-
1
-
-
47749126515
-
Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
-
This article reviews current knowledge on how beneficial inflammation subverts into chronic pathological inflammation through a vicious cycle of interaction between active microglia and damaged neurons
-
Gao HM, Hong JS. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 2008; 29:357-365. This article reviews current knowledge on how beneficial inflammation subverts into chronic pathological inflammation through a vicious cycle of interaction between active microglia and damaged neurons.
-
(2008)
Trends Immunol
, vol.29
, pp. 357-365
-
-
Gao, H.M.1
Hong, J.S.2
-
2
-
-
33845768784
-
Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
-
Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007; 8:57-69.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 57-69
-
-
Block, M.L.1
Zecca, L.2
Hong, J.S.3
-
3
-
-
51649126499
-
Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
-
Hayashi Y, Yoshida M, Yamato M, et al. Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci 2008; 28:8624-8634.
-
(2008)
J Neurosci
, vol.28
, pp. 8624-8634
-
-
Hayashi, Y.1
Yoshida, M.2
Yamato, M.3
-
4
-
-
34548121631
-
The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases
-
Sun GY, Horrocks LA, Farooqui AA. The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases. J Neurochem 2007; 103:1-16.
-
(2007)
J Neurochem
, vol.103
, pp. 1-16
-
-
Sun, G.Y.1
Horrocks, L.A.2
Farooqui, A.A.3
-
5
-
-
3442888512
-
Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma
-
Pawate S, Shen Q, Fan F, Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res 2004; 77:540-551.
-
(2004)
J Neurosci Res
, vol.77
, pp. 540-551
-
-
Pawate, S.1
Shen, Q.2
Fan, F.3
Bhat, N.R.4
-
6
-
-
27444443028
-
Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
-
Qin L, Li G, Qian X, et al. Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. GLIA 2005; 52:78-84.
-
(2005)
GLIA
, vol.52
, pp. 78-84
-
-
Qin, L.1
Li, G.2
Qian, X.3
-
7
-
-
51449112787
-
-
Sun HN, Kim SU, Lee MS, et al. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of phosphoinositide 3-kinase and p38 mitogen-activated protein kinase signal pathways is required for lipopo-lysaccharide-induced microglial phagocytosis. Biol Pharm Bull 2008; 31:1711-1715. This study reports that Nox-derived ROS functions as an upstream regulator of both PI3-K and p38 MAPK in signalling for microglial phagocytosis.
-
Sun HN, Kim SU, Lee MS, et al. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of phosphoinositide 3-kinase and p38 mitogen-activated protein kinase signal pathways is required for lipopo-lysaccharide-induced microglial phagocytosis. Biol Pharm Bull 2008; 31:1711-1715. This study reports that Nox-derived ROS functions as an upstream regulator of both PI3-K and p38 MAPK in signalling for microglial phagocytosis.
-
-
-
-
8
-
-
42249115877
-
Neuroinflammation mediated by IL-1 beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
-
Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. Neuroinflammation mediated by IL-1 beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation 2008; 5:8.
-
(2008)
J Neuroinflammation
, vol.5
, pp. 8
-
-
Koprich, J.B.1
Reske-Nielsen, C.2
Mithal, P.3
Isacson, O.4
-
9
-
-
46849088998
-
Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease
-
Godoy MC, Tarelli R, Ferrari CC, et al. Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain 2008; 131:1880-1894.
-
(2008)
Brain
, vol.131
, pp. 1880-1894
-
-
Godoy, M.C.1
Tarelli, R.2
Ferrari, C.C.3
-
10
-
-
33645242238
-
Nox2 and Rad regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes
-
Li Q, Harraz MM, Zhou W, et al. Nox2 and Rad regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol 2006; 26:140-154.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 140-154
-
-
Li, Q.1
Harraz, M.M.2
Zhou, W.3
-
11
-
-
58149239663
-
CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia
-
This report illustrates a new trend indicating that ion channels such as CLIC1 are activated in response to redox modulation by NADPH oxidase-derived ROS, and provide a feed-forward mechanism that facilitates sustained microglial ROS generation
-
Milton RH, Abeti R, Averaimo S, et al. CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia. J Neurosci 2008; 28:11488-11499. This report illustrates a new trend indicating that ion channels such as CLIC1 are activated in response to redox modulation by NADPH oxidase-derived ROS, and provide a feed-forward mechanism that facilitates sustained microglial ROS generation.
-
(2008)
J Neurosci
, vol.28
, pp. 11488-11499
-
-
Milton, R.H.1
Abeti, R.2
Averaimo, S.3
-
12
-
-
34948869744
-
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
-
Anantharam V, Kaul S, Song C, et al. Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology 2007; 28:988-997.
-
(2007)
Neurotoxicology
, vol.28
, pp. 988-997
-
-
Anantharam, V.1
Kaul, S.2
Song, C.3
-
13
-
-
39049134842
-
Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia
-
Yang CS, Lee HM, Lee JY, et al. Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia. J Neuroinflammation 2007; 4:27.
-
(2007)
J Neuroinflammation
, vol.4
, pp. 27
-
-
Yang, C.S.1
Lee, H.M.2
Lee, J.Y.3
-
14
-
-
20144389524
-
Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson's disease
-
Zhang W, Wang T, Pei Z, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005; 19:533-542.
-
(2005)
FASEB J
, vol.19
, pp. 533-542
-
-
Zhang, W.1
Wang, T.2
Pei, Z.3
-
15
-
-
20644444103
-
Neutrophil beta2 integrins: Moderators of life or death decisions
-
Mayadas TN, Cullere X. Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol 2005; 26:388-395.
-
(2005)
Trends Immunol
, vol.26
, pp. 388-395
-
-
Mayadas, T.N.1
Cullere, X.2
-
16
-
-
58149181977
-
-
Hu X, Zhang D, Pang H, et al. Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Immunol 2008; 181:7194-7204. This report demonstrates that Mac-1 plays a critical role in MPTP/MPP(+)-induced reactive microgliosis and further supports the hypothesis that reactive microgliosis is an essential step in the self-perpetuating cycle leading to progressive dopaminergic neurodegeneration observed in Parkinson's disease.
-
Hu X, Zhang D, Pang H, et al. Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Immunol 2008; 181:7194-7204. This report demonstrates that Mac-1 plays a critical role in MPTP/MPP(+)-induced reactive microgliosis and further supports the hypothesis that reactive microgliosis is an essential step in the self-perpetuating cycle leading to progressive dopaminergic neurodegeneration observed in Parkinson's disease.
-
-
-
-
17
-
-
34548213150
-
MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity
-
Pei Z, Pang H, Qian L, et al. MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity. GLIA 2007; 55:1362-1373.
-
(2007)
GLIA
, vol.55
, pp. 1362-1373
-
-
Pei, Z.1
Pang, H.2
Qian, L.3
-
18
-
-
0030879929
-
Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide
-
Goodwin JL, Kehrli ME Jr, Uemura E. Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide. Brain Res 1997; 768:279-286.
-
(1997)
Brain Res
, vol.768
, pp. 279-286
-
-
Goodwin, J.L.1
Kehrli Jr, M.E.2
Uemura, E.3
-
19
-
-
34547637625
-
Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
-
Zhang W, Dallas S, Zhang D, et al. Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. GLIA 2007; 55:1178-1188.
-
(2007)
GLIA
, vol.55
, pp. 1178-1188
-
-
Zhang, W.1
Dallas, S.2
Zhang, D.3
-
20
-
-
48549100286
-
Reactive oxygen species up-regulate CD11 b in microglia via nitric oxide: Implications for neurodegenerative diseases
-
This study demonstrates that up-regulation of Mac-1 /CD11 b in microglia is redox sensitive and that ROS up-regulates Mac-1/CD11 b via nitric oxide
-
Roy A, Jana A, Yatish K, et al. Reactive oxygen species up-regulate CD11 b in microglia via nitric oxide: implications for neurodegenerative diseases. Free Radic Biol Med 2008; 45:686-699. This study demonstrates that up-regulation of Mac-1 /CD11 b in microglia is redox sensitive and that ROS up-regulates Mac-1/CD11 b via nitric oxide.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 686-699
-
-
Roy, A.1
Jana, A.2
Yatish, K.3
-
21
-
-
38849182472
-
-
Harraz MM, Marden JJ, Zhou W, et al. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest 2008; 118:659-670. The authors demonstrate that SOD1 is not only a catabolic enzyme, but also can be a regulator of NADPH oxidase that binds and inhibits Rac1 GTPase activity. This study may explain the gain-of-function seen with certain SOD1 mutations associated with ALS.
-
Harraz MM, Marden JJ, Zhou W, et al. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest 2008; 118:659-670. The authors demonstrate that SOD1 is not only a catabolic enzyme, but also can be a regulator of NADPH oxidase that binds and inhibits Rac1 GTPase activity. This study may explain the gain-of-function seen with certain SOD1 mutations associated with ALS.
-
-
-
-
22
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
Yamanaka K, Chun SJ, Boillee S, et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008; 11:251-253.
-
(2008)
Nat Neurosci
, vol.11
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
-
23
-
-
47949105603
-
Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia
-
This report gives a molecular explanation for the anti-inflammatory effect of TGF-p on microglia, based on inhibition of NADPH oxidase by preventing the ERK-dependent phosphorylation of Ser345 on p47phox
-
Qian L, Wei SJ, Zhang D, et al. Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol 2008; 181:660-668. This report gives a molecular explanation for the anti-inflammatory effect of TGF-p on microglia, based on inhibition of NADPH oxidase by preventing the ERK-dependent phosphorylation of Ser345 on p47phox.
-
(2008)
J Immunol
, vol.181
, pp. 660-668
-
-
Qian, L.1
Wei, S.J.2
Zhang, D.3
-
24
-
-
34548806001
-
Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity
-
Qian L, Tan KS, Wei SJ, et al. Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity. J Immunol 2007; 179:1198-1209.
-
(2007)
J Immunol
, vol.179
, pp. 1198-1209
-
-
Qian, L.1
Tan, K.S.2
Wei, S.J.3
-
25
-
-
67049146235
-
Transcribe to survive: Transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease
-
Clark J, Simon DK. Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease. Antioxid Redox Signal 2008.
-
(2008)
Antioxid Redox Signal
-
-
Clark, J.1
Simon, D.K.2
-
26
-
-
47849083585
-
Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
-
Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 2008; 659:31-39.
-
(2008)
Mutat Res
, vol.659
, pp. 31-39
-
-
Osburn, W.O.1
Kensler, T.W.2
-
27
-
-
58149180772
-
The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease
-
Calkins MJ, Johnson DA, Townsend JA, et al. The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 2008.
-
(2008)
Antioxid Redox Signal
-
-
Calkins, M.J.1
Johnson, D.A.2
Townsend, J.A.3
-
28
-
-
49749117926
-
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death
-
Rojo Al, Rada P, Egea J, et al. Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Mol Cell Neurosci 2008; 39:125-132.
-
(2008)
Mol Cell Neurosci
, vol.39
, pp. 125-132
-
-
Rojo, A.1
Rada, P.2
Egea, J.3
-
29
-
-
41149134840
-
GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: Relevance to exposure of neuronal cells to oxidative stress
-
Rojo Al, Sagarra MR, Cuadrado A. GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress. J Neurochem 2008; 105:192-202.
-
(2008)
J Neurochem
, vol.105
, pp. 192-202
-
-
Rojo, A.1
Sagarra, M.R.2
Cuadrado, A.3
-
30
-
-
56249106571
-
Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
-
Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 2008; 74:1526-1539.
-
(2008)
Planta Med
, vol.74
, pp. 1526-1539
-
-
Surh, Y.J.1
Kundu, J.K.2
Na, H.K.3
-
31
-
-
33750613056
-
Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
-
Tong Kl, Kobayashi A, Katsuoka F, Yamamoto M. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol Chem 2006; 387:1311-1320.
-
(2006)
Biol Chem
, vol.387
, pp. 1311-1320
-
-
Tong, K.1
Kobayashi, A.2
Katsuoka, F.3
Yamamoto, M.4
-
32
-
-
58249144848
-
Inflammatory signaling and cellular senescence
-
Ren JL, Pan JS, Lu YP. Inflammatory signaling and cellular senescence. Cell Signal 2008; 21:378-383.
-
(2008)
Cell Signal
, vol.21
, pp. 378-383
-
-
Ren, J.L.1
Pan, J.S.2
Lu, Y.P.3
-
33
-
-
59349100950
-
Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms
-
Teeling JL, Perry VH. Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Neuroscience 2008; 158:1062-1073.
-
(2008)
Neuroscience
, vol.158
, pp. 1062-1073
-
-
Teeling, J.L.1
Perry, V.H.2
-
34
-
-
38449095421
-
Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation
-
Wang MJ, Lin SZ, Kuo JS, et al. Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation. J Immunol 2007; 179:6204-6214.
-
(2007)
J Immunol
, vol.179
, pp. 6204-6214
-
-
Wang, M.J.1
Lin, S.Z.2
Kuo, J.S.3
-
35
-
-
51349096586
-
-
Kanaan NM, Kordower JH, Collier TJ. Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. GLIA 2008; 56:1199-1214.
-
Kanaan NM, Kordower JH, Collier TJ. Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. GLIA 2008; 56:1199-1214.
-
-
-
-
36
-
-
63349101116
-
Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys
-
Kanaan NM, Kordower JH, Collier TJ. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiol Aging 2008.
-
(2008)
Neurobiol Aging
-
-
Kanaan, N.M.1
Kordower, J.H.2
Collier, T.J.3
-
37
-
-
10744230015
-
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)- prostaglandin j(2)
-
Itoh K, Mochizuki M, Ishii Y, et al. Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)- prostaglandin j(2). Mol Cell Biol 2004; 24:36-45.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 36-45
-
-
Itoh, K.1
Mochizuki, M.2
Ishii, Y.3
-
38
-
-
33750532308
-
Regulation of inflammation and redox signaling by dietary polyphenols
-
Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006; 72:1439-1452.
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1439-1452
-
-
Rahman, I.1
Biswas, S.K.2
Kirkham, P.A.3
-
39
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
Rangasamy T, Cho CY, Thimmulappa RK, et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004; 114:1248-1259.
-
(2004)
J Clin Invest
, vol.114
, pp. 1248-1259
-
-
Rangasamy, T.1
Cho, C.Y.2
Thimmulappa, R.K.3
-
40
-
-
9444249870
-
The transcription factor NRF2 protects against pulmonary fibrosis
-
Cho HY, Reddy SP, Yamamoto M, Kleeberger SR. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004; 18:1258-1260.
-
(2004)
FASEB J
, vol.18
, pp. 1258-1260
-
-
Cho, H.Y.1
Reddy, S.P.2
Yamamoto, M.3
Kleeberger, S.R.4
-
41
-
-
27744450995
-
Transcription factor Nrf 2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema
-
Ishii Y, Itoh K, Morishima Y, et al. Transcription factor Nrf 2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J Immunol 2005; 175:6968-6975.
-
(2005)
J Immunol
, vol.175
, pp. 6968-6975
-
-
Ishii, Y.1
Itoh, K.2
Morishima, Y.3
-
42
-
-
4344688670
-
Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: Protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals
-
Li N, Alam J, Venkatesan Ml, et al. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol 2004; 173:3467-3481.
-
(2004)
J Immunol
, vol.173
, pp. 3467-3481
-
-
Li, N.1
Alam, J.2
Venkatesan, M.3
-
43
-
-
22344438250
-
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
-
Rangasamy T, Guo J, Mitzner WA, et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 2005; 202:47-59.
-
(2005)
J Exp Med
, vol.202
, pp. 47-59
-
-
Rangasamy, T.1
Guo, J.2
Mitzner, W.A.3
-
44
-
-
33645530745
-
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
-
Thimmulappa RK, Lee H, Rangasamy T, et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 2006; 116:984-995.
-
(2006)
J Clin Invest
, vol.116
, pp. 984-995
-
-
Thimmulappa, R.K.1
Lee, H.2
Rangasamy, T.3
-
45
-
-
33750826092
-
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-lmidazolide
-
Thimmulappa RK, Scollick C, Traore K, et al. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-lmidazolide. Biochem Biophys Res Commun 2006; 351:883-889.
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 883-889
-
-
Thimmulappa, R.K.1
Scollick, C.2
Traore, K.3
-
46
-
-
47949083810
-
The transcription factor Nrf2 is a therapeutic target against brain inflammation
-
First demonstration that Nrf2 deficiency sensitizes to LPS-induced neuroinflam-mation and that sulforaphane-mediated activation of Nrf2 results in lower inflammation in hippocampus in response to LPS
-
Innamorato NG, Rojo Al, Garcia-Yague AJ, et al. The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol 2008; 181:680-689. First demonstration that Nrf2 deficiency sensitizes to LPS-induced neuroinflam-mation and that sulforaphane-mediated activation of Nrf2 results in lower inflammation in hippocampus in response to LPS.
-
(2008)
J Immunol
, vol.181
, pp. 680-689
-
-
Innamorato, N.G.1
Rojo, A.2
Garcia-Yague, A.J.3
-
47
-
-
33751503096
-
In vivo modulation of the Parkinsonian phenotype by Nrf2
-
Burton NC, Kensler TW, Guilarte TR. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology 2006; 27:1094-1100.
-
(2006)
Neurotoxicology
, vol.27
, pp. 1094-1100
-
-
Burton, N.C.1
Kensler, T.W.2
Guilarte, T.R.3
-
48
-
-
47349104402
-
Glial reactions in Parkinson's disease
-
McGeer PL, McGeer EG. Glial reactions in Parkinson's disease. Mov Disord 2008; 23:474-483.
-
(2008)
Mov Disord
, vol.23
, pp. 474-483
-
-
McGeer, P.L.1
McGeer, E.G.2
-
49
-
-
51349168245
-
Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro
-
Rohl C, Armbrust E, Kolbe K, et al. Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro. GLIA 2008; 56:1114-1126.
-
(2008)
GLIA
, vol.56
, pp. 1114-1126
-
-
Rohl, C.1
Armbrust, E.2
Kolbe, K.3
-
50
-
-
0038146898
-
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
-
Lee JM, Calkins MJ, Chan K, et al. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 2003; 278:12029-12038.
-
(2003)
J Biol Chem
, vol.278
, pp. 12029-12038
-
-
Lee, J.M.1
Calkins, M.J.2
Chan, K.3
-
51
-
-
0141621061
-
NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
-
Lee JM, Shih AY, Murphy TH, Johnson JA. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem 2003; 278:37948-37956.
-
(2003)
J Biol Chem
, vol.278
, pp. 37948-37956
-
-
Lee, J.M.1
Shih, A.Y.2
Murphy, T.H.3
Johnson, J.A.4
-
52
-
-
0842304134
-
Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
-
Kraft AD, Johnson DA, Johnson JA. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci 2004; 24:1101-1112.
-
(2004)
J Neurosci
, vol.24
, pp. 1101-1112
-
-
Kraft, A.D.1
Johnson, D.A.2
Johnson, J.A.3
-
53
-
-
0037996661
-
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress
-
Shih AY, Johnson DA, Wong G, et al. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci 2003; 23:3394-3406.
-
(2003)
J Neurosci
, vol.23
, pp. 3394-3406
-
-
Shih, A.Y.1
Johnson, D.A.2
Wong, G.3
-
54
-
-
58149379610
-
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
-
This study illustrates the relevance of astroglial Nrf2 in motor neuron protection in a mouse model of ALS with targeted expression of Nrf2 in astrocytes
-
Vargas MR, Johnson DA, Sirkis DW, et al. Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci 2008; 28:13574-13581. This study illustrates the relevance of astroglial Nrf2 in motor neuron protection in a mouse model of ALS with targeted expression of Nrf2 in astrocytes.
-
(2008)
J Neurosci
, vol.28
, pp. 13574-13581
-
-
Vargas, M.R.1
Johnson, D.A.2
Sirkis, D.W.3
-
55
-
-
55949120110
-
Activation of Nrf 2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis
-
This article reviews the available data suggesting that Nrf2 may play an important in role in suppression of NFKB-dependent inflammation
-
Li W, Khor TO, Xu C, et al. Activation of Nrf 2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 2008; 76:1485-1489. This article reviews the available data suggesting that Nrf2 may play an important in role in suppression of NFKB-dependent inflammation.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 1485-1489
-
-
Li, W.1
Khor, T.O.2
Xu, C.3
-
56
-
-
1842555356
-
Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway
-
Jeong WS, Kim IW, Hu R, Kong AN. Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm Res 2004; 21:661-670.
-
(2004)
Pharm Res
, vol.21
, pp. 661-670
-
-
Jeong, W.S.1
Kim, I.W.2
Hu, R.3
Kong, A.N.4
-
57
-
-
22744440329
-
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
-
Xu C, Shen G, Chen C, et al. Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene 2005; 24:4486-4495.
-
(2005)
Oncogene
, vol.24
, pp. 4486-4495
-
-
Xu, C.1
Shen, G.2
Chen, C.3
-
58
-
-
42049090394
-
Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections
-
Cuadrado A, Rojo Al. Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr Pharm Des 2008; 14:429-442.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 429-442
-
-
Cuadrado, A.1
Rojo, A.2
-
59
-
-
0034693445
-
Co-induction of heme oxygenase-1 and peroxiredoxin I in astrocytes and microglia around hemorrhagic region in the rat brain
-
Nakaso K, Kitayama M, Mizuta E, et al. Co-induction of heme oxygenase-1 and peroxiredoxin I in astrocytes and microglia around hemorrhagic region in the rat brain. Neurosci Lett 2000; 293:49-52.
-
(2000)
Neurosci Lett
, vol.293
, pp. 49-52
-
-
Nakaso, K.1
Kitayama, M.2
Mizuta, E.3
-
60
-
-
34548863185
-
Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders
-
Stahnke T, Stadelmann C, Netzler A, et al. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J Mol Neurosci 2007; 32:25-37.
-
(2007)
J Mol Neurosci
, vol.32
, pp. 25-37
-
-
Stahnke, T.1
Stadelmann, C.2
Netzler, A.3
-
61
-
-
0032031011
-
Neural heme oxygenase-1 expression in idiopathic Parkinson's disease
-
Schipper HM, Liberman A, Stopa EG. Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp Neural 1998; 150:60-68.
-
(1998)
Exp Neural
, vol.150
, pp. 60-68
-
-
Schipper, H.M.1
Liberman, A.2
Stopa, E.G.3
-
62
-
-
45549092556
-
Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutro-phil p47phox and p67phox activity and 02-production in a two-hit model of alcohol intoxication and burn injury
-
Li X, Schwacha MG, Chaudry IH, Choudhry MA. Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutro-phil p47phox and p67phox activity and 02-production in a two-hit model of alcohol intoxication and burn injury. J Immunol 2008; 180:6933-6940.
-
(2008)
J Immunol
, vol.180
, pp. 6933-6940
-
-
Li, X.1
Schwacha, M.G.2
Chaudry, I.H.3
Choudhry, M.A.4
-
63
-
-
33749322644
-
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
-
Nakahira K, Kim HP, Geng XH, et al. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med 2006; 203:2377-2389.
-
(2006)
J Exp Med
, vol.203
, pp. 2377-2389
-
-
Nakahira, K.1
Kim, H.P.2
Geng, X.H.3
-
64
-
-
32544455798
-
Astrocytes induce hemeoxygenase-1 expression in microglia: A feasible mechanism for preventing excessive brain inflammation
-
Min KJ, Yang MS, Kim SU, et al. Astrocytes induce hemeoxygenase-1 expression in microglia: a feasible mechanism for preventing excessive brain inflammation. J Neurosci 2006; 26:1880-1887.
-
(2006)
J Neurosci
, vol.26
, pp. 1880-1887
-
-
Min, K.J.1
Yang, M.S.2
Kim, S.U.3
-
65
-
-
38949110010
-
Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
-
Ashino T, Yamanaka R, Yamamoto M, et al. Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. Mol Immunol 2008; 45:2106-2115.
-
(2008)
Mol Immunol
, vol.45
, pp. 2106-2115
-
-
Ashino, T.1
Yamanaka, R.2
Yamamoto, M.3
-
66
-
-
33846819008
-
Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation
-
This study demonstrates a crucial role of HO-1 in inhibition of autoimmune inflammation in experimental autoimmune encephalomyelitis, a model of multiple sclerosis in mice
-
Chora AA, Fontoura P, Cunha A, et al. Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest 2007; 117:438-447. This study demonstrates a crucial role of HO-1 in inhibition of autoimmune inflammation in experimental autoimmune encephalomyelitis, a model of multiple sclerosis in mice.
-
(2007)
J Clin Invest
, vol.117
, pp. 438-447
-
-
Chora, A.A.1
Fontoura, P.2
Cunha, A.3
|