-
1
-
-
24644447094
-
Drug-induced oxidative stress in rat liver from a toxicogenomics perspective
-
Mcmillian M, Nie A, Parker JB, Leone A, Kemmerer M, Bryant S, Herlich J, Yieh L, Bittner A, Liu X, Wan J, Johnson MD, Lord P. Drug-induced oxidative stress in rat liver from a toxicogenomics perspective. Toxicol Appl Pharmocol 2005;207(2 Suppl):171-178.
-
(2005)
Toxicol Appl Pharmocol
, vol.207
, Issue.2 SUPPL.
, pp. 171-178
-
-
McMillian, M.1
Nie, A.2
Parker, J.B.3
Leone, A.4
Kemmerer, M.5
Bryant, S.6
Herlich, J.7
Yieh, L.8
Bittner, A.9
Liu, X.10
Wan, J.11
Johnson, M.D.12
Lord, P.13
-
2
-
-
32444433202
-
Free radicals, metals and antioxidants in oxidative stress-induced cancer
-
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40.
-
(2006)
Chem Biol Interact
, vol.160
, pp. 1-40
-
-
Valko, M.1
Rhodes, C.J.2
Moncol, J.3
Izakovic, M.4
Mazur, M.5
-
3
-
-
0036139524
-
Reactive oxygen species and signal transduction
-
Finkel T. Reactive oxygen species and signal transduction. IUBMB Life 2001;52:3-6.
-
(2001)
IUBMB Life
, vol.52
, pp. 3-6
-
-
Finkel, T.1
-
4
-
-
0029758783
-
Redox modulation of tyrosine phos-phorylation-dependent signal transduction pathways
-
Monteiro HP, Stern A. Redox modulation of tyrosine phos-phorylation- dependent signal transduction pathways. Free Radic Biol Med 1996;21:323-333.
-
(1996)
Free Radic Biol Med
, vol.21
, pp. 323-333
-
-
Monteiro, H.P.1
Stern, A.2
-
5
-
-
48349107170
-
A new APE1/Ref-1 dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity
-
Ando K, Hirao S, Kabe Y, Ogura Y, Sato I, Yamaguchi Y, Wada T, Handa H. A new APE1/Ref-1 dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res 2008;36: 4327-4336.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4327-4336
-
-
Ando, K.1
Hirao, S.2
Kabe, Y.3
Ogura, Y.4
Sato, I.5
Yamaguchi, Y.6
Wada, T.7
Handa, H.8
-
7
-
-
0036086130
-
Free radicals in the physiological control of cell function
-
Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
-
(2002)
Physiol Rev
, vol.82
, pp. 47-95
-
-
Droge, W.1
-
8
-
-
33749986298
-
Free radicals and antioxidants in normal physiological functions and human disease
-
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 44-84
-
-
Valko, M.1
Leibfritz, D.2
Moncol, J.3
Cronin, M.T.4
Mazur, M.5
Telser, J.6
-
9
-
-
34648813720
-
ROS as signaling molecules: Mechanisms that generate specifi city in ROS homeostasis
-
D'Autrèaux B, Toledano MB. ROS as signaling molecules: mechanisms that generate specifi city in ROS homeostasis. Nat Rev Mol Cell Biol ;2007; 8; 813-824.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 813-824
-
-
D'Autrèaux, B.1
Toledano, M.B.2
-
10
-
-
0034680558
-
A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specifi c binding
-
Pastor N, Weinstein H, Jamison E, Brenowitz M. A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specifi c binding. J Mol Biol 2000;304:55-68.
-
(2000)
J Mol Biol
, vol.304
, pp. 55-68
-
-
Pastor, N.1
Weinstein, H.2
Jamison, E.3
Brenowitz, M.4
-
11
-
-
56149121299
-
Translocation of iron from lyso-somes into mitochondria is a key event during oxidative stress-induced hepatocellular injury
-
Uchiyama A, Kim JS, Kon K, Jaeschke H, Ikejima K, Watanabe S, Lemasters JJ. Translocation of iron from lyso-somes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology 2008;48: 1644-1654.
-
(2008)
Hepatology
, vol.48
, pp. 1644-1654
-
-
Uchiyama, A.1
Kim, J.S.2
Kon, K.3
Jaeschke, H.4
Ikejima, K.5
Watanabe, S.6
Lemasters, J.J.7
-
12
-
-
69949160564
-
Redox mechanisms in hepatic chronic wound healing and fi brogenesis
-
Novo E, Parola M. Redox mechanisms in hepatic chronic wound healing and fi brogenesis. Fibrogen Tissue Repair 2008;1:5-62.
-
(2008)
Fibrogen Tissue Repair
, vol.1
, pp. 5-62
-
-
Novo, E.1
Parola, M.2
-
13
-
-
0038475847
-
Protein carbonylation in human diseases
-
Dalle-Donne I, Giustarini D, Colombo R, Rossi R, Milzani A. Protein carbonylation in human diseases. Trends Mol Med 2003;9(4):169-176.
-
(2003)
Trends Mol Med
, vol.9
, Issue.4
, pp. 169-176
-
-
Dalle-Donne, I.1
Giustarini, D.2
Colombo, R.3
Rossi, R.4
Milzani, A.5
-
15
-
-
0033963704
-
Oxidative stress and gene regulation
-
Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000;28:463-499.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 463-499
-
-
Allen, R.G.1
Tresini, M.2
-
16
-
-
0028061444
-
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
-
Moi P, Chan K, Asunis I, Cao A, Kan YW. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 1994;91:9926-9930.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9926-9930
-
-
Moi, P.1
Chan, K.2
Asunis, I.3
Cao, A.4
Kan, Y.W.5
-
17
-
-
7244253081
-
Nrf2-Keap1 defi nes and physiologically important stress response mechanism
-
Motohashi H, Yamamoto M. Nrf2-Keap1 defi nes and physiologically important stress response mechanism. Trends Mol Med 2004;10:549-557.
-
(2004)
Trends Mol Med
, vol.10
, pp. 549-557
-
-
Motohashi, H.1
Yamamoto, M.2
-
18
-
-
34250359779
-
Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease
-
Aleksunes LM, Manautou JE. Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicol Pathol 2007;35:459-473.
-
(2007)
Toxicol Pathol
, vol.35
, pp. 459-473
-
-
Aleksunes, L.M.1
Manautou, J.E.2
-
19
-
-
9944255781
-
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
-
Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys 2005;433:342-350.
-
(2005)
Arch Biochem Biophys
, vol.433
, pp. 342-350
-
-
Katoh, Y.1
Iida, K.2
Kang, M.I.3
Kobayashi, A.4
Mizukami, M.5
Tong, K.I.6
McMahon, M.7
Hayes, J.D.8
Itoh, K.9
Yamamoto, M.10
-
20
-
-
0035963293
-
Functional characterization and role of Keap1 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H: Quinone oxidoreductase1 gene
-
Dhakshinamoorthy S, Jaiswal AK. Functional characterization and role of Keap1 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H: quinone oxidoreductase1 gene. Oncogene 2001;20:3906-3917.
-
(2001)
Oncogene
, vol.20
, pp. 3906-3917
-
-
Dhakshinamoorthy, S.1
Jaiswal, A.K.2
-
21
-
-
0032953192
-
Keap-1 represses nuclear activation of anti-oxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M. Keap-1 represses nuclear activation of anti-oxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999;13:76-86.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
22
-
-
3843104763
-
Redox-regulated turnover of Nrf2 is determined by at least two seperate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
-
McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. Redox-regulated turnover of Nrf2 is determined by at least two seperate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J Biol Chem 2004;279:31556-31567.
-
(2004)
J Biol Chem
, vol.279
, pp. 31556-31567
-
-
McMahon, M.1
Thomas, N.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
23
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Conner T, Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 2003;8:379-391.
-
(2003)
Genes Cells
, vol.8
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Conner, T.5
Yamamoto, M.6
-
24
-
-
0027403024
-
Kelch encodes a component of intercellular bridges in Drosophila egg
-
Xue F, Cooley L. Kelch encodes a component of intercellular bridges in Drosophila egg chambers. Cell 1993;72: 681-693.
-
(1993)
Chambers. Cell
, vol.72
, pp. 681-693
-
-
Xue, F.1
Cooley, L.2
-
25
-
-
0037183998
-
The Keap-1 BTB/POZ dimeriza-tion function is required to sequester Nrf2 in cytoplasm
-
Kipper LM, Mulchay RT. The Keap-1 BTB/POZ dimeriza-tion function is required to sequester Nrf2 in cytoplasm. J Biol Chem 2002;277:36544-36552.
-
(2002)
J Biol Chem
, vol.277
, pp. 36544-36552
-
-
Kipper, L.M.1
Mulchay, R.T.2
-
26
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007;47:89-116.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
27
-
-
0037821802
-
Keap1 dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1 dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 2003;278:21592-21600.
-
(2003)
J Biol Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
28
-
-
0013282861
-
Increased protein stability as a mechanism that enhances Nrf2 mediated transcriptional activation of the antioxidant response element
-
Degradation of Nrf2 by the 26S protea-some
-
Nguyen T, Sherrat PJ, Huang HC, Yang CS, Pickett CB. Increased protein stability as a mechanism that enhances Nrf2 mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26S protea-some. J Biol Chem 2003;278:4536-4541.
-
(2003)
J Biol Chem
, vol.278
, pp. 4536-4541
-
-
Nguyen, T.1
Sherrat, P.J.2
Huang, H.C.3
Yang, C.S.4
Pickett, C.B.5
-
29
-
-
4544294365
-
The Keap1-BTB protein is an adapter that bridges Nrf2 to Cul3-based E3 ligase: Oxidative stress sensing by Cul3-Keap1 ligase
-
Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. The Keap1-BTB protein is an adapter that bridges Nrf2 to Cul3-based E3 ligase: oxidative stress sensing by Cul3-Keap1 ligase. Mol Cell Biol 2004;24:8477-8486.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8477-8486
-
-
Cullinan, S.B.1
Gordan, J.D.2
Jin, J.3
Harper, J.W.4
Diehl, J.A.5
-
30
-
-
3042794972
-
Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxi-dant and detoxifying enzymes
-
Kobayashi A, Ohta T, Yamamoto M. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxi-dant and detoxifying enzymes. Methods Enzymol 2004;378: 273-286.
-
(2004)
Methods Enzymol
, vol.378
, pp. 273-286
-
-
Kobayashi, A.1
Ohta, T.2
Yamamoto, M.3
-
31
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 2004;24:10941-10953.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
32
-
-
11144264663
-
BTB protein Keap1 targets antioxi-dant transcription factor Nrf2 for ubiqutination by the Cullin 3-Roc1 ligase
-
Furukawa M, Xiong Y. BTB protein Keap1 targets antioxi-dant transcription factor Nrf2 for ubiqutination by the Cullin 3-Roc1 ligase. Mol Cell Biol 2005;25:162-171.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 162-171
-
-
Furukawa, M.1
Xiong, Y.2
-
33
-
-
33747728194
-
Dimerisation of substrate adapter can facilitate cullin-mediated ubiquitylation of proteins by a " tethering " mechanism: A two site interaction model for the Nrf2-Keap1 complex
-
McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. Dimerisation of substrate adapter can facilitate cullin-mediated ubiquitylation of proteins by a " tethering " mechanism: a two site interaction model for the Nrf2-Keap1 complex. J Biol Chem 2006;281:24756-24768.
-
(2006)
J Biol Chem
, vol.281
, pp. 24756-24768
-
-
McMahon, M.1
Thomas, N.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
34
-
-
33747606306
-
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
-
Lo SC, Li X, Henzl MT, Beamer LJ, Hannink M. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J 2006;25:3605-3617.
-
(2006)
EMBO J
, vol.25
, pp. 3605-3617
-
-
Lo, S.C.1
Li, X.2
Henzl, M.T.3
Beamer, L.J.4
Hannink, M.5
-
35
-
-
33344463325
-
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
-
Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol 2006;26:2887-2900.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2887-2900
-
-
Tong, K.I.1
Katoh, Y.2
Kusunoki, H.3
Itoh, K.4
Tanaka, T.5
Yamamoto, M.6
-
36
-
-
33750613056
-
Two site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
-
Tong KI, Kobayashi A, Katsuoka F, Yamamoto M. Two site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol Chem 2006;387: 1311-1320.
-
(2006)
Biol Chem
, vol.387
, pp. 1311-1320
-
-
Tong, K.I.1
Kobayashi, A.2
Katsuoka, F.3
Yamamoto, M.4
-
37
-
-
0242580049
-
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
-
Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 2003;23:8137-8151.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8137-8151
-
-
Zhang, D.D.1
Hannink, M.2
-
38
-
-
33344469643
-
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
-
Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 2006;26:221-229.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 221-229
-
-
Kobayashi, A.1
Kang, M.I.2
Watai, Y.3
Tong, K.I.4
Shibata, T.5
Uchida, K.6
Yamamoto, M.7
-
40
-
-
37549032763
-
An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance
-
Lee OH, Jain AK, Papusha V, Jaiswal AK. An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance. J Biol Chem 2007;282:36412-36420.
-
(2007)
J Biol Chem
, vol.282
, pp. 36412-36420
-
-
Lee, O.H.1
Jain, A.K.2
Papusha, V.3
Jaiswal, A.K.4
-
41
-
-
24744453945
-
Specifi c patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
-
Hong F, Sekhar KR, Freeman ML, Liebler DC. Specifi c patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J Biol Chem 2005; 280:31768-31775.
-
(2005)
J Biol Chem
, vol.280
, pp. 31768-31775
-
-
Hong, F.1
Sekhar, K.R.2
Freeman, M.L.3
Liebler, D.C.4
-
42
-
-
68749120854
-
Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response
-
Sun Z, Huang Z, Zhang DD. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One 2009; 4:e6588-e6596 .
-
(2009)
PLoS One
, vol.4
-
-
Sun, Z.1
Huang, Z.2
Zhang, D.D.3
-
43
-
-
0034704079
-
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
-
Yu R, Chen C, Mo YY, Hebbar V, Owuor ED, Tan TH, Kong AN. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem 2000;275:39907-39913.
-
(2000)
J Biol Chem
, vol.275
, pp. 39907-39913
-
-
Yu, R.1
Chen, C.2
Mo, Y.Y.3
Hebbar, V.4
Owuor, E.D.5
Tan, T.H.6
Kong, A.N.7
-
44
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser40 by protein kinase C regulates antioxidant response element-mediated transcription
-
Huang HC. Phosphorylation of Nrf2 at Ser40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 2002;277:42769-42774.
-
(2002)
J Biol Chem
, vol.277
, pp. 42769-42774
-
-
Huang, H.C.1
-
45
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
Nguyen T, Sherratt PJ, Pickett CB. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 2003;43: 233-260.
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
46
-
-
36748999400
-
New modes of transla-tional control in development, behaviour, and disease
-
Sonenberg N, Hinnebusch AG. New modes of transla-tional control in development, behaviour, and disease. Mol Cell 2007; 28:721-729 .
-
(2007)
Mol Cell
, vol.28
, pp. 721-729
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
47
-
-
60149091189
-
Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
-
Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 2009;136:731-745.
-
(2009)
Cell
, vol.136
, pp. 731-745
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
48
-
-
58149469090
-
Translational control of long-lasting synaptic plasticity and memory
-
Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. Translational control of long-lasting synaptic plasticity and memory. Neuron 2009; 61:10-26 .
-
(2009)
Neuron
, vol.61
, pp. 10-26
-
-
Costa-Mattioli, M.1
Sossin, W.S.2
Klann, E.3
Sonenberg, N.4
-
49
-
-
66349129338
-
Acetylation of Nrf2 by p300/ CBP: Augment promoter specifi c DNA binding of Nrf2 during the antioxidant response
-
Sun Z, Chin YE, Zhang DD. Acetylation of Nrf2 by p300/ CBP: augment promoter specifi c DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol 2009;29: 2658-2672.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2658-2672
-
-
Sun, Z.1
Chin, Y.E.2
Zhang, D.D.3
-
50
-
-
0034752461
-
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
-
Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A, Yamamoto M. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 2001;6:857-868.
-
(2001)
Genes Cells
, vol.6
, pp. 857-868
-
-
Katoh, Y.1
Itoh, K.2
Yoshida, E.3
Miyagishi, M.4
Fukamizu, A.5
Yamamoto, M.6
-
51
-
-
0030606239
-
The transcriptional coactivators p300 and CBP are histone acetyltransferases
-
Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 1996; 87:953-959.
-
(1996)
Cell
, vol.87
, pp. 953-959
-
-
Ogryzko, V.V.1
Schiltz, R.L.2
Russanova, V.3
Howard, B.H.4
Nakatani, Y.5
-
52
-
-
23844475091
-
Nuclear import and export signals in control of Nrf2
-
Jain AK, Bloom DA, Jaiswal AK. Nuclear import and export signals in control of Nrf2. J Biol Chem 2005;280: 29158-29168.
-
(2005)
J Biol Chem
, vol.280
, pp. 29158-29168
-
-
Jain, A.K.1
Bloom, D.A.2
Jaiswal, A.K.3
-
53
-
-
33748752586
-
Nrf2 posses a redox-sensitive nuclear exporting signal in the Neh 5 transactivation domain
-
Li W, Yu SW, Kong AN. Nrf2 posses a redox-sensitive nuclear exporting signal in the Neh 5 transactivation domain. J Biol Chem 2006;281:27251-27263.
-
(2006)
J Biol Chem
, vol.281
, pp. 27251-27263
-
-
Li, W.1
Yu, S.W.2
Kong, A.N.3
-
54
-
-
25444449520
-
Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleo-cytoplasmic shuttling by Keap1
-
Nguyen T, Sherratt PJ, Nioi P, Yang CS, Pickett CB. Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleo-cytoplasmic shuttling by Keap1. J Biol Chem 2005;280: 32485-32492.
-
(2005)
J Biol Chem
, vol.280
, pp. 32485-32492
-
-
Nguyen, T.1
Sherratt, P.J.2
Nioi, P.3
Yang, C.S.4
Pickett, C.B.5
-
55
-
-
18944373186
-
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism
-
Velichkova M, Hasson T. Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism. Mol Cell Biol 2005;25:4501-4513.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4501-4513
-
-
Velichkova, M.1
Hasson, T.2
-
56
-
-
33744953050
-
Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
-
Jain AK, Jaiswal A K. Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem 2006;281: 12132-12142.
-
(2006)
J Biol Chem
, vol.281
, pp. 12132-12142
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
57
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 2003;35:238-245.
-
(2003)
Nat Genet
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
Motohashi, H.4
Noda, S.5
Takahashi, S.6
Imakado, S.7
Kotsuji, T.8
Otsuka, F.9
Roop, D.R.10
Harada, T.11
Engel, J.D.12
Yamamoto, M.13
-
58
-
-
48749085399
-
Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
-
Rubiolo JA, Mithieux G, Vega F V. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol 2008; 591:66-72.
-
(2008)
Eur J Pharmacol
, vol.591
, pp. 66-72
-
-
Rubiolo, J.A.1
Mithieux, G.2
Vega, F.V.3
-
59
-
-
0036371485
-
Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
-
Ishii T, Itoh K, Yamamoto M. Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements. Methods Enzymol 2002;348:182-190.
-
(2002)
Methods Enzymol
, vol.348
, pp. 182-190
-
-
Ishii, T.1
Itoh, K.2
Yamamoto, M.3
-
60
-
-
0025948113
-
The antioxidant responsive element activation by oxidative stress and identi-fication of the DNA consensus sequence required for functional activity
-
Rushmore TH, Morton MR, Pickett CB. The antioxidant responsive element activation by oxidative stress and identi-fication of the DNA consensus sequence required for functional activity. J Biol Chem 1991;266:11632-11639.
-
(1991)
J Biol Chem
, vol.266
, pp. 11632-11639
-
-
Rushmore, T.H.1
Morton, M.R.2
Pickett, C.B.3
-
61
-
-
3042835514
-
Regulation of antioxidant response element-dependent induction of detoxifying enzyme synthesis
-
Jaiswal AK. Regulation of antioxidant response element-dependent induction of detoxifying enzyme synthesis. Methods Enzymol 2004;378:221-238.
-
(2004)
Methods Enzymol
, vol.378
, pp. 221-238
-
-
Jaiswal, A.K.1
-
62
-
-
0042330074
-
Identifi cation of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidore-ductase 1 gene: Reassessment of the ARE consensus sequence
-
Nioi P, McMahon M, Itoh K, Yamamoto M, Hayes JD. Identifi cation of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidore-ductase 1 gene: reassessment of the ARE consensus sequence. Biochem J 2003;374:337-348.
-
(2003)
Biochem J
, vol.374
, pp. 337-348
-
-
Nioi, P.1
McMahon, M.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
63
-
-
0031000208
-
Functional antioxidant responsive elements
-
Wasserman WW, Fahl WE. Functional antioxidant responsive elements. Proc Natl Acad Sci USA 1997;94:5361-5366.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5361-5366
-
-
Wasserman, W.W.1
Fahl, W.E.2
-
64
-
-
21644467011
-
Selective induction of the tumor marker glutathione S-transferase P1 by protea-some inhibitors
-
Usami H, Kusano Y, Kumagai T, Osada S, Itoh K, Kobayashi A, Yamamoto M, Uchida K. Selective induction of the tumor marker glutathione S-transferase P1 by protea-some inhibitors. J Biol Chem 2005;280:25267-25276.
-
(2005)
J Biol Chem
, vol.280
, pp. 25267-25276
-
-
Usami, H.1
Kusano, Y.2
Kumagai, T.3
Osada, S.4
Itoh, K.5
Kobayashi, A.6
Yamamoto, M.7
Uchida, K.8
-
65
-
-
0028802636
-
The rat quinone reductase antioxidant response element
-
Favreau LV, Pickett CB. The rat quinone reductase antioxidant response element. J Biol Chem 1995;270: 24468-24474.
-
(1995)
J Biol Chem
, vol.270
, pp. 24468-24474
-
-
Favreau, L.V.1
Pickett, C.B.2
-
66
-
-
0034190372
-
Regulation of redox glutathione levels and gene transcription in lung infl ammation: Therapeutic approaches
-
Rahman I, MacNee W. Regulation of redox glutathione levels and gene transcription in lung infl ammation: therapeutic approaches. Free Radic Biol Med 2000;28:1405-1420.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 1405-1420
-
-
Rahman, I.1
MacNee, W.2
-
67
-
-
2642671110
-
Constitutive expression is mediated by an adjacent AP-1 site
-
An electrophile responsive element (EpRE) regulates β-naphthofl avone induction of the human γ-glutamylcysteine synthetase regulatory subunit gene
-
Moinova HR, Mulcahy RT. An electrophile responsive element (EpRE) regulates β-naphthofl avone induction of the human γ-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site. J Biol Chem 1998;273:14683-14689.
-
(1998)
J Biol Chem
, vol.273
, pp. 14683-14689
-
-
Moinova, H.R.1
Mulcahy, R.T.2
-
68
-
-
0141885079
-
Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway
-
Alam J, Cook JL. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr Pharm Des 2003;9:2499-2511.
-
(2003)
Curr Pharm des
, vol.9
, pp. 2499-2511
-
-
Alam, J.1
Cook, J.L.2
-
69
-
-
0032542213
-
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
-
Venugopal R, Jaiswal AK. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene 1998;17:3145-3156.
-
(1998)
Oncogene
, vol.17
, pp. 3145-3156
-
-
Venugopal, R.1
Jaiswal, A.K.2
-
70
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through anti-oxidant response elements
-
Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through anti-oxidant response elements. Biochem Biophys Res Commun 1997;236:313-322.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
71
-
-
0034685897
-
Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
-
Nguyen T, Huang HC, Pickett CB. Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J Biol Chem 2000;275: 15466-15473.
-
(2000)
J Biol Chem
, vol.275
, pp. 15466-15473
-
-
Nguyen, T.1
Huang, H.C.2
Pickett, C.B.3
-
72
-
-
0035940984
-
Functional characterization of transcription regulators that interact with the electrophile response element
-
Zhu M, Fahl WE. Functional characterization of transcription regulators that interact with the electrophile response element. Biochem Biophys Res Commun 2001;289:212-219.
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 212-219
-
-
Zhu, M.1
Fahl, W.E.2
-
73
-
-
0023572209
-
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
-
Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 1987;238:1386-1392.
-
(1987)
Science
, vol.238
, pp. 1386-1392
-
-
Bohmann, D.1
Bos, T.J.2
Admon, A.3
Nishimura, T.4
Vogt, P.K.5
Tjian, R.6
-
74
-
-
0029592113
-
Differential regulation of AP-1 and novel TRE-specifi c DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells
-
Barnett SC, Rosario M, Doyle A, Kilbey A, Lovatt A, Gillespie DA. Differential regulation of AP-1 and novel TRE-specifi c DNA-binding complexes during differentiation of oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells. Development 1995;121:3969-3977.
-
(1995)
Development
, vol.121
, pp. 3969-3977
-
-
Barnett, S.C.1
Rosario, M.2
Doyle, A.3
Kilbey, A.4
Lovatt, A.5
Gillespie, D.A.6
-
75
-
-
0030791154
-
The world according to Maf
-
Motohashi H, Shavit JA, Igarashi K, Yamamoto M, Engel JD. The world according to Maf. Nucleic Acids Res 1997;25: 2953-2959.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 2953-2959
-
-
Motohashi, H.1
Shavit, J.A.2
Igarashi, K.3
Yamamoto, M.4
Engel, J.D.5
-
76
-
-
0037043822
-
C-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction
-
Dhakshinamoorthy S, Jaiswal AK. c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction. Oncogene 2002;21:5301-5312.
-
(2002)
Oncogene
, vol.21
, pp. 5301-5312
-
-
Dhakshinamoorthy, S.1
Jaiswal, A.K.2
-
77
-
-
0023798751
-
Fos and Jun: The AP-1 connection
-
Curran T, Franza BR, Jr. Fos and Jun: the AP-1 connection. Cell 1988;55:395-397.
-
(1988)
Cell
, vol.55
, pp. 395-397
-
-
Curran, T.1
Franza Jr., B.R.2
-
78
-
-
0029906134
-
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinine oxidoreductase1 gene
-
Venugopal R, Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinine oxidoreductase1 gene. Proc Natl Acad Sci USA 1996;93: 14960-14965.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14960-14965
-
-
Venugopal, R.1
Jaiswal, A.K.2
-
79
-
-
2342514015
-
An important role of Nrf2-ARE pathway in the cellular defense mechanism
-
Lee JM, Johnson JA. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Bio 2004;37:139-143.
-
(2004)
J Biochem Mol Bio
, vol.37
, pp. 139-143
-
-
Lee, J.M.1
Johnson, J.A.2
-
80
-
-
0036240610
-
Enhanced expression of the transcription factor Nrf2 by cancer chemo-preventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
-
Kwak MK, Itoh K, Yamamoto M, Kensler TW. Enhanced expression of the transcription factor Nrf2 by cancer chemo-preventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 2002;22: 2883-2892.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2883-2892
-
-
Kwak, M.K.1
Itoh, K.2
Yamamoto, M.3
Kensler, T.W.4
-
81
-
-
61849160406
-
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes
-
Reisman SA, Buckley DB, Tanaka Y, Klaassen CD. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. T oxicol Appl Pharmacol 2009;236:109-114.
-
(2009)
T Oxicol Appl Pharmacol
, vol.236
, pp. 109-114
-
-
Reisman, S.A.1
Buckley, D.B.2
Tanaka, Y.3
Klaassen, C.D.4
-
82
-
-
0036518402
-
NAD(P)H:quinone oxidoreductase (NQO-1) polymorphism, exposure to benzene, and predisposition to disease: A HuGE review
-
Nebert DW, Roe AL, Vandale SE, Bingham E, Oakley GG. NAD(P)H:quinone oxidoreductase (NQO-1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review. Genet Med 2002;4:62-70.
-
(2002)
Genet Med
, vol.4
, pp. 62-70
-
-
Nebert, D.W.1
Roe, A.L.2
Vandale, S.E.3
Bingham, E.4
Oakley, G.G.5
-
83
-
-
7544236965
-
Quinone reductases multitasking in the metabolic world
-
Ross D. Quinone reductases multitasking in the metabolic world. Drug Metab Rev 2004;36:639-654.
-
(2004)
Drug Metab Rev
, vol.36
, pp. 639-654
-
-
Ross, D.1
-
85
-
-
33645111448
-
Glutathione S-Transferase polymorphisms: Cancer incidence and therapy
-
McIlwain CC, Townsend DM, Tew KD. Glutathione S-Transferase polymorphisms: cancer incidence and therapy. Oncogene 2006;25:1639-1648.
-
(2006)
Oncogene
, vol.25
, pp. 1639-1648
-
-
McIlwain, C.C.1
Townsend, D.M.2
Tew, K.D.3
-
86
-
-
33645120407
-
Uridine diphosphoglucuronosyl trans-ferase pharmacogenetics and cancer
-
Nagar S, Remmel RP. Uridine diphosphoglucuronosyl trans-ferase pharmacogenetics and cancer. Oncogene 2006;25: 1659-1672.
-
(2006)
Oncogene
, vol.25
, pp. 1659-1672
-
-
Nagar, S.1
Remmel, R.P.2
-
87
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420:885-891.
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
88
-
-
21744445077
-
Nrf2, a multi-organ protector?
-
Lee JM, Li J, Johnson DA, Stein TD, Kraft AD, Calkins MJ, Jakel RJ, Johnson JA. Nrf2, a multi-organ protector? FASEB J 2005;19:1061-1066.
-
(2005)
FASEB J
, vol.19
, pp. 1061-1066
-
-
Lee, J.M.1
Li, J.2
Johnson, D.A.3
Stein, T.D.4
Kraft, A.D.5
Calkins, M.J.6
Jakel, R.J.7
Johnson, J.A.8
-
89
-
-
0034672595
-
Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
-
Chan JY, Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta 2000;1517:19-26.
-
(2000)
Biochim Biophys Acta
, vol.1517
, pp. 19-26
-
-
Chan, J.Y.1
Kwong, M.2
-
90
-
-
0347481377
-
Defi ciency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress
-
Leung L, Kwong M, Hou S, Lee C, Chan JY. Defi ciency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem 2003;278:48021-48029.
-
(2003)
J Biol Chem
, vol.278
, pp. 48021-48029
-
-
Leung, L.1
Kwong, M.2
Hou, S.3
Lee, C.4
Chan, J.Y.5
-
91
-
-
1242296811
-
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
-
DOI 10.1073/pnas.0307301101
-
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modifi ed by inducers. Proc Natl Acad Sci USA 2004;101:2040-2045. (Pubitemid 38229011)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.7
, pp. 2040-2045
-
-
Wakabayashi, N.1
Dinkova-Kostova, A.T.2
Holtzclaw, W.D.3
Kang, M.-I.4
Kobayashi, A.5
Yamamoto, M.6
Kensler, T.W.7
Talalay, P.8
-
92
-
-
28144445947
-
Hepatocyte-specifi c deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
-
Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Hepatocyte-specifi c deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 2006; 339:79-88.
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 79-88
-
-
Okawa, H.1
Motohashi, H.2
Kobayashi, A.3
Aburatani, H.4
Kensler, T.W.5
Yamamoto, M.6
-
93
-
-
0034071372
-
Regulation of gamma-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidants defences
-
Wild AC, Mulchahy RT. Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidants defences. Free Radic Res 2000;32:281-301.
-
(2000)
Free Radic Res
, vol.32
, pp. 281-301
-
-
Wild, A.C.1
Mulchahy, R.T.2
-
94
-
-
0037101768
-
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
-
Chanas SA, Jiang Q, McMahon M, McWalter GK, McLellan LI, Elcombe CR, Henderson CJ, Wolf CR, Moffat GJ, Itoh K, Yamamoto M, Hayes JD. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J 2002;365:405-416.
-
(2002)
Biochem J
, vol.365
, pp. 405-416
-
-
Chanas, S.A.1
Jiang, Q.2
McMahon, M.3
McWalter, G.K.4
McLellan, L.I.5
Elcombe, C.R.6
Henderson, C.J.7
Wolf, C.R.8
Moffat, G.J.9
Itoh, K.10
Yamamoto, M.11
Hayes, J.D.12
-
95
-
-
0033584867
-
Regulation of gam-maglutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2
-
Wild AC, Moinova HR, Mulcahy RT. Regulation of gam-maglutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J Biol Chem 1999;274: 33627-33636.
-
(1999)
J Biol Chem
, vol.274
, pp. 33627-33636
-
-
Wild, A.C.1
Moinova, H.R.2
Mulcahy, R.T.3
-
96
-
-
21944452087
-
Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
-
Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY, Lu SC. Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol 2005;25:5933-5946.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5933-5946
-
-
Yang, H.1
Magilnick, N.2
Lee, C.3
Kalmaz, D.4
Ou, X.5
Chan, J.Y.6
Lu, S.C.7
-
97
-
-
65049090071
-
Environmental toxicity, redox signaling and lung infl ammation: The role of glutathione
-
Biswas SK, Rahman I. Environmental toxicity, redox signaling and lung infl ammation: the role of glutathione. Mol Aspects Med 2009;30:60-76.
-
(2009)
Mol Aspects Med
, vol.30
, pp. 60-76
-
-
Biswas, S.K.1
Rahman, I.2
-
98
-
-
54949139208
-
Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)- sulfoximine: Involvement of Nrf2 activation
-
Lee HR, Cho JM, Shin DH, Yong CS, Choi HG, Wakabayashi N, Kwak MK. Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)- sulfoximine: involvement of Nrf2 activation. Mol Cell Biochem 2008; 318:23-31.
-
(2008)
Mol Cell Biochem
, vol.318
, pp. 23-31
-
-
Lee, H.R.1
Cho, J.M.2
Shin, D.H.3
Yong, C.S.4
Choi, H.G.5
Wakabayashi, N.6
Kwak, M.K.7
-
99
-
-
1542723493
-
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione syn, thesis, which is reversible with lipoic acid
-
Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 2004;101: 3381-3386.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3381-3386
-
-
Suh, J.H.1
Shenvi, S.V.2
Dixon, B.M.3
Liu, H.4
Jaiswal, A.K.5
Liu, R.M.6
Hagen, T.M.7
-
100
-
-
20344405468
-
The GI-GPx gene is a target for Nrf2
-
Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohe R. The GI-GPx gene is a target for Nrf2. Mol Cell Biol 2005; 25:4914-4923.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4914-4923
-
-
Banning, A.1
Deubel, S.2
Kluth, D.3
Zhou, Z.4
Brigelius-Flohe, R.5
-
101
-
-
58649100237
-
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
-
Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S. Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress. Free Radic Biol Med 2009;46:443-453.
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 443-453
-
-
Harvey, C.J.1
Thimmulappa, R.K.2
Singh, A.3
Blake, D.J.4
Ling, G.5
Wakabayashi, N.6
Fujii, J.7
Myers, A.8
Biswal, S.9
-
102
-
-
0033956744
-
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxy-anisole and ethoxyquin
-
Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, Yamamoto M. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxy-anisole and ethoxyquin. Biochem Soc Trans 2000;28:33-41.
-
(2000)
Biochem Soc Trans
, vol.28
, pp. 33-41
-
-
Hayes, J.D.1
Chanas, S.A.2
Henderson, C.J.3
McMahon, M.4
Sun, C.5
Moffat, G.J.6
Wolf, C.R.7
Yamamoto, M.8
-
103
-
-
0029758201
-
The GSTM1 genetic polymorphism in healthy Saudi Arabians and Filipinos, and Saudi Arabians with coronary atherosclerosis
-
Evans DAP, Seidegrd J, Narayanan N. The GSTM1 genetic polymorphism in healthy Saudi Arabians and Filipinos, and Saudi Arabians with coronary atherosclerosis. Pharmacoge-netics 1996;6:365-367.
-
(1996)
Pharmacoge-netics
, vol.6
, pp. 365-367
-
-
Dap, E.1
Seidegrd, J.2
Narayanan, N.3
-
104
-
-
0034637481
-
Identifi cation characterization and crystal structure of the Omega class glutathione transferases
-
Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J. Identifi cation, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem 2000;275:24798-24806.
-
(2000)
J Biol Chem
, vol.275
, pp. 24798-24806
-
-
Board, P.G.1
Coggan, M.2
Chelvanayagam, G.3
Easteal, S.4
Jermiin, L.S.5
Schulte, G.K.6
Danley, D.E.7
Hoth, L.R.8
Griffor, M.C.9
Kamath, A.V.10
Rosner, M.H.11
Chrunyk, B.A.12
Perregaux, D.E.13
Gabel, C.A.14
Geoghegan, K.F.15
Pandit, J.16
-
105
-
-
0029561598
-
The glutathione S-transferase super-gene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
-
Hayes JD, Pulford DJ. The glutathione S-transferase super-gene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995;30:445-600.
-
(1995)
Crit Rev Biochem Mol Biol
, vol.30
, pp. 445-600
-
-
Hayes, J.D.1
Pulford, D.J.2
-
106
-
-
0031439569
-
Zeta, a novel class of glutathione transferases in a range of species from plants to humans
-
Board PG, Baker RT, Chelvanayagam G, Jermiin LS. Zeta, a novel class of glutathione transferases in a range of species from plants to humans. Biochem J 1997;328:929-935.
-
(1997)
Biochem J
, vol.328
, pp. 929-935
-
-
Board, P.G.1
Baker, R.T.2
Chelvanayagam, G.3
Jermiin, L.S.4
-
107
-
-
37449000924
-
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection
-
Reddy NM, Kleeberger SR, Yamamoto M, Kensler TW, Scollick C, Biswal S, Reddy SP. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics 2007;32:74-81.
-
(2007)
Physiol Genomics
, vol.32
, pp. 74-81
-
-
Reddy, N.M.1
Kleeberger, S.R.2
Yamamoto, M.3
Kensler, T.W.4
Scollick, C.5
Biswal, S.6
Reddy, S.P.7
-
108
-
-
0032212888
-
Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1
-
Sherratt PJ, Manson MM, Thomson AM, Hissink EA, Neal GE, van Bladeren PJ, Green T, Hayes JD. Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1. Biochem J 1998; 335:619-630.
-
(1998)
Biochem J
, vol.335
, pp. 619-630
-
-
Sherratt, P.J.1
Manson, M.M.2
Thomson, A.M.3
Hissink, E.A.4
Neal, G.E.5
Van Bladeren, P.J.6
Green, T.7
Hayes, J.D.8
-
109
-
-
0342327333
-
The role of human glutathione trans-ferases and epoxide hydrolases in the metabolism of xenobi-otics
-
Seidegard J, Ekstrom G. The role of human glutathione trans-ferases and epoxide hydrolases in the metabolism of xenobi-otics. Environ Health Perspect 1997;105(Supp 4):791-799.
-
(1997)
Environ Health Perspect
, vol.105
, Issue.SUPPL. 4
, pp. 791-799
-
-
Seidegard, J.1
Ekstrom, G.2
-
110
-
-
0000008949
-
Gene expression of DT diaphorase (NQO-1) in cancer cells
-
In: Forman HJ, Cadenas E, editors New York: Chapman & Hall
-
Radjendirane V, Joseph P, Jaiswal AK. Gene expression of DT diaphorase (NQO-1) in cancer cells. In: Forman HJ, Cadenas E, editors. Oxidative stress and signal transduction. New York: Chapman & Hall; 1997. p 441-475.
-
(1997)
Oxidative Stress and Signal Transduction
, pp. 441-475
-
-
Radjendirane, V.1
Joseph, P.2
Jaiswal, A.K.3
-
111
-
-
0026612119
-
DT diaphorase and cancer chemotherapy
-
Riley RJ, Workman P. DT diaphorase and cancer chemotherapy. Biochem Pharm ;1992; 43; 1657-1669.
-
(1992)
Biochem Pharm
, vol.43
, pp. 1657-1669
-
-
Riley, R.J.1
Workman, P.2
-
112
-
-
0026755187
-
Regulation of human NAD(P)H: Quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element
-
Li Y, Jaiswal AK. Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J Biol Chem 1992;267:15097-15104.
-
(1992)
J Biol Chem
, vol.267
, pp. 15097-15104
-
-
Li, Y.1
Jaiswal, A.K.2
-
113
-
-
30144431738
-
UDP-glucuronosyltransferase 1A6: Structural, functional, and regulatory aspects
-
Bock KW, Kohle C. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol 2005;400:57-75.
-
(2005)
Methods Enzymol
, vol.400
, pp. 57-75
-
-
Bock, K.W.1
Kohle, C.2
-
114
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 2001;59:169-177.
-
(2001)
Toxicol Sci
, vol.59
, pp. 169-177
-
-
Enomoto, A.1
Itoh, K.2
Nagayoshi, E.3
Haruta, J.4
Kimura, T.5
O'Connor, T.6
Harada, T.7
Yamamoto, M.8
-
115
-
-
17744408754
-
Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells
-
Münzel PA, Schmohl S, Buckler F, Jaehrling J, Raschko FT, Kohle C, Bock KW. Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells. Biochem Pharmacol 2003;66:841-847.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 841-847
-
-
Münzel, P.A.1
Schmohl, S.2
Buckler, F.3
Jaehrling, J.4
Raschko, F.T.5
Kohle, C.6
Bock, K.W.7
-
116
-
-
0035853157
-
Sensitivity to carcino-genesis is increased and chemoprotective effi cacy of enzyme inducers is lost in nrf2 transcription factor-defi cient mice
-
Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler T W. Sensitivity to carcino-genesis is increased and chemoprotective effi cacy of enzyme inducers is lost in nrf2 transcription factor-defi cient mice. Proc Natl Acad Sci USA 2001;98:3410-3415.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
118
-
-
2042546096
-
Balancing acts: Molecular control of mammalian iron metabolism
-
Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004;117:285-297.
-
(2004)
Cell
, vol.117
, pp. 285-297
-
-
Hentze, M.W.1
Muckenthaler, M.U.2
Andrews, N.C.3
-
119
-
-
1842608845
-
Iron metabolism and IRE/IRP regulatory system: An update
-
Pantopoulos K. Iron metabolism and IRE/IRP regulatory system: an update. Ann NY Acad Sci 2004;1012:1-13.
-
(2004)
Ann NY Acad Sci
, vol.1012
, pp. 1-13
-
-
Pantopoulos, K.1
-
120
-
-
34548307253
-
Excess capacity of the Iron regulatory protein system
-
Wei W, Di X, D'Agostino RB, Jr, Torti SV, Torti FM. Excess capacity of the Iron regulatory protein system. J Biol Chem 2007;282:24650-24659.
-
(2007)
J Biol Chem
, vol.282
, pp. 24650-24659
-
-
Wei, W.1
Di D'Agostino X, R.B.2
Torti Jr., S.V.3
Torti, F.M.4
-
121
-
-
27244457379
-
DNA and mRNA elements with complimentary response to hemin, antioxidant inducer, and iron control ferritin-L expression
-
Hintze KJ, Theil EC. DNA and mRNA elements with complimentary response to hemin, antioxidant inducer, and iron control ferritin-L expression. Proc Natl Acad Sci USA 2005;102:15048-15052.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15048-15052
-
-
Hintze, K.J.1
Theil, E.C.2
-
122
-
-
0037462675
-
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones
-
Pietsch EC, Chan JY, Torti FM, Torti SV. Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones. J Biol Chem 2003;278: 2361-2369.
-
(2003)
J Biol Chem
, vol.278
, pp. 2361-2369
-
-
Pietsch, E.C.1
Chan, J.Y.2
Torti, F.M.3
Torti, S.V.4
-
123
-
-
0034682761
-
Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: In vivo role of ferritin ferroxi dase activity
-
Cozzi A, Corsi B, Levi S, Santambrogio P, Albertini A, Arosio P. Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxi dase activity. J Biol Chem 2000;275:25122-2512.
-
(2000)
J Biol Chem
, vol.275
, pp. 25122-2512
-
-
Cozzi, A.1
Corsi, B.2
Levi, S.3
Santambrogio, P.4
Albertini, A.5
Arosio, P.6
-
124
-
-
0035397392
-
Ferritin and the response to oxidative stress
-
Orino K, Lehman L, Tsuji Y, Ayaki H, Torti SV, Torti FM. Ferritin and the response to oxidative stress. Biochem J 2001;357:241-247.
-
(2001)
Biochem J
, vol.357
, pp. 241-247
-
-
Orino, K.1
Lehman, L.2
Tsuji, Y.3
Ayaki, H.4
Torti, S.V.5
Torti, F.M.6
-
125
-
-
0035834304
-
Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases
-
Guo X, Shin VY, Cho CH. Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases. Life Sci 2001;69:3113-3119.
-
(2001)
Life Sci
, vol.69
, pp. 3113-3119
-
-
Guo, X.1
Shin, V.Y.2
Cho, C.H.3
-
126
-
-
0029411321
-
Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
-
Prestera T, Talalay P, Alam J, Ahn YI, Lee PJ, Choi AM. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1995;1:827-837.
-
(1995)
Mol Med
, vol.1
, pp. 827-837
-
-
Prestera, T.1
Talalay, P.2
Alam, J.3
Ahn, Y.I.4
Lee, P.J.5
Choi, A.M.6
-
127
-
-
0029945755
-
The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors
-
DOI 10.1006/bbrc.1996.0637
-
Inamdar NM, Ahn YI, Alam J. The heme-responsive element of the mouse hemeoxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors. Biochem Biophys Res Commun 1996;221:570-576. (Pubitemid 26153905)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.221
, Issue.3
, pp. 570-576
-
-
Inamdar, N.M.1
Ahn, Y.I.2
Alam, J.3
-
128
-
-
0036775158
-
Heme oxygenase-1: Redox regulation and role in the hepatic response to oxidative stress
-
Bauer M, Bauer I. Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal 2008;4:749-758.
-
(2008)
Antioxid Redox Signal
, vol.4
, pp. 749-758
-
-
Bauer, M.1
Bauer, I.2
-
129
-
-
0027345632
-
Function and regulation of the multidrug resistance gene
-
Chin KV, Pastan I, Gottesman MM. Function and regulation of the multidrug resistance gene. Adv Cancer Res 1993; 60:157-180.
-
(1993)
Adv Cancer Res
, vol.60
, pp. 157-180
-
-
Chin, K.V.1
Pastan, I.2
Gottesman, M.M.3
-
130
-
-
0141481195
-
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols
-
Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML. NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols. Cancer Res 2003; 63:5636-5645.
-
(2003)
Cancer Res
, vol.63
, pp. 5636-5645
-
-
Sekhar, K.R.1
Crooks, P.A.2
Sonar, V.N.3
Friedman, D.B.4
Chan, J.Y.5
Meredith, M.J.6
Starnes, J.H.7
Kelton, K.R.8
Summar, S.R.9
Sasi, S.10
Freeman, M.L.11
-
131
-
-
1642316825
-
Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat
-
Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol 2004;40:585-591.
-
(2004)
J Hepatol
, vol.40
, pp. 585-591
-
-
Denk, G.U.1
Soroka, C.J.2
Takeyama, Y.3
Chen, W.S.4
Schuetz, J.D.5
Boyer, J.L.6
-
132
-
-
22344433760
-
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver
-
Maher JM, Cheng X, Slitt AL, Dieter MZ, Klaassen CD. Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos 2005;33:956-962.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 956-962
-
-
Maher, J.M.1
Cheng, X.2
Slitt, A.L.3
Dieter, M.Z.4
Klaassen, C.D.5
-
133
-
-
33746889956
-
Gene expression profi les induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/ Nrf2 (-/-) mice
-
Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishnan A, Lin W, Reddy B, Chan JY, Kong AN. Gene expression profi les induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/ Nrf2 (-/-) mice. Cancer Lett 2006;243:170-192.
-
(2006)
Cancer Lett
, vol.243
, pp. 170-192
-
-
Hu, R.1
Xu, C.2
Shen, G.3
Jain, M.R.4
Khor, T.O.5
Gopalkrishnan, A.6
Lin, W.7
Reddy, B.8
Chan, J.Y.9
Kong, A.N.10
-
134
-
-
59549099432
-
Disruption of Nrf2 enhances upregulation of NF-kB activity, proinfl ammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury
-
Jin W, Wang H, Yan W, Xu L, Wang X, Zhao X, Yang X, Chen G, Ji Y. Disruption of Nrf2 enhances upregulation of NF-kB activity, proinfl ammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Infl am 2008;725174.
-
(2008)
Mediators Infl Am
, vol.725-774
-
-
Jin, W.1
Wang, H.2
Yan, W.3
Xu, L.4
Wang, X.5
Zhao, X.6
Yang, X.7
Chen, G.8
Ji, Y.9
-
135
-
-
33645530745
-
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
-
Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clinic Invest 2006;116:984-995.
-
(2006)
J Clinic Invest
, vol.116
, pp. 984-995
-
-
Thimmulappa, R.K.1
Lee, H.2
Rangasamy, T.3
Reddy, S.P.4
Yamamoto, M.5
Kensler, T.W.6
Biswal, S.7
-
136
-
-
0035947654
-
Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors
-
Kim YC, Masutani H, Yamaguchi Y, Itoh K, Yamamoto M, Yodoi J. Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors. J Biol Chem 2001;276:18399-18406.
-
(2001)
J Biol Chem
, vol.276
, pp. 18399-18406
-
-
Kim, Y.C.1
Masutani, H.2
Yamaguchi, Y.3
Itoh, K.4
Yamamoto, M.5
Yodoi, J.6
-
139
-
-
27644485874
-
Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview
-
Mariani E, Polidori MC, Cherubini A, Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 2005;827:65-75.
-
(2005)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.827
, pp. 65-75
-
-
Mariani, E.1
Polidori, M.C.2
Cherubini, A.3
Mecocci, P.4
-
140
-
-
54349124273
-
Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?
-
de Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, van Horssen J. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med 2008;45:1375-1383.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 1375-1383
-
-
De Vries, H.E.1
Witte, M.2
Hondius, D.3
Rozemuller, A.J.4
Drukarch, B.5
Hoozemans, J.6
Van Horssen, J.7
-
141
-
-
47949083810
-
The transcription factor Nrf2 is a therapeutic target against brain infl ammation
-
Innamorato NG, Rojo AI, Garcia-Yague AJ, Yamamoto M, de Ceballos ML, Cuadrado A. The transcription factor Nrf2 is a therapeutic target against brain infl ammation. J Immunol 2008;181:680-689.
-
(2008)
J Immunol
, vol.181
, pp. 680-689
-
-
Innamorato, N.G.1
Rojo, A.I.2
Garcia-Yague, A.J.3
Yamamoto, M.4
De Ceballos, M.L.5
Cuadrado, A.6
-
142
-
-
67049100713
-
Role of microglial redox balance in modulation of neuroinfl amma-tion
-
Innamorato NG, Lastres-Becker I, Cuadrado A. Role of microglial redox balance in modulation of neuroinfl amma-tion. Curr Opin Neurol 2009;22:308-314.
-
(2009)
Curr Opin Neurol
, vol.22
, pp. 308-314
-
-
Innamorato, N.G.1
Lastres-Becker, I.2
Cuadrado, A.3
-
143
-
-
3042857903
-
Alzheimer's disease
-
Cummings JL. Alzheimer's disease. N Engl J Med 2004; 351:56-67.
-
(2004)
N Engl J Med
, vol.351
, pp. 56-67
-
-
Cummings, J.L.1
-
144
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer's disease
-
Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 1997;23:134-147.
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
145
-
-
34347332411
-
The role of metals in the etiology of Alzheimer's disease
-
Shcherbatykh I, Carpenter DO. The role of metals in the etiology of Alzheimer's disease. J Alzheimers Dis 2007;11: 191-205.
-
(2007)
J Alzheimers Dis
, vol.11
, pp. 191-205
-
-
Shcherbatykh, I.1
Carpenter, D.O.2
-
146
-
-
33947644871
-
Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: Insights into mechanism of neurodegeneration from redox proteomics
-
Sultana R, Perluigi M, Butterfi eld DA. Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics. Antioxid Redox Signal 2006;8: 2021-2037.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 2021-2037
-
-
Sultana, R.1
Perluigi, M.2
Butterfield, D.A.3
-
147
-
-
33646103133
-
Increased brain levels of 4-hydroxy-2-nonel glutathione conjugates in severe Alzheimer's disease
-
Volke W, Sicilia T, Pahler A, Gsell W, Tatschner T, Jellinger K, Leblhuber F, Riederer P, Lutz WK, Gotz ME. Increased brain levels of 4-hydroxy-2-nonel glutathione conjugates in severe Alzheimer's disease. Neurochem Int 2006;48:679-686.
-
(2006)
Neurochem Int
, vol.48
, pp. 679-686
-
-
Volke, W.1
Sicilia, T.2
Pahler, A.3
Gsell, W.4
Tatschner, T.5
Jellinger, K.6
Leblhuber, F.7
Riederer, P.8
Lutz, W.K.9
Gotz, M.E.10
-
148
-
-
0028152717
-
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
-
Mecocci P, MacGarvey U, Beal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 1994;36:747-751.
-
(1994)
Ann Neurol
, vol.36
, pp. 747-751
-
-
Mecocci, P.1
MacGarvey, U.2
Beal, M.F.3
-
149
-
-
18844462415
-
Increased oxidative stress in nuclear and mitochondrial DNA in Alzheimer's disease
-
Wang J, Xion S, Xie C, Markesbery WR, Lovell MA. Increased oxidative stress in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem 2005;93:953-962.
-
(2005)
J Neurochem
, vol.93
, pp. 953-962
-
-
Wang, J.1
Xion, S.2
Xie, C.3
Markesbery, W.R.4
Lovell, M.A.5
-
150
-
-
33846073880
-
Expression of Nrf2 in neurodegenerative diseases
-
Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL. Expression of Nrf2 in neurodegenerative diseases. J Neuro pathol Exp Neurol 2007;66:75-85.
-
(2007)
J Neuro Pathol Exp Neurol
, vol.66
, pp. 75-85
-
-
Ramsey, C.P.1
Glass, C.A.2
Montgomery, M.B.3
Lindl, K.A.4
Ritson, G.P.5
Chia, L.A.6
Hamilton, R.L.7
Chu, C.T.8
Jordan-Sciutto, K.L.9
-
151
-
-
9144257938
-
DJ-1 colocalizes with tau inclusions: A link between Parkinsonism and dementia
-
Rizzu P, Hinkle DA, Zhukareva V, Bonifati V, Severijnin LA, Martinez D, Ravid R, Kamphorst W, Eberwine JH, Lee VM, Trojanowski JQ, Heutink P. DJ-1 colocalizes with tau inclusions: a link between Parkinsonism and dementia. Ann Neurol 2004;55:113-118.
-
(2004)
Ann Neurol
, vol.55
, pp. 113-118
-
-
Rizzu, P.1
Hinkle, D.A.2
Zhukareva, V.3
Bonifati, V.4
Severijnin, L.A.5
Martinez, D.6
Ravid, R.7
Kamphorst, W.8
Eberwine, J.H.9
Lee, V.M.10
Trojanowski, J.Q.11
Heutink, P.12
-
152
-
-
31344464179
-
The oxidation state of DJ-1 regulates its chaperon activity towards alpha-synuclein
-
Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL. The oxidation state of DJ-1 regulates its chaperon activity towards alpha-synuclein. J Mol Biol 2006;356:1036-1048.
-
(2006)
J Mol Biol
, vol.356
, pp. 1036-1048
-
-
Zhou, W.1
Zhu, M.2
Wilson, M.A.3
Petsko, G.A.4
Fink, A.L.5
-
153
-
-
34548829892
-
DJ-1 (PARK7) is associated with 3R and 4R tau neuronal glial inclusions in neurodegenerative disorders
-
Kumaran R, Kingsbury A, Coulter I, Lashley T, Williams D, de Silva R, Mann D, Revesz T, Lees A, Bandopadhyay R. DJ-1 (PARK7) is associated with 3R and 4R tau neuronal glial inclusions in neurodegenerative disorders. Neurobiol Dis 2007;28:122-132.
-
(2007)
Neurobiol Dis
, vol.28
, pp. 122-132
-
-
Kumaran, R.1
Kingsbury, A.2
Coulter, I.3
Lashley, T.4
Williams, D.5
De Silva, R.6
Mann, D.7
Revesz, T.8
Lees, A.9
Bandopadhyay, R.10
-
154
-
-
33750052885
-
DJ-1, a cancer-and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
-
Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP. DJ-1, a cancer-and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci USA 2006;103:15091-15096.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 15091-15096
-
-
Clements, C.M.1
McNally, R.S.2
Conti, B.J.3
Mak, T.W.4
Ting, J.P.5
-
156
-
-
38449086141
-
Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway
-
Wruck CJ, Claussen M, Fuhrmann G, Römer L, Schulz A, Pufe T, Waetzig V, Peipp M, Herdegen T, Götz ME. Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. J Neural Transm Suppl 2007;72:57-67.
-
(2007)
J Neural Transm Suppl
, vol.72
, pp. 57-67
-
-
Wruck, C.J.1
Claussen, M.2
Fuhrmann, G.3
Römer, L.4
Schulz, A.5
Pufe, T.6
Waetzig, V.7
Peipp, M.8
Herdegen, T.9
Götz, M.E.10
-
157
-
-
35148835788
-
NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells
-
Li HY, Zhong YF, Wu SY, Shi N. NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells. Chem Res Toxicol 2007;20: 1242-1251.
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 1242-1251
-
-
Li, H.Y.1
Zhong, Y.F.2
Wu, S.Y.3
Shi, N.4
-
158
-
-
34147147998
-
Huntington's Disease
-
Walker FO. Huntington's Disease. Semin Neurol 2007;27: 143-150.
-
(2007)
Semin Neurol
, vol.27
, pp. 143-150
-
-
Walker, F.O.1
-
159
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
Scherzinger E, Lurz R, Turmaine M, Mangiarini L, Hollenbach B, Hasenbank R, Bates GP, Davies SW, Lehrach H, Wanker EE. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo . Cell 1997;90:549-558.
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
160
-
-
0025078573
-
Mtochondrial function and parental sex effect in Huntington's disease
-
Mann VM, Cooper JM, Javoy-Agid F, Agid Y, Jenner P, Schapira AH. Mtochondrial function and parental sex effect in Huntington's disease. Lancet 1990;336:749.
-
(1990)
Lancet
, vol.336
, pp. 749
-
-
Mann, V.M.1
Cooper, J.M.2
Javoy-Agid, F.3
Agid, Y.4
Jenner, P.5
Schapira, A.H.6
-
161
-
-
0029875381
-
Mitochondrial defect in Huntington's disease caudate nucleus
-
Gu M, Gash MT, Mann VM, Javoy-Agid F, Cooper JM, Schapira AH. Mitochondrial defect in Huntington's disease caudate nucleus. Ann Neurol 1996;39:385-389.
-
(1996)
Ann Neurol
, vol.39
, pp. 385-389
-
-
Gu, M.1
Gash, M.T.2
Mann, V.M.3
Javoy-Agid, F.4
Cooper, J.M.5
Schapira, A.H.6
-
162
-
-
0034660457
-
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease
-
Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 2000; 20:4389-4397.
-
(2000)
J Neurosci
, vol.20
, pp. 4389-4397
-
-
Ferrante, R.J.1
Andreassen, O.A.2
Jenkins, B.G.3
Dedeoglu, A.4
Kuemmerle, S.5
Kubilus, J.K.6
Kaddurah-Daouk, R.7
Hersch, S.M.8
Beal, M.F.9
-
163
-
-
0034743672
-
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease
-
Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis 2001;8:479-491.
-
(2001)
Neurobiol Dis
, vol.8
, pp. 479-491
-
-
Andreassen, O.A.1
Dedeoglu, A.2
Ferrante, R.J.3
Jenkins, B.G.4
Ferrante, K.L.5
Thomas, M.6
Friedlich, A.7
Browne, S.E.8
Schilling, G.9
Borchelt, D.R.10
Hersch, S.M.11
Ross, C.A.12
Beal, M.F.13
-
164
-
-
33644927838
-
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG
-
Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, Zaleta A, Kaneko Y, Jenkins B, Hevelone N, Zhang H, Yu H, Schoenfeld D, Ferrante R, Rosas HD. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology 2006;66:250-252.
-
(2006)
Neurology
, vol.66
, pp. 250-252
-
-
Hersch, S.M.1
Gevorkian, S.2
Marder, K.3
Moskowitz, C.4
Feigin, A.5
Cox, M.6
Como, P.7
Zimmerman, C.8
Lin, M.9
Zhang, L.10
Ulug, A.M.11
Beal, M.F.12
Matson, W.13
Bogdanov, M.14
Ebbel, E.15
Zaleta, A.16
Kaneko, Y.17
Jenkins, B.18
Hevelone, N.19
Zhang, H.20
Yu, H.21
Schoenfeld, D.22
Ferrante, R.23
Rosas, H.D.24
more..
-
165
-
-
57049133956
-
Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
-
van Roon-Mom WM, Pepers BA,'t Hoen PA, Verwijmeren CA, den Dunnen JT, Dorsman JC, van Ommen GB. Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease. BMC Mol Biol 2008;9:84-96.
-
(2008)
BMC Mol Biol
, vol.9
, pp. 84-96
-
-
Van Roon-Mom, W.M.1
Pepers, B.A.2
Hoen, P.A.3
Verwijmeren, C.A.4
Den Dunnen, J.T.5
Dorsman, J.C.6
Van Ommen, G.B.7
-
166
-
-
52049086965
-
Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats
-
Yan W, Wang HD, Zhu L, Feng XM, Qiao L, Jin W, Tang K. Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain Inj 2008; 22:802-810.
-
(2008)
Brain Inj
, vol.22
, pp. 802-810
-
-
Yan, W.1
Wang, H.D.2
Zhu, L.3
Feng, X.M.4
Qiao, L.5
Jin, W.6
Tang, K.7
-
167
-
-
62249089498
-
Targeting the redox sensitive Nrf2-Keap-1 defense pathway in cardiovascular disease: Protection afforded by dietary isofl avones
-
Manne GE, Bonacasa B, Ishii T, Siow RC. Targeting the redox sensitive Nrf2-Keap-1 defense pathway in cardiovascular disease: protection afforded by dietary isofl avones. Curr Opin Pharmacol 2009;9:139-145.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 139-145
-
-
Manne, G.E.1
Bonacasa, B.2
Ishii, T.3
Siow, R.C.4
-
168
-
-
56049102574
-
Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Infl uence of low glucose
-
Langston W, Circu ML, Aw TY. Insulin stimulation of gamma- glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: infl uence of low glucose. Free Radic Biol Med 2008;45:1591-1599.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 1591-1599
-
-
Langston, W.1
Circu, M.L.2
Aw, T.Y.3
-
169
-
-
62349116866
-
Vascular NAD(P)H oxidase activation in diabetes: A double-edged sword in redox signaling
-
Gao L, Mann GE. Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signaling. Cardiovasc Res 2009;82:9-20.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 9-20
-
-
Gao, L.1
Mann, G.E.2
-
170
-
-
73949142348
-
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinfl ammatory state
-
Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, Evans PC. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinfl ammatory state. Arterioscler Thromb Vasc Biol 2009;29:1851-1857.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1851-1857
-
-
Zakkar, M.1
Van Der Heiden, K.2
Luong Le, A.3
Chaudhury, H.4
Cuhlmann, S.5
Hamdulay, S.S.6
Krams, R.7
Edirisinghe, I.8
Rahman, I.9
Carlsen, H.10
Haskard, D.O.11
Mason, J.C.12
Evans, P.C.13
-
171
-
-
42449111723
-
NF-E2 related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high fat diet
-
Tanaka Y, Aleksunes LM, Yeager RL, Gyamfi MA, Esterly N, Guo GL, Klaassen CD. NF-E2 related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high fat diet. J Pharmacol Exp Ther 2008;325:655-664.
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 655-664
-
-
Tanaka, Y.1
Aleksunes, L.M.2
Yeager, R.L.3
Gyamfi, M.A.4
Esterly, N.5
Guo, G.L.6
Klaassen, C.D.7
-
172
-
-
0036007313
-
Role of Nrf2 in protection against hyperoxic lung injury in mice
-
Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR. Role of Nrf2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 2002;26:175-182.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 175-182
-
-
Cho, H.Y.1
Jedlicka, A.E.2
Reddy, S.P.3
Kensler, T.W.4
Yamamoto, M.5
Zhang, L.Y.6
Kleeberger, S.R.7
-
173
-
-
9444249870
-
The transcription factor NRF2 protects against pulmonary fi brosis
-
Cho HY, Reddy SP, Yamamoto M, Kleeberger SR. The transcription factor NRF2 protects against pulmonary fi brosis. FASEB J 2004;18:1258-1260.
-
(2004)
FASEB J
, vol.18
, pp. 1258-1260
-
-
Cho, H.Y.1
Reddy, S.P.2
Yamamoto, M.3
Kleeberger, S.R.4
-
174
-
-
22344438250
-
Disruption of Nrf2 enhances susceptibility to severe airway infl ammation and asthma in mice
-
Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway infl ammation and asthma in mice. J Exp Med 2005;202:47-59.
-
(2005)
J Exp Med
, vol.202
, pp. 47-59
-
-
Rangasamy, T.1
Guo, J.2
Mitzner, W.A.3
Roman, J.4
Singh, A.5
Fryer, A.D.6
Yamamoto, M.7
Kensler, T.W.8
Tuder, R.M.9
Georas, S.N.10
Biswal, S.11
-
175
-
-
0032874845
-
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
-
Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 1999;31: 273-300.
-
(1999)
Free Radic Res
, vol.31
, pp. 273-300
-
-
Hayes, J.D.1
McLellan, L.I.2
-
176
-
-
0037077204
-
Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells: Involvement of AP-1/ARE and Fra-1
-
Jardine H, MacNee W, Donaldson K, Rahman I. Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells: involvement of AP-1/ARE and Fra-1. J Biol Chem 2002;277:21158-21166.
-
(2002)
J Biol Chem
, vol.277
, pp. 21158-21166
-
-
Jardine, H.1
MacNee, W.2
Donaldson, K.3
Rahman, I.4
-
177
-
-
11344292584
-
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins
-
Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X, Meredith MJ, Arteaga CL, Freeman ML. Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins. Free Radic Biol Med 2005; 38:375-387.
-
(2005)
Free Radic Biol Med
, vol.38
, pp. 375-387
-
-
Bakin, A.V.1
Stourman, N.V.2
Sekhar, K.R.3
Rinehart, C.4
Yan, X.5
Meredith, M.J.6
Arteaga, C.L.7
Freeman, M.L.8
-
178
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004;114:1248-1259.
-
(2004)
J Clin Invest
, vol.114
, pp. 1248-1259
-
-
Rangasamy, T.1
Cho, C.Y.2
Thimmulappa, R.K.3
Zhen, L.4
Srisuma, S.S.5
Kensler, T.W.6
Yamamoto, M.7
Petrache, I.8
Tuder, R.M.9
Biswal, S.10
-
179
-
-
29244473882
-
Nrf2-defi cient mice are highly susceptible to cigarette smoke-induced emphysema
-
Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K. Nrf2-defi cient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells 2005;10:1113-1125.
-
(2005)
Genes Cells
, vol.10
, pp. 1113-1125
-
-
Iizuka, T.1
Ishii, Y.2
Itoh, K.3
Kiwamoto, T.4
Kimura, T.5
Matsuno, Y.6
Morishima, Y.7
Hegab, A.E.8
Homma, S.9
Nomura, A.10
Sakamoto, T.11
Shimura, M.12
Yoshida, A.13
Yamamoto, M.14
Sekizawa, K.15
-
180
-
-
58549105575
-
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
-
Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, SpornMB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci 2009;106:250-255.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 250-255
-
-
Sussan, T.E.1
Rangasamy, T.2
Blake, D.J.3
Malhotra, D.4
El-Haddad, H.5
Bedja, D.6
Yates, M.S.7
Kombairaju, P.8
Yamamoto, M.9
Liby, K.T.10
Spornmb Gabrielson, K.L.11
Champion, H.C.12
Tuder, R.M.13
Kensler, T.W.14
Biswal, S.15
-
181
-
-
0036723948
-
Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers'lung
-
Harju T, Kaarteenaho-Wiik R, Soini Y, Sormunen R, Kinnula VL. Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers'lung. Am J Respir Crit Care Med 2002;166:754-759.
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 754-759
-
-
Harju, T.1
Kaarteenaho-Wiik, R.2
Soini, Y.3
Sormunen, R.4
Kinnula, V.L.5
-
182
-
-
51849129227
-
Decline in Nrf2 regulated antioxidants in COPD lungs due toloss of its positive regulator DJ-1
-
Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. Decline in Nrf2 regulated antioxidants in COPD lungs due toloss of its positive regulator DJ-1. Am J Respir Crit Care Med 2008;178:592-604.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 592-604
-
-
Malhotra, D.1
Thimmulappa, R.2
Navas-Acien, A.3
Sandford, A.4
Elliott, M.5
Singh, A.6
Chen, L.7
Zhuang, X.8
Hogg, J.9
Pare, P.10
Tuder, R.M.11
Biswal, S.12
-
183
-
-
53649099660
-
Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
-
Goven D, Boutten A, Lecon-Malas V, Marchal-Somme J, Amara N, Crestani B, Fournier M, Leseche G, Soler P, Boczkowski J, Bonay M. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax 2008;63:916-924.
-
(2008)
Thorax
, vol.63
, pp. 916-924
-
-
Goven, D.1
Boutten, A.2
Lecon-Malas, V.3
Marchal-Somme, J.4
Amara, N.5
Crestani, B.6
Fournier, M.7
Leseche, G.8
Soler, P.9
Boczkowski, J.10
Bonay, M.11
-
184
-
-
57349151482
-
Downregulated NF-E2-related Factor 2 in pulmonary macrophages of aged smokers and COPD patients
-
Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M. Downregulated NF-E2-related Factor 2 in pulmonary macrophages of aged smokers and COPD patients. Am J Respir Cell Mol Biol 2008;39:673-682.
-
(2008)
Am J Respir Cell Mol Biol
, vol.39
, pp. 673-682
-
-
Suzuki, M.1
Betsuyaku, T.2
Ito, Y.3
Nagai, K.4
Nasuhara, Y.5
Kaga, K.6
Kondo, S.7
Nishimura, M.8
-
186
-
-
13244289773
-
Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity
-
Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal 2005;7:32-41.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 32-41
-
-
Biswas, S.K.1
McClure, D.2
Jimenez, L.A.3
Megson, I.L.4
Rahman, I.5
-
187
-
-
41549108838
-
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
-
Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008;294:L478-L488.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
-
-
Kode, A.1
Rajendrasozhan, S.2
Caito, S.3
Yang, S.R.4
Megson, I.L.5
Rahman, I.6
-
188
-
-
58449116694
-
Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease
-
Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, Polack FP, Kleeberger SR. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med 2009;179:138-150.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 138-150
-
-
Cho, H.Y.1
Imani, F.2
Miller-Degraff, L.3
Walters, D.4
Melendi, G.A.5
Yamamoto, M.6
Polack, F.P.7
Kleeberger, S.R.8
-
189
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008; 29:1235-1243 .
-
(2008)
Carcinogenesis
, vol.29
, pp. 1235-1243
-
-
Wang, X.J.1
Sun, Z.2
Villeneuve, N.F.3
Zhang, S.4
Zhao, F.5
Li, Y.6
Chen, W.7
Yi, X.8
Zheng, W.9
Wondrak, G.T.10
Wong, P.K.11
Zhang, D.D.12
-
190
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD. Dual roles of Nrf2 in cancer. Pharmacol Res 2008;58:262-270.
-
(2008)
Pharmacol Res
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
-
191
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 2006;21:689-700.
-
(2006)
Mol Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
Nakamura, Y.4
Scharlock, M.5
Ohtsuji, M.6
Kang, M.I.7
Kobayashi, A.8
Yokoyama, S.9
Yamamoto, M.10
-
192
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, Shibata T, Yamamoto M, Hirohashi S. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 2008;68:1303-1309.
-
(2008)
Cancer Res
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
Shibata, T.11
Yamamoto, M.12
Hirohashi, S.13
-
193
-
-
70449577142
-
Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells
-
Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, Shi J, Zhang H, Jia X, Du Y, Zhang J. Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. PLoS One 2009;4:e7538.
-
(2009)
PLoS One
, vol.4
-
-
Wang, K.1
Fang, H.2
Xiao, D.3
Zhu, X.4
He, M.5
Pan, X.6
Shi, J.7
Zhang, H.8
Jia, X.9
Du, Y.10
Zhang, J.11
-
194
-
-
0026021362
-
Production of large amounts of hydrogen peroxide by human tumor cells
-
Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991; 51:794-798.
-
(1991)
Cancer Res
, vol.51
, pp. 794-798
-
-
Szatrowski, T.P.1
Nathan, C.F.2
-
195
-
-
0034699513
-
Superoxide dismutase as a target for the selective killing of cancer cells
-
Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000;407:390-395.
-
(2000)
Nature
, vol.407
, pp. 390-395
-
-
Huang, P.1
Feng, L.2
Oldham, E.A.3
Keating, M.J.4
Plunkett, W.5
-
196
-
-
77951557888
-
The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
-
Johnson DA, Amirahmadi S, Ward C, Fabry Z, Johnson JA. The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicol Sci 2010;114:237-246.
-
(2010)
Toxicol Sci
, vol.114
, pp. 237-246
-
-
Johnson, D.A.1
Amirahmadi, S.2
Ward, C.3
Fabry, Z.4
Johnson, J.A.5
-
197
-
-
77956624172
-
Nrf2 inhibits the maturation of murine dendritic cells by Ragweed extract
-
doi:10.1165/rcmb.2008-0438OC
-
Rangasamy T, Williams MA, Bauer S, Trush MA, Emo J, Georas SN, Biswal S. Nrf2 inhibits the maturation of murine dendritic cells by Ragweed extract. Am J Respir Cell Mol Biol 2009:doi:10.1165/rcmb.2008-0438OC.
-
(2009)
Am J Respir Cell Mol Biol
-
-
Rangasamy, T.1
Williams, M.A.2
Bauer, S.3
Trush, M.A.4
Emo, J.5
Georas, S.N.6
Biswal, S.7
-
198
-
-
33644652410
-
Role of the Nrf2-mediated signaling pathway as a negative regulator of infl ammation: Implications for the impact of particulate pollutants on asthma
-
Li N, Nel AE. Role of the Nrf2-mediated signaling pathway as a negative regulator of infl ammation: implications for the impact of particulate pollutants on asthma. Antioxid Redox Signal 2006;8:88-98.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 88-98
-
-
Li, N.1
Nel, A.E.2
-
199
-
-
49049106335
-
Activation of Nrf2 in defense against cadmium-induced oxidative stress
-
He X, Chen MG, Ma Q. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem Res Toxicol 2008;21:1375-1383.
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1375-1383
-
-
He, X.1
Chen, M.G.2
Ma, Q.3
-
200
-
-
34447105955
-
The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: Comparison with the toxic effect on NAD(P)H:quinone reductase
-
Casalino E, Calzaretti G, Landriscina M, Sblano C, Fabiano A, Landriscina C. The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase. Toxicology 2007;237:24-34.
-
(2007)
Toxicology
, vol.237
, pp. 24-34
-
-
Casalino, E.1
Calzaretti, G.2
Landriscina, M.3
Sblano, C.4
Fabiano, A.5
Landriscina, C.6
-
201
-
-
33748282175
-
Chromium (VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells
-
O'Hara KA, Nemec AA, Alam J, Klei LR, Mossman BT, Barchowsky A. Chromium (VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells. J Cell Physiol 2006;209:113-121.
-
(2006)
J Cell Physiol
, vol.209
, pp. 113-121
-
-
O'Hara, K.A.1
Nemec, A.A.2
Alam, J.3
Klei, L.R.4
Mossman, B.T.5
Barchowsky, A.6
-
202
-
-
0034894722
-
Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: Role of mitochondrial oxidant stress
-
Knight TR, Kurtz A, Bajit ML, Hinson JA, Jaeschke H. Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol Sci 2001;62:212-220.
-
(2001)
Toxicol Sci
, vol.62
, pp. 212-220
-
-
Knight, T.R.1
Kurtz, A.2
Bajit, M.L.3
Hinson, J.A.4
Jaeschke, H.5
-
204
-
-
0043135016
-
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotox-icity
-
Jaeschke H, Knight TR, Bajit ML. The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotox-icity. Toxicol Lett 2003;144:279-288.
-
(2003)
Toxicol Lett
, vol.144
, pp. 279-288
-
-
Jaeschke, H.1
Knight, T.R.2
Bajit, M.L.3
-
205
-
-
0035836698
-
An important function of Nrf2 in combating oxidative stress: Detoxifi cation of acetaminophen
-
Chan K, Han XD, Kan YW. An important function of Nrf2 in combating oxidative stress: detoxifi cation of acetaminophen. Proc Natl Acad Sci 2001;98:4611-4616.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
206
-
-
47849083585
-
Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
-
Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 2008;659:31-39.
-
(2008)
Mutat Res
, vol.659
, pp. 31-39
-
-
Osburn, W.O.1
Kensler, T.W.2
-
207
-
-
0035853101
-
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
-
Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA 2001;98:3404-3409.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3404-3409
-
-
Dinkova-Kostova, A.T.1
Massiah, M.A.2
Bozak, R.E.3
Hicks, R.J.4
Talalay, P.5
-
208
-
-
0036316905
-
Carnosol, an antioxidant in rosemary, suppress inducible inducible nitric oxide synthase through down regulating NF-κ B in mouse macrophage
-
Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppress inducible inducible nitric oxide synthase through down regulating NF-κ B in mouse macrophage. Carcinogenesis 2002;23:983-999.
-
(2002)
Carcinogenesis
, vol.23
, pp. 983-999
-
-
Lo, A.H.1
Liang, Y.C.2
Lin-Shiau, S.Y.3
Ho, C.T.4
Lin, J.K.5
-
209
-
-
0037569694
-
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the anti-oxidant-responsive element
-
Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the anti-oxidant-responsive element. Biochem J 2003;371:887-895.
-
(2003)
Biochem J
, vol.371
, pp. 887-895
-
-
Balogun, E.1
Hoque, M.2
Gong, P.3
Killeen, E.4
Green, C.J.5
Foresti, R.6
Alam, J.7
Motterlini, R.8
-
210
-
-
46949104416
-
Dietary curcumin modulates transcriptional regulators of phase i and phase II enzymes in benzo[a]pyrene-treated mice: Mechanism of its anti-initiating action
-
Garg R, Gupta S, Maru GB. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis 2008;29:1022-1032.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1022-1032
-
-
Garg, R.1
Gupta, S.2
Maru, G.B.3
-
211
-
-
67649670106
-
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
-
Yang C, Zhang X, Fan H, Liu Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 2009;1282:133-141.
-
(2009)
Brain Res
, vol.1282
, pp. 133-141
-
-
Yang, C.1
Zhang, X.2
Fan, H.3
Liu, Y.4
-
212
-
-
59249104565
-
Curcumin protects retinal cells from light-and oxidant stress-induced cell death
-
Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, Wicker L, Kasus-Jacobi A, Elliott MH, Rao CV, Anderson RE. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med 2009;461: 672-679.
-
(2009)
Free Radic Biol Med
, vol.461
, pp. 672-679
-
-
Mandal, M.N.1
Patlolla, J.M.2
Zheng, L.3
Agbaga, M.P.4
Tran, J.T.5
Wicker, L.6
Kasus-Jacobi, A.7
Elliott, M.H.8
Rao, C.V.9
Anderson, R.E.10
-
213
-
-
63049112375
-
Antioxidant therapeutic advances in COPD
-
Rahman I. Antioxidant therapeutic advances in COPD. Ther Adv Respir Dis 2008;2:351-374.
-
(2008)
Ther Adv Respir Dis
, vol.2
, pp. 351-374
-
-
Rahman, I.1
-
214
-
-
0345074085
-
Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity
-
Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 2003;92:33-38.
-
(2003)
Pharmacol Toxicol
, vol.92
, pp. 33-38
-
-
Iqbal, M.1
Sharma, S.D.2
Okazaki, Y.3
Fujisawa, M.4
Okada, S.5
-
215
-
-
0011985195
-
Protection against cancer by plant phenylpropenoids: Induction of mammalian anticarcino-genic enzymes
-
Dinkova-Kostova AT. Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcino-genic enzymes. Mini Rev Med Chem 2002;2:595-610.
-
(2002)
Mini Rev Med Chem
, vol.2
, pp. 595-610
-
-
Dinkova-Kostova, A.T.1
-
216
-
-
1542335553
-
Regulation of heme oxygen-ase-1 expression through the phosphatidylinositol 3-kinase/ Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
-
Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, Galarreta CM, Cuadrado A. Regulation of heme oxygen-ase-1 expression through the phosphatidylinositol 3-kinase/ Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 2004;279:8919-8929.
-
(2004)
J Biol Chem
, vol.279
, pp. 8919-8929
-
-
Martin, D.1
Rojo, A.I.2
Salinas, M.3
Diaz, R.4
Gallardo, G.5
Alam, J.6
Galarreta, C.M.7
Cuadrado, A.8
-
217
-
-
34247606510
-
Molecular basis for chemo-prevention by sulforaphane: A comprehensive review
-
Juge N, Mithen RF, Traka M. Molecular basis for chemo-prevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 2007;64:1105-1127.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 1105-1127
-
-
Juge, N.1
Mithen, R.F.2
Traka, M.3
-
218
-
-
0037293980
-
Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines
-
Kassie F, Sundermann VM, Edenharder R, Platt KL, Darroudi F, Lhoste E, Humbolt C, Muckel E, Uhl M, Kundi M, Knasmuller S. Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines. Mutat Res 2003;523-524:183-192.
-
(2003)
Mutat Res
, vol.523-524
, pp. 183-192
-
-
Kassie, F.1
Sundermann, V.M.2
Edenharder, R.3
Platt, K.L.4
Darroudi, F.5
Lhoste, E.6
Humbolt, C.7
Muckel, E.8
Uhl, M.9
Kundi, M.10
Knasmuller, S.11
-
219
-
-
5344220933
-
Induction of detoxifying enzymes by Garlic organosulphur compounds through transcription factor. Nrf2: Effect of chemical structure and stress signals
-
Chen C, Pung D, Leong V, Hebbar V, Shen G, Nair S, Li W, Kong AN. Induction of detoxifying enzymes by Garlic organosulphur compounds through transcription factor. Nrf2: effect of chemical structure and stress signals. Free Rad Biol Med 2004;37:1578-1590.
-
(2004)
Free Rad Biol Med
, vol.37
, pp. 1578-1590
-
-
Chen, C.1
Pung, D.2
Leong, V.3
Hebbar, V.4
Shen, G.5
Nair, S.6
Li, W.7
Kong, A.N.8
-
220
-
-
34247282872
-
Action of Nrf2 and Keap1 in ARE-mediated NQO-1 expression by quercetin
-
Tanigawa S, Fujii M, Hou DX. Action of Nrf2 and Keap1 in ARE-mediated NQO-1 expression by quercetin. Free Radic Biol Med 2007;42:1690-1703.
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 1690-1703
-
-
Tanigawa, S.1
Fujii, M.2
Hou, D.X.3
-
221
-
-
37649023810
-
Upregulation of heme oxygenase-1 by brazilin via the phosphotidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury
-
Choi BM, Kim BR. Upregulation of heme oxygenase-1 by brazilin via the phosphotidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. Euro J Pharma 2008;580:12-18.
-
(2008)
Euro J Pharma
, vol.580
, pp. 12-18
-
-
Choi, B.M.1
Kim, B.R.2
-
222
-
-
54249119465
-
Simvastatin activates Keap1/Nrf2 signaling in rat liver
-
Habeos IG, Ziros PG, Chartoumpekis D, Psyrogiannis A, Kyriazopoulou V, Papavassiliou AG. Simvastatin activates Keap1/Nrf2 signaling in rat liver. J Mol Med 2008;86: 1279-1285.
-
(2008)
J Mol Med
, vol.86
, pp. 1279-1285
-
-
Habeos, I.G.1
Ziros, P.G.2
Chartoumpekis, D.3
Psyrogiannis, A.4
Kyriazopoulou, V.5
Papavassiliou, A.G.6
-
223
-
-
77749339881
-
Nrf2 regulates microglial dynamics and neuroinfl ammation in experimental Parkinson's disease
-
Rojo AI, Innamorato NG, Martín-Moreno AM, De Ceballos ML, Yamamoto M, Cuadrado A. Nrf2 regulates microglial dynamics and neuroinfl ammation in experimental Parkinson's disease. Glia 2010;58:588-598.
-
(2010)
Glia
, vol.58
, pp. 588-598
-
-
Rojo, A.I.1
Innamorato, N.G.2
Martín-Moreno, A.M.3
De Ceballos, M.L.4
Yamamoto, M.5
Cuadrado, A.6
-
224
-
-
70349333698
-
The Nrf2-ARE cytoprotective pathway in astrocytes
-
Vargas MR, Johnson JA. The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Rev Mol Med 2009;11:e17.
-
(2009)
Expert Rev Mol Med
, vol.11
-
-
Vargas, M.R.1
Johnson, J.A.2
-
225
-
-
59849088818
-
Role of Nrf2 in protection against traumatic brain injury in mice
-
Jin W, Wang H, Yan W, Zhu L, Hu Z, Ding Y, Tang K. Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma 2009;26:31-39.
-
(2009)
J Neurotrauma
, vol.26
, pp. 31-39
-
-
Jin, W.1
Wang, H.2
Yan, W.3
Zhu, L.4
Hu, Z.5
Ding, Y.6
Tang, K.7
-
226
-
-
67651124846
-
Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
-
Liu M, Grigoryev DN, Crow MT, Haas M, Yamamoto M, Reddy SP, Rabb H. Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int 2009;76:277-285.
-
(2009)
Kidney Int
, vol.76
, pp. 277-285
-
-
Liu, M.1
Grigoryev, D.N.2
Crow, M.T.3
Haas, M.4
Yamamoto, M.5
Reddy, S.P.6
Rabb, H.7
-
227
-
-
62249089498
-
Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: Protection afforded by dietary isofl avones
-
Mann GE, Bonacasa B, Ishii T, Siow RC. Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isofl avones. Curr Opin Pharmacol 2009;9:139-145.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 139-145
-
-
Mann, G.E.1
Bonacasa, B.2
Ishii, T.3
Siow, R.C.4
-
228
-
-
59649088602
-
Key transcriptional regulators of the vasoprotective effects of shear stress
-
Boon RA, Horrevoets AJ. Key transcriptional regulators of the vasoprotective effects of shear stress. Hamostaseologie 2009;29:39-40.
-
(2009)
Hamostaseologie
, vol.29
, pp. 39-40
-
-
Boon, R.A.1
Horrevoets, A.J.2
-
229
-
-
72549115279
-
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: The role of Nrf2-regulated proteasomal activity
-
Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S. Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. Am J Respir Crit Care Med 2009;180:1196-207.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 1196-207
-
-
Malhotra, D.1
Thimmulappa, R.2
Vij, N.3
Navas-Acien, A.4
Sussan, T.5
Merali, S.6
Zhang, L.7
Kelsen, S.G.8
Myers, A.9
Wise, R.10
Tuder, R.11
Biswal, S.12
-
230
-
-
70449723401
-
Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-defi cient mice
-
Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensle TW, Hassoun PM, Kleeberger SR, Reddy SP. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-defi cient mice. J Immunol 2009;183:4601-4608.
-
(2009)
J Immunol
, vol.183
, pp. 4601-4608
-
-
Reddy, N.M.1
Suryanarayana, V.2
Kalvakolanu, D.V.3
Yamamoto, M.4
Kensle, T.W.5
Hassoun, P.M.6
Kleeberger, S.R.7
Reddy, S.P.8
-
231
-
-
72449174784
-
The triterpenoid CDDO limits infl ammation in preclinical models of cystic fi brosis lung disease
-
Nichols DP, Ziady AG, Shank SL, Eastman JF, Davis PB. The triterpenoid CDDO limits infl ammation in preclinical models of cystic fi brosis lung disease. Am J Physiol Lung Cell Mol Physiol 2009;297:828-836.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
, pp. 828-836
-
-
Nichols, D.P.1
Ziady, A.G.2
Shank, S.L.3
Eastman, J.F.4
Davis, P.B.5
-
232
-
-
59149098593
-
Sulforaphane protects against cytokine-and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway
-
Song MY, Kim EK, Moon WS, Park JW, Kim HJ, So HS, Park R, Kwon KB, Park BH. Sulforaphane protects against cytokine-and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Toxicol Appl Pharmacol 2009;235:57-67.
-
(2009)
Toxicol Appl Pharmacol
, vol.235
, pp. 57-67
-
-
Song, M.Y.1
Kim, E.K.2
Moon, W.S.3
Park, J.W.4
Kim, H.J.5
So, H.S.6
Park, R.7
Kwon, K.B.8
Park, B.H.9
-
233
-
-
36448981390
-
Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology
-
Schreibelt G, van Horssen J, van Rossum S, Dijkstra CD, Drukarch B, de Vries HE. Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology. Brain Res Rev 2007;56:322-330.
-
(2007)
Brain Res Rev
, vol.56
, pp. 322-330
-
-
Schreibelt, G.1
Van Horssen, J.2
Van Rossum, S.3
Dijkstra, C.D.4
Drukarch, B.5
De Vries, H.E.6
-
234
-
-
3042716482
-
Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
-
Lee JM, Chan K, Kan YW, Johnson JA. Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia. Proc Natl Acad Sci USA 2004;101:9751-9756.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9751-9756
-
-
Lee, J.M.1
Chan, K.2
Kan, Y.W.3
Johnson, J.A.4
-
235
-
-
77951710223
-
Nuclear factor (Erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells
-
Hong YB, Kang HJ, Kwon SY, Kim HJ, Kwon KY, Cho CH, Lee JM, Kallakury BV, Bae I. Nuclear factor (Erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells. Pancreas 2010;39:463-472.
-
(2010)
Pancreas
, vol.39
, pp. 463-472
-
-
Hong, Y.B.1
Kang, H.J.2
Kwon, S.Y.3
Kim, H.J.4
Kwon, K.Y.5
Cho, C.H.6
Lee, J.M.7
Kallakury, B.V.8
Bae, I.9
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