Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity

Biochemical and Biophysical Research Communications

Volumn 339, Issue 1, 2006, Pages 79-88

  Okawa, Hiromi ^a   Motohashi, Hozumi ^a   Kobayashi, Akira ^a   Aburatani, Hiroyuki ^b   Kensler, Thomas W ^c   Yamamoto, Masayuki ^a,d  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Acetaminophen; Alb Cre; ARE; Conditional knockout mice; GST; Hepatotoxicity; Keap1; Nrf2; Phase2 enzymes; UGT

Indexed keywords

PARACETAMOL; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DNA MICROARRAY; GENE; GENE ACTIVATION; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; GERM LINE; HOMOZYGOSITY; KEAP1 GENE; LETHALITY; LIVER CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WEANING;

ACETAMINOPHEN; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANALGESICS; ANIMALS; CYTOSKELETAL PROTEINS; GENE EXPRESSION PROFILING; HEPATITIS, TOXIC; HEPATOCYTES; LIVER; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REGULATORY ELEMENTS, TRANSCRIPTIONAL;

ANIMALIA;

EID: 28144445947     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.10.185     Document Type: Article

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