Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 10, 2004, Pages 3381-3386

  Suh, Jung H ^a   Shenvi, Swapna V ^a   Dixon, Brian M ^a   Liu, Honglei ^b   Jaiswal, Anil K ^c   Liu, Rui Ming ^b   Hagen, Tory M ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA GLUTAMYLCYSTEINE; GAMMA GLUTAMYLCYSTEINE LIGASE; GLUTATHIONE; LIGASE; NUCLEAR FACTOR ERYTHROID2 RELATED FACTOR 2; NUCLEAR PROTEIN; PROTECTIVE AGENT; THIOCTIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADOLESCENT; AGED; AGING; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL NUCLEUS; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME SUBUNIT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GLUTATHIONE METABOLISM; INTRACELLULAR TRANSPORT; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DNA BINDING; PROTEIN TRANSPORT; RAT; SUPERSHIFT ASSAY;

AGING; ANIMALS; ANTIOXIDANTS; DNA-BINDING PROTEINS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; LIVER; MALE; NF-E2-RELATED FACTOR 2; PROTEIN SUBUNITS; RATS; RATS, INBRED F344; RNA, MESSENGER; THIOCTIC ACID; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 1542723493     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400282101     Document Type: Article

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