Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways

Free Radical Biology and Medicine

Volumn 21, Issue 3, 1996, Pages 323-333

  Monteiro, Hugo P ^a   Stern, Arnold ^b  

^a FUNDAÇÃO PRÓ SANGUE HEMOCENTRO DE SÃO PAULO   (Brazil)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Epidermal growth factor; Free radicals; Nitric oxide; Protein tyrosine kinases; Protein tyrosine phosphatases; Reactive oxygen species; Signal transduction; Sulfhydryls

Indexed keywords

EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; HYDROGEN PEROXIDE; INSULIN RECEPTOR; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE;

CELL ADHESION; CELL DIFFERENTIATION; HUMAN; MITOGENESIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029758783     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(96)00051-2     Document Type: Review

References (107)

1. 1. Ullrich, A.; Schlessinger, J. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212; 1990.
2. 2. Cadena, D. L.; Gill, G. N. Receptor tyrosine kinases. FASEB J. 6:2332-2337; 1992.
3. 3. Kazlauskas, A. Receptor tyrosine kinases and their targets. Curr. Opin. Gen. Dev. 4:5-14; 1994.
4. 4. McConkey, D. J.; Orrenius, S. Signal transduction pathways to apoptosis. Trends Cell. Biol. 4:370-375; 1994.
5. 5. Fischer, E. H.; Charbonneau, H.; Tonks, N. K. Protein tyrosine phosphatases: A diverse family of intracellular and transmembrane enzymes. Science 253:401-406; 1991.
6. 6. Stone, R.; Dixon, J. E. Protein tyrosine phosphatases. J. Biol. Chem. 269:31323-31326; 1994.
7. 7. Clark, E. A.; Brugge, J. S. Integrins and signal transduction pathways: The road taken. Science 268:233-239; 1995.
8. 8. Ziegler, D. M. Role of reversible oxidation-reduction of enzymes thiols-disulfides in metabolic regulation. Annu. Rev. Biochem. 54:305-329; 1985.
9. 9. Rahman, S. M. J.; Pu, M.; Hamaguchi, M.; Iwamoto, T.; Isobe, K.; Nakashima, I. Redox-linked ligand-independent cell surface triggering for extensive protein tyrosine phosphorylation. FEBS Lett. 317:35-38; 1993.
10. 10. Swarup, G.; Cohen, S.; Garbers, D. L. Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun. 107:1104-1109; 1982.
11. 11. Chan, T. M.; Chen, E.; Tatoyan, A.; Shargill, N. S.; Pleta, M.; Hochstein, P. Stimulation of tyrosine specific protein phosphorylation in the rat liver plasma membrane by oxygen radicals. Biochem. Biophys. Res. Commun. 139:439-445; 1986.
12. 12. Bauskin, A. R.; Alkalay, I.; Ben-Neriah, Y. Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum. Cell 66:685-696; 1991.
13. 13. Monteiro, H. P.; Ivaschenko, Y.; Fischer, R.; Stern, A. Inhibition of protein tyrosine phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts. FEBS Lett. 295:146-148; 1991.
14. 14. Lander, H. M.; Sehajpal, P.; Levine, D. M.; Novogrodsky, A. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J. Immunol. 150:1509-1516; 1993.
15. 15. Stern, A. Oxidative stress and growth factor-mediated signal transduction. In: Pasquier. C.; Olivier, R. Y.; Auclair, C.; Packer, L. eds. Oxidative stress, cell activation and viral infection. Basel: Birkhauser Verlag; 1994; 1994:35-42.
16. 16. Peranovich, T. M. S.; da Silva, A. M.; Fries, D. M.; Stern, A.; Monteiro, H. P. Nitric oxide stimulates tyrosine phosphorylation in murine fibroblasts in the absence and presence of epidermal growth factor. Biochem. J. 305:613-619; 1995.
17. 17. Erpel, T.; Courtneidge, S. A. Src family protein tyrosine kinases and cellular signal transduction pathways. Curr. Opin. Cell. Biol. 7:176-182; 1995.
18. 18. Kypta, R. M.; Goldberg, Y.; Ulug, E. T.; Courtneidge, S. A. Association between the PDGF receptor and members of the Src family of tyrosine kinases. Cell 62:481-492; 1990.
19. 19. Oude Weernink, P. A.; Ottenhoff-Kalff, A. E.; Vendrig, M. P.; Van Beurden, E. A. C. M.; Staal, G. E. J.; Rijksen, G. Functional interaction between the epidermal growth factor receptor and c-Src kinase activity. FEBS Lett. 352:296-300; 1994.
20. FAK. Mol. Cell. Biol. 14:147-155; 1994.
21. 21. Taniguchi, T. Cytokine signaling through nonreceptor tyrosine kinases. Science 268:251-255; 1995.
22. 22. Golden, A.; Brugge, J. S. Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc. Natl. Acad. Sci USA. 86:901-905; 1989.
23. 23. Devary, Y.; Gottlieb, R. A.; Smeal, T.; Karin, M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71:1081-1091; 1992.
24. 24a.Brown-Shimer, S.; Johnson, K. A.; Hill, D. E.; Bruskin, A. M. Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene. Cancer Res. 52:478-482: 1992.
25. 24b.Akiyama, T.; Matsuda, S.; Namba, Y.; Saito, T.; Toyoshima, K.; Yamamoto, T. The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxy terminal domain. Mol. Cell. Biol. 11:833-842; 1991.
26. 25. Rodrigues, G. A.; Park, M. Oncogenic activation of tyrosine kinases. Curr. Opin. Gen. Dev. 4:15-24; 1994.
27. 26. Trowbridge, I.S.; Ostergaard, H. L.; Johnson, P. CD45: A leukocyte-specific member of the protein tyrosine phosphatase family. Biochim. Biophys. Acta. 1095:46-56; 1991.
28. 27. Sun, H.; Tonks, N. K. The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. Trends. Biochem. Sci. 19:480-485; 1994.
29. 28. Tonks, N. K.; Diltz, C. D.; Fischer, E. H. Purification of the major protein tyrosine phosphatases of human placenta. J. Biol. Chem. 263:6722-6730; 1988.
30. 29. Flint, A. J.; Gebink, M. F. G. B.; Franza, B. R.; Hill, D. E.; Tonks, N. K. Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identificaion of cell cycle regulated and phorbol ester stimulated sites of phosphorylation. EMBO J. 12:1937-1946; 1993.
31. 30. Guan, K.; Broyles, S. S.; Dixon, J. E. A tyr/ser protein phosphatase encoded by vaccinia virus. Nature 350:359-362; 1991.
32. gag-fps. Mol. Cell. Biol. 6:4396-4408; 1986.
33. 32. Cicchetti, P.; Mayer, B. J.; Theil, G.; Baltimore, D. Identification of a protein that binds to the SH3 region of Ab1 and is similar to Bcr and GAP-Rho. Science 257:803-806; 1992.
34. 33. Schlessinger, J. SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev. 4:25-30; 1994.
35. 34. Johnson, G. L.; Vaillancourt, R. R. Sequential protein kinase reactions controlling cell growth and differentiation. Curr. Opin. Cell. Biol. 6:230-238: 1994.
36. 35. Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature 361:315-325; 1993.
37. 36. Nishizuka, Y. Intracellular signaling by hydrolyis of phospholipids and activation of protein kinase C. Science 258:607-614; 1992.
38. 37. Kolch, W.; Heidecker, G.; Kochs, G.; Hummel, R.; Vahidi, H.; Mischak, H.; Finkenzeller, G.; Marmé, D.; Rapp, U. R. Protein kinase C activates RAF-1 by direct phosphorylation. Nature 364:249-252; 1993.
39. 38. Avruch, J.; Zhang, X-F.; Kyriakis, J. M. Raf meets Ras: Completing the framework of a signal transduction pathway. Trends. Biochem. Sci. 19:279-283; 1994.
40. 39. McCormick, F. How receptors turn Ras on. Nature 363:15-16; 1993.
41. 40. Li, N.; Batzer, A.; Daly, R.; Yajnik, V.; Skolnik, E.; Chardin, P.; Bar-Sagi, D.; Margolis, B.; Schlessinger. J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363:85-88; 1993.
42. 41. Egan, S. E.; Giddings, B. W.; Brooks, M. W.; Buday, L.; Sizeland, A. M.; Weinberg, R. A. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45-51; 1993.
43. 42. Rodrigues-Viciana, P.; Warne, P. H.; Dhand. R.; Vanhaesebroeck, B.; Gout, I.; Fry, M. J.; Waterfield, M. D.; Downward, J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532; 1994.
44. 43. Dent, P.; Harer, W.; Haystead, T. A. J.; Vincent, L. A.; Roberts, T. M.; Sturgill, T. W. Activation of mitogen-activated protein kinase-kinase by v-Raf in NIH3T3 cells and in vitro. Science 257:1404-1406; 1992.
45. 44. Marshall, C. J. MAP kinase kinase kinase. MAP kinase kinase and MAP kinase. Curr. Opin. Gen. Dev. 4:82-89; 1994.
46. 45. Ettehadieh, E.; Sanghera, J. S.; Pelech, S. L.; Hess-Bienz, D.; Watts, J.; Shastri, N.; Aebersold, R. Tyrosyl phosphorylation and activation of MAP kinases by p561ck. Science 255:853-855; 1992.
47. 46. Gille, H.; Sharrocks, A. D.; Shaw, P. E. Phosphorylation of transcription factor p62 TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414-417; 1992.
48. 47. Davis, R. J. The Mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:14553-14556; 1993.
49. 48. Schaller, M. D.; Hildebrand, J. D.; Shannon, J. D.; Fox, J. W.; Vines, R. R.; Parsons, J. T. Autophosphorylaiton of the focal adhesion kinase pp125FAK, directs SH2-dependent binding of pp60Src. Mol. Cell Biol. 14:1680-1688; 1994.
50. 49. Zhang, J.; King, W. G.; Dillon, S.; Hall, A.; Feig, L.; Rittenhouse, S. E. Activation of platelet phosphatidylinositide-3-kinase requires the small GTP-binding protein Rho. J. Biol. Chem. 268:2251-2254; 1993.
51. 50. Feng, G-S; Pawson, T. Phosphotyrosine phosphatases with SH2 domains: Regulators of signal transduction. Trends Genet. 10:54-58; 1994.
52. 51. Meister, A.; Anderson, M. E. Glutathione. Annu. Rev. Biochem. 52:711-760; 1983.
53. 52. Burdon, R. H.; Rice-Evans, C. Free radicals and the regulation of mammalian cell proliferation. Free Radic. Res. Commun. 6:345-358; 1989.
54. 53. Shibanuma, M.; Kuroki, T.; Nose, M. Induction of DNA replication and expression of protooncogenes c-myc and c-fos in quiescent Balb/3T3 cells by xanthine-xanthine oxidase. Oncogene 3:17-21; 1988.
55. 54. Gallagher, K. E.; Betteridge, L. J.; Patel, M. K.; Schacter, M. Effects of oxidants on vascular smooth muscle proliferation. Biochem. Soc. Trans. 21:98S; 1993.
56. 2+-dependent thiol activation of fat cell glucose utilization. J. Biol. Chem. 249:1001-1006; 1974.
57. 56. May, J. M.; de Haen, C. The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes. J. Biol. Chem. 254:9017-9021; 1979.
58. 57. Koshio, O.; Akanuma, Y.; Kasuga, M. Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells. Biochem. J. 250:95-101; 1988.
59. 2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J. Biol. Chem. 265:2896-2902; 1990.
60. 2 potentiates phosphorylation of novel putative substrates for the insulin receptor kinase in intact Fao cells. J. Biol. Chem. 264:10126-10132; 1989.
61. 2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase. J. Clin. Invest. 89:1006-1013; 1992.
62. 2 for platelet derived growth factor signal transduction. Science 270:296-299; 1995.
63. lck in T cells. Oncogene 8:3133-3139; 1993.
64. 2 and vanadate concomitantly stimulates protein tyrosine phosphorylation and polyphosphoinositide breakdown in different cell lines. Biochemistry 29:10240-10245; 1990.
65. 64. Weber, J. R.; Bell, G. M.; Han, M. Y.; Pawson, T.; Imboden, J. B. Association of the tyrosine kinase Lck with phospholipase C γ 1 after stimulation of the T cell antigen receptor. J. Exp. Med. 176:373-379; 1992.
66. 65. Larsson, R.; Cerutti, P. Oxidants induce phosphorylation of ribosomal protein S6. J. Biol. Chem. 263:17452-17458; 1988.
67. 2 stimulate Mitogen-activated protein kinase activity in N1H-3T3 cells through formation of reactive oxygen intermediates. Cancer Res. 54:12-15; 1994.
68. 67. Rao, G. N.; Lassègue, B.; Griendling, K. K.; Alexander, R. W. Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid. Oncogene 8:2759-2764; 1993.
69. 68. Rao, G. N.; Runge, M. S.; Alexander, R. W. Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells. Biochim. Biophys. Acta 1265:67-72; 1995.
70. 69. Nolan, G. P.; Baltimore, D. The inhibitory ankyrin and activator Rel proteins. Curr. Opin. Genet. Dev. 2:211-220; 1992.
71. 70. Bauerle, P. The inducible transcription activator NF-κB: Regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63-80; 1991.
72. 71. Anderson, M. T.; Staal, F. J. T.; Gitler, C.; Herzenberg, L. A.; Herzenberger, L. A. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway. Proc. Natl. Acad. Sci. USA 91:11527-11531; 1994.
73. 2. Arch. Biochem. Biophys 287:8-17; 1991.
74. 73. Shi, X.; Sun, X.; Dalal, N. S. Reaction of vanadium (V) with thiols generates vanadium (IV) and thiyl radicals. FEBS Lett. 271:185-188; 1990.
75. 2. J. Biol. Chem. 262:8252-8256; 1987.
76. 75. Teshima, R.; Ikebuchi, H.; Nakanishi, M.; Sawada, J. Stimulatory effect of pervanadate on calcium signals and histamine secretion in RBL-2H3 cells. Biochem. J. 302:867-874; 1994.
77. 76. Posner, B. I.; Faure, R.; Burgess, J. W.; Bevan, A. P.; Lachance, D.; Zhang-Sun, G.; Fantus, G.; Ng, J. B; Hall, D. A.; Lum, B. S.; Shave, A. Peroxovanadium compounds. J. Biol. Chem. 269:4596-4604; 1994.
78. 77. Bachur, N. R.; Gordon, S. L.; Gee, M. V. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res. 38:1745-1750; 1978.
79. 78. Chen, Y.; Yang, D-C.; Brown, A. B.; Jeng, Y.; Tatoyan, A.; Chan, T. M. Activation of a membrane-associated phosphatidylinositol kinase through tyrosine-protein phosphorylation by naphthoquinones and orthovanadate. Arch. Biochem. Biophys. 283:184-192; 1990.
80. 79. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051-3064; 1992.
81. 80. Knowles, R. G.; Moncada, S. Nitric oxide synthases in mammals. Biochem. J. 298:249-258; 1994.
82. 81. Ignarro, L. J.; Lippton, H.; Edwards, J. C.; Baricos, W. H.; Hyman, A. L.; Kadowitz, P. J.; Gruetter, C. A. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J. Pharmacol. Exp. Ther. 218:739-749; 1981.
83. 82. Garg, U. C.; Hassid, A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest. 83:1774-1777; 1989.
84. 83. Werner-Felmayer, G.; Werner, E. R.; Fuchs, D.; Hausen, A.; Reibnegger, G.; Wachter, H. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J. Exp. Med. 172:1599-1607; 1990.
85. 84. Leibovich, J. S.; Polverini, P. J.; Fong, T. W.; Harlow, L. A.; Koch, A. E. Production of angiogenic activity by human monocytes requires an L-arginine/nitric-oxide-synthase-dependent effector mechanism. Proc. Natl. Acad. Sci. USA 91:4190-4194; 1994.
86. 85. Ziche, M.; Morbidelli, L.; Masini, E.; Amerini, S.; Granger, H. J.; Maggi, C. A.; Geppetti, P.; Ledda, F. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94:2036-2044; 1994.
87. 86. Jenkins, D. C.; Charles, I. G.; Thomsen, L. L.; Moss, D. W.; Holmes, L. S.; Baylis, S. A.; Rhodes, P.; Westmore, K.; Emson, P. C.; Moncada, S. Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci. USA 92:4392-4396; 1995.
88. 87. Stamler, J. S.; Singel, D. J.; Loscalzo, J. Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898-1902; 1992.
89. 88. Stamler, J. S. Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell 78:931-936; 1994.
90. ras. J. Biol. Chem. 270:7017-7020; 1995.
91. 90. Monteiro, H. P.; Peranovich, T. M. S.; Fries, D. M.; Stern, A.; Silva, A. M. Nitric oxide potentiates EGF-stimulated tyrosine kinase activity in 3T3 cells expressing human EGF receptors. In: Asada, K.; Yoshikawa, T., eds. Frontiers of reactive oxygen species in biology and medicine. Amsterdam: Elsevier Science; 1994; 1994:215-218.
92. 91. Clementi, E.; Sciorati, C.; Riccio, M.; Miloso, M.; Meldolesi, J.; Nisticó, G. Nitric oxide action on growth factor-elicited signals. J. Biol. Chem. 270:22277-22282; 1995.
93. 92. Chen, Q.; Kinch, M. S.; Lin, T. H.; Burridge, K.; Juliano, R. L. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269:26602-26605; 1994.
94. 93. Heck, D. E.; Laskin, D. L.; Gardner, C. R.; Laskin, J. D. Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. J. Biol. Chem. 267:21277-21280; 1992.
95. 94. Scott-Burden, T.; Schini, V. B.; Elizondo, E.; Junquero, D. C.; Vanhoutte, P. M. Platelet-derived growth factor supresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation. Circ. Res. 71:1088-1100; 1992.
96. 95. Novogrodsky, A.; Vanichkin, A.; Patya, M.; Gazit, A.; Osherov, N.; Levitzki, A. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264:1319-1322; 1994.
97. 96. Fries, D. M.; Penha, R. G.; DAmico, E. A.; Abdalla, D. S. P.; Monteiro, H. P. Oxidized low density lipoprotein stimulates nitric oxide release by rabbit aortic endothelial cells. Biochem. Biophys. Res. Commun. 207:231-237; 1995.
98. 97. Caselli, A.; Camici, G; Giampaolo, M; Moneti, G; Pazzagli, L; Cappugi, G; Ramponi, G. Nitric oxide causes inactivation of the low molecular weight phosphotyrosine protein phosphatase. J. Biol. Chem. 269:24878-24882; 1994.
99. 98. Ostergaard, H.L.; Trowbridge, I. S. Negative regulation of CD45 tyrosine phosphatase activity by ionomycin in T cells. Science 253:1423-1425; 1991.
100. 2+ ionophore A23187. Eur. J. Pharmacol. 247:73-80; 1993.
101. 100. Kosower, N. S.; Kosower, E. M. Formation of disulphides with diamide. Methods Enzymol. 143:264-270: 1987.
102. 101. Monteiro, H. P.; Ivaschenko, Y; Fischer, R; Stern, A. Ascorbic acid inhibits protein tyrosine phosphatases in NIH 3T3 cells expressing human epidermal growth factor receptors. Int. J. Biochem. 25:1859-1864; 1993.
103. 102. Hernandez-Sotomayor, S. M. T.; Arteaga, C. L.; Soler, C.; Carpenter. G. Epidermal growth factor stimulates substrate-selective protein tyrosine phosphatase activity. Proc. Natl. Acad. Sci. USA 90:7691-7695; 1993.
104. 103. Stanton, R. C.; Seifter, J. L. Epidermal growth factor rapidly activates the hexose monophosphate shunt in kidney cells. Am. J. Physiol. 254:C267-C271; 1988.
105. 2 on protein tyrosine phosphatase activity in HER14 cells. Free Radic. Biol. Med. 16:399-403; 1994.
106. 105. Fialkow, L.; Chan, C. K.; Rotin, D.; Grinstein, S.; Downey, G. P. Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. J. Biol. Chem. 269:31234-31242; 1994.
107. 106. Santini, F.; Beaven, M. A. Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. J. Biol. Chem. 268:22716-22722; 1993.