Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages

Carcinogenesis

Volumn 23, Issue 6, 2002, Pages 983-991

  Lo, Ai Hsiang ^a   Liang, Yu Chih ^a   Lin Shiau, Shoei Yn ^a   Ho, Chi Tang ^b   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARNOSIC ACID; CARNOSOL; DNA; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN P42; PROTEIN P44; ROSMARINIC ACID; ROSMARINUS OFFICINALIS EXTRACT; SCAVENGER; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; URSOLIC ACID;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG STRUCTURE; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETIC TRANSFECTION; IC 50; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0036316905     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.6.983     Document Type: Article

References (63)

1. Phytochemicals in teas and rosemary and their cancer preventive properties
2. Herbal Medicines-A Guide For Health Care Professionals
3. Antimicrobial activity of carnosol and ursolic acid: Two anti-oxidant constituents of Rosmarinus officinalis L
4. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid
5. Carcinogenicity of butylated hydroxyanisole in F344 rats
6. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and of in vivo formation of mammary DMBA-DNA adducts by rosemary extract
7. Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production
8. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid
9. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid
10. Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention
11. Nitric oxide as a secretory product of mammalian cells
12. Nitric oxide: Physiology, pathophysiology, and pharmacology
13. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
14. Nitric oxide, a novel biologic messenger
15. Therapy of cancer metastasis by activation of the inducible nitric oxide synthase
16. Nitric oxide synthases: Roles, tolls, and controls
17. Regulation of biosynthesis of nitric oxide
18. Role of nitric oxide in immune-mediated diseases
19. Macrophage cytotoxicity: Role for L-arginine deiminase and imino nitrogen oxidation to nitrite
20. Potential genotoxicity of chronically elevated nitric oxide: A review
21. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors
22. DNA damage and mutation in human cells exposed to nitric oxide in vitro
23. NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide
24. Amelioration of chronic ileitis by nitric oxide synthase inhibition
25. Free radicals, antioxidants and human disease: Curiosity, cause, or consequence?
26. Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
27. Free radicals as mediators of tissue injury and disease
28. Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention
29. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
30. I kappa B: A specific inhibitor of the NF-kappa B transcription factor
31. NF-kappa B: Ten years after
32. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
33. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes
34. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
35. Inhibition of extracellular signal-regulated kinase suppresses endotoxin-induced nitric oxide synthesis in mouse macrophages and in human colon epithelial cells
36. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB
37. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol
38. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
39. Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1
40. Antioxidant properties of aspirin: Characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-kappaB activation, and TNF-alpha production
41. Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B
42. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
43. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
44. Chemistry of iron and copper in radical reactions
45. Antioxidant properties of plant flavonoids
46. Chemistry and antioxidative factors in rosemary and sage
47. Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages
48. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide
49. In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB
50. Regulation of NF-kappa B activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester
51. NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C and Ca(2+)-regulated kinases
52. Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line, J774
53. Silica-induced nuclear factor-kappaB activation: Involvement of reactive oxygen species and protein tyrosine kinase activation
54. Enhancement of nuclear factor-kappaB activation and protein tyrosine phosphorylation by a tyrosine phosphatase inhibitor, pervanadate, involves reactive oxygen species in silica-stimulated macrophages
55. Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I kappa B-alpha in RAW264.7 macrophages
56. Diethyldithiocarbamate inhibits induction of macrophage NO synthase
57. Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta
58. N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes
59. Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acid
60. Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms
61. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
62. Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages
63. Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages