Simvastatin activates Keap1/Nrf2 signaling in rat liver

Journal of Molecular Medicine

Volumn 86, Issue 11, 2008, Pages 1279-1285

  Habeos, Ioannis G ^a   Ziros, Panos G ^a,b   Chartoumpekis, Dionysios ^a   Psyrogiannis, Agathoklis ^a   Kyriazopoulou, Venetsana ^a   Papavassiliou, Athanasios G ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

GPX2; Hepatocyte; HO 1; Nrf2; Oxidative stress; Simvastatin

Indexed keywords

CHOLESTEROL; GLUTATHIONE PEROXIDASE 2; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; MEVALONIC ACID; SIMVASTATIN; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; LIVER; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; ANTIOXIDANTS; CELL NUCLEUS; CELLS, CULTURED; CHOLESTEROL; DNA; GLUTATHIONE PEROXIDASE; HEME OXYGENASE-1; HEPATOCYTES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MEVALONIC ACID; NF-E2-RELATED FACTOR 2; PROTEIN TRANSPORT; PROTEINS; RATS; RATS, WISTAR; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 54249119465     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0393-4     Document Type: Article

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