai A, Toback FG, DeGroot LJ 1990 A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol Endocrinol 4:1438-1443
106. Chang C, Kokontis J, Liao SS, Chang Y 1989 Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. J Steroid Biochem 34:391-395
107. Mages HW, Rilke O, Bravo R, Senger G, Kroczek RA 1994 NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. Mol Endocrinol 8:1583-1591
108. Okabe T, Takayanagi R, Imasaki K, Haji M, Nawata H, Watanabe T 1995 cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. J Immunol 154:3871-3879
109. Deleted in proof
110. Scearce LM, Laz TM, Hazel TG, Lau LF, Taub R 1993 RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J Biol Chem 268:8855-8861
111. Lopes da Silva S, van Horssen A, Chang C, Burbach JP 1995 Expression of nuclear hormone receptors in the rat supraoptic nucleus. Endocrinology 136:2276-2283
112. Ohkura N, Hijikuro M, Yamamoto A, Miki K 1994 Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem Biophys Res Commun 205:1959-1965
113. Smith TS, Matharu PJ, Sweeney GE 1993 Cloning and sequencing of a Xenopus homologue of the inducible orphan receptor NGFI-B. Biochim Biophys Acta 1173:239-242
114. Tsukiyama T, Ueda H, Hirose S, Niwa O 1992 Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily. Mol Cell Biol 12:1286-1291
115. Honda S, Morohashi K, Nomura M, Takeya H, Kitajima M, Omura T 1993 Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. J Biol Chem 268:7494-7502
116. Nomura M, Bartsch S, Nawata H, Omura T, Morohashi K 1995 An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development. J Biol Chem 270:7453-7461
117. Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP, Parker KL 1993 Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860
118. Deleted in proof
119. Ellinger ZH, Hihi AK, Laudet V, Keller H, Wahli W, Dreyer C 1994 FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis. Mol Cell Biol 14:2786-2797
120. Sun GC, Hirose S, Ueda H 1994 Intermittent expression of BmFTZ-F1, a member of the nuclear hormone receptor superfamily during development of the silkworm Bombyx mori. Dev Biol 162:426-437
121. Ayer S, Walker N, Mosammaparast M, Nelson JP, Shilo BZ, Benyajati C 1993 Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element. Nucleic Acids Res 21:1619-1627
122. Deleted in proof
123. Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, Becker-Andre M 1994 RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol Endocrinol 8:757-770
124. Hirose T, Smith RJ, Jetten AM 1994 ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem Biophys Res Commun 205:1976-1983
125. Koelle MR, Segraves WA, Hogness DS 1992 DHR3: a Drosophila steroid receptor homolog. Proc Natl Acad Sci USA 89:6167-6171
126. Jindra M, Sehnal F, Riddiford LM 1994 Isolation, characterization and developmental expression of the ecdysteroid-induced E75 gene of the wax moth Galleria mellonella. Eur J Biochem 221:665-675
127. Palli SR, Hiruma K, Riddiford LM 1992 An ecdysteroid-inducible Manduca gene similar to the Drosophila DHR3 gene, a member of the steroid hormone receptor superfamily. Dev Biol 150:306-318
128. Lazar MA, Hodin RA, Darling DS, Chin WW 1989 A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol 9:1128-1136
129. Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, Yamamoto T 1989 Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57:31-39
130. Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD 1994 A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. Mol Endocrinol 8:996-1005
131. Retnakaran R, Flock G, Giguere V 1994 Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol 8:1234-1244
132. Enmark E, Kainu T, Pelto-Huikko M, Gustafsson J-Å 1994 Identification of a novel member of the nuclear receptor superfamily which is closely related to Rev-ErbA. Biochem Biophys Res Commun 204:49-56
133. Bonnelye E, Vanacker JM, Desbiens X, Begue A, Stehelin D, Laudet V 1994 Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development. Cell Growth Differ 5:1357-1365
134. Deleted in proof
135. Feigl G, Gram M, Pongs O 1989 A member of the steroid hormone receptor gene family is expressed in the 20-OH-ecdysone inducible puff 75B in Drosophila melanogaster. Nucleic Acids Res 17:7167-7178
136. Segraves WA, Woldin C 1993 The E75 gene of Manduca sexta and comparison with its Drosophila homolog. Insect Biochem Mol Biol 23:91-97
137. Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A 1994 NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene 147:273-276
138. Apfel R, Benbrook D, Lernhardt E, Ortiz MA, Salbert G, Pfahl M 1994 A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol 14:7025-7035
139. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ 1995 LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9:1033-1045
140. Sommer R, Tautz D 1991 Segmentation gene expression in the housefly Musca domestica. Development 113:419-430
141. Oro AE, Ong ES, Margolis JS, Posakony JW, McKeown M, Evans RM 1988 The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Nature 336:493-496
142. Chang C, Kokontis J 1988 Identification of a new member of the steroid receptor super-family by cloning and sequence analysis. Biochem Biophys Res Commun 155:971-977
143. Chang C, Kokontis J, Acakpo SL, Liao S, Takeda H, Chang Y 1989 Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. Biochem Biophys Res Commun 165:735-741
144. Law SW, Conneely OM, O'Malley BW 1994 Molecular cloning of a novel member of the nuclear receptor superfamily related to the orphan receptor, TR2. Gene Expression 4:77-84
145. Zelhof AC, Yao T-P, Evans RM, McKeown M 1995 Identification and characterisation of a Drosophila nuclear receptor with the ability to inhibit the ecdysone receptor. Proc Natl Acad Sci USA 92:10477-10481
146. Fisk GJ, Thummel CS 1995 Isolation, regulation, and DNA-binding properties of three Drosophila nuclear hormone receptor superfamily members. Proc Natl Acad Sci USA 92:10604-10608
147. Hirose T, Fujimoto W, Tamaai T, Kim KH, Matsuura H, Jetten AM 1994 TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol Endocrinol 8:1667-1680
148. Deleted in proof
149. Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B 1994 Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver. Gene 147:269-272
150. Taraviras S, Monaghan AP, Schutz G, Kelsey G 1994 Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech Dev 48: 67-79
151. Zhong W, Sladek FM, Darnell JJ 1993 The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. EMBO J 12:537-544
152. Hirose T, O'Brien DA, Jetten AM 1995 RTR: a new member of the nuclear receptor superfamily that is highly expressed in murine testis. Gene 152:247-251
153. Smith DP, Mason CS, Jones EA, Old RW 1994 A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor. Nucleic Acids Res 22:66-71
154. Baes M, Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD 1994 A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14:1544-1551
155. Stone BL, Thummel CS 1993 The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily. Cell 75:307-320