Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Molecular Cell

Volumn 21, Issue 5, 2006, Pages 689-700

  Padmanabhan, Balasundaram ^a   Tong, Kit I ^b   Ohta, Tsutomu ^c   Nakamura, Yoshihiro ^a   Scharlock, Maria ^a   Ohtsuji, Makiko ^b   Kang, Moon Il ^b   Kobayashi, Akira ^b   Yokoyama, Shigeyuki ^a,d,e   Yamamoto, Masayuki ^b  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d RIKEN HARIMA INSTITUTE   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYSTEINE; GLYCINE; KELCH LIKE ECH ASSOCIATING PROTEIN 1; PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYDROGEN BOND; LUNG CANCER; MOUSE; NONHUMAN; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEFECT; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SOMATIC MUTATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOSKELETAL PROTEINS; DNA GLYCOSYLASES; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 2; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33344456501     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.01.013     Document Type: Article

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