High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

Toxicological Sciences

Volumn 59, Issue 1, 2001, Pages 169-177

  Enomoto, Akiko ^a   Itoh, Ken ^b   Nagayoshi, Eiko ^a   Haruta, Junko ^a   Kimura, Toyoe ^a   O'Connor, Tania ^b   Harada, Takanori ^a   Yamamoto, Masayuki ^b  

^a INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

glutamylcysteine synthetase; Acetaminophen; ARE; Eletrophile; Glutathione; Hepatotoxicity; Knockout mice; Nrf2; Oxidative stress; UDP Glucuronosyltransferase

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; BETA GLOBIN; BUTYLATED HYDROXYANISOLE; CATALASE; COMPLEMENTARY DNA; DNA; DRUG METABOLIZING ENZYME; DRUG VEHICLE; GLUCURONOSYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE; LEUCINE ZIPPER PROTEIN; MESSENGER RNA; NUCLEAR FACTOR; OXIDOREDUCTASE; PARACETAMOL GLUCURONIDE; PEROXIREDOXIN; PROPYLENE GLYCOL; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF E2; UNINDEXED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG EXPOSURE; DRUG SENSITIVITY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; IMMUNOREACTIVITY; KNOCKOUT MOUSE; LIVER NECROSIS; LIVER TOXICITY; MALE; MORTALITY; MOUSE; NONHUMAN; PHARMACOGENETICS; PROTEIN EXPRESSION; SURVIVAL;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEPATITIS, TOXIC; HETEROZYGOTE; HOMOZYGOTE; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MICROSOMES, LIVER; NF-E2-RELATED FACTOR 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0035153227     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/59.1.169     Document Type: Article

References (40)

1. The Kelch repeat superfamily of proteins: Propellers of cell function
2. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
3. Immunohistochemical localization of acetaminophen-bound liver proteins
4. Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers
5. Effect of piperonyl butoxide post-treatment on acetaminophen hepatotoxicity
6. Induction of Phase I and Phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz
7. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
8. Nrf2 is essential for protection against acute pulmonary injury in mice
9. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
10. Acetaminophen-induced hepatotoxicity
11. Protection against acetaminophen-induced hepatotoxicity by prior treatment with fenitrothion
12. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
13. The characterization of antioxidants
14. Free radicals and antioxidants in food and in vivo: What they do and how they work
15. Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo
16. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
17. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
18. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
19. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
20. Acetaminophen does not decrease hepatic 3′-phosphoadenosine 5′-phosphosulfate in mice
21. Oxidative stress in nongenotoxic carcinogenesis
22. Molecular cloning and functional characterization of a new Cap'n'Collar family transcription factor Nrf3
23. Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption
24. Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity
25. Protein measurement with the Folin phenol reagent
26. Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts
27. Genetic analysis of ageing: Role of oxidative damage and environmental stresses
28. Acetaminophen-induced hepatic necrosis: I. Role of drug metabolism
29. Isolation of NF-E2-related factor 2 (Nrf2), an NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region
30. Up-regulation of the human γ-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element
31. The carbon monoxide-binding pigment of liver microsomes: I. Evidence for its hemoprotein nature
32. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens
33. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream anti-oxidant-responsive elements (ARE)
34. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry
35. Antioxidants and carcinogenesis
36. Oxygen toxicity and antioxidants: State of the art
37. Inhibition of the induction of cancer by antioxidants
38. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
39. 1 gene
40. Kelch encodes a component of intracellular bridges in Drosophila egg chambers