Superoxide dismutase as a target for the selective killing of cancer cells

Nature

Volumn 407, Issue 6802, 2000, Pages 390-395

  Huang, Peng ^a   Feng, Li ^a   Oldham, Elizabeth A ^a   Keating, Michael J ^a   Plunkett, William ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DAMAGE; CELL KILLING; CELL PROTECTION; CELL SURVIVAL; ENZYME ACTIVITY; LEUKEMIA CELL; LYMPHOCYTE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; TARGET CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ESTRADIOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HL-60 CELLS; HUMAN; LEUKEMIA; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTES; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDE DISMUTASE; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0034699513     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35030140     Document Type: Article

References (27)

1. Halliwell, B. & Gutterridge, J. M. C. Free Radicals in Biology and Medicine (Oxford Univ. Press, New York, 1985).
2. Fridovich, I. Superoxide radical and superoxide dismutase. Annu. Rev. Biochem. 64, 97-112 (1995).
3. Oberley, L. W. & Buettner, G. R. Role of superoxide dismutase in cancer: a review. Cancer Res 39, 1141-1149 (1979).
4. Dionisi, O., Galeotti, T., Terranova, T. & Azzi, A. Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues. Biochim. Biophys. Acta 403, 292-300 (1975).
5. Marklund, S. L., Westman, N. G., Lundgren, E. & Roos, G. Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res. 42, 1955-1961 (1982).
6. Van Driel, B. E. & Van Noorden, C. J. Oxygen insensitivity of the histochemical assay of glucose-6-phosphate dehydrogenase activity for the discrimination between nonmalignant and malignant cells. J. Histochem. Cytochem. 47, 575-582 (1999).
7. Shulyakovskaya, T., Sumegi, L. & Gal, D. In vivo experimental studies on the role of free radicals in photodynamic therapy. I. Measurement of the steady state concentration of free radicals in tumor tissues of mice. Biochem. Biophys. Res. Commun. 95, 581-587 (1993).
8. Cushman, M., He, H. -M., Katzenellenbogen, J. A., Lin, C. M. & Hamel, E. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. J. Med. Chem. 38, 2041-2049 (1995).
9. Mukhopadhyay, T. & Roth, J. A. Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis. Oncogene 17, 241-246 (1998).
10. Fujimura, M. et al. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19, 3414-3422 (1999).
11. Bindokas, V. J., Jordan, J., Lee, C. C. & Miller, R. J. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J. Neurosci. 16, 1324-1336 (1996).
12. Ukeda, H., Maeda, S., Ishii, T. & Sawamura, M. Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 3′-1-[(phenylaminol)-carbonyl]-3,4-tetrazolium-bis(4-methoxy-6-nitro) benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase. Anal. Biochem. 251, 206-209 (1997).
13. Zwacka, R. M., Dudus, L., Epperly, M. W., Greenberger, J. S. & Engelhardt, J. F. Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis. Hum. Gene Ther. 9, 1381-1386 (1998).
14. L regulates the membrane potential and volume homeostasis of mitochondria. Cell 91, 627-637 (1997).
15. Marzo, I. et al. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281, 2027-2031 (1998).
16. Li, P. et al. Cytochrome c and ATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997).
17. 2 . Biochem. Biophys. Res. Commun. 63, 1013-1018 (1975).
18. D'Amato, R. J., Lin, C. M., Flynn, E., Folkman, J. & Hamel, E. 2-methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc. Natl Acad. Sci. USA 91, 3964-3968 (1994).
19. Fotsis, T. et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and supresses tumor growth. Nature 368, 237-239 (1994).
20. Gutteridge, J. M., Rowley, D. A. & Halliwell, B. Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of 'catalytic' iron and anti-oxidant activity in extracellular fluids. Biochem. J. 206, 605-609 (1982).
21. Hamana, K. et al. DNA strand scission by enzymatically reduced mitomycin C: evidence for participation of the hydroxyl radical in the DNA damage. Biochem. Int. 10, 301-309 (1985).
22. Pervaiz, S., Ramalingam, J. K., Hirpara, J. L. & Clement, M. Superoxide anion inhibits drug-induced tumor cell death. FEBS Lett. 459, 343-348 (1999).
23. Casppary, W. J. Niziak, C., Lanzo, D. A., Friedman, R. & Bachur, N. R. Bleomycin A2: a ferrous oxidase. Mol. Pharmacol. 16, 256-260 (1979).
24. Young, R. C., Ozols, R. F. & Myers, C. E. The anthracycline antineoplastic drugs. N. Engl. J. Med. 305, 139-153 (1981).
25. Gajewski, E., Rao, G., Nackerdien, Z. & Dizdaroglu, M. Modification of DNA bases in mammalian chromatin by radiation-generated free radicals. Biochemistry 29, 7876-7882 (1990).
26. 2 release from activated human leukocytes using a dihydroxyphenoxazine derivative. J. Immunol. Methods 202, 133-141 (1997).
27. Huang, P., Chubb, S. & Plunkett, W. Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine: a mechanism for cytotoxicity. J. Biol. Chem. 265, 16617-16625 (1990).