Reactive oxygen species mediate cellular damage in Alzheimer disease

Journal of Alzheimer's Disease

Volumn 1, Issue 1, 1998, Pages 45-55

  Perry, G ^a   Castellani, R J ^a   Hirai, K ^a   Smith, M A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; PRESENILIN 2; REACTIVE OXYGEN METABOLITE;

AGING; ALZHEIMER DISEASE; APOPTOSIS; CELL DAMAGE; CLINICAL FEATURE; GENETIC ASSOCIATION; GLYCATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0032229327     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-1998-1103     Document Type: Review

References (130)

1. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
2. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
3. Role of oxidative stress in development of complications in diabetes
4. Vitamin E protects nerve cells from amyloid-β protein toxicity
5. Hydrogen peroxide mediates amyloid β protein toxicity
6. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship
7. Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen
8. Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation
9. Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study
10. β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
11. Electrophysiological effects of 25-35 amyloid-β-protein on guinea pig lateral septal neurons
12. Evidence for oxidative stress in Pick disease and corticobasal degeneration
13. Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease
14. Advanced glycation modification of Rosenthal fibers in Alexander disease
15. The role of the Mailard reaction in other pathologies: Alzheimer's disease
16. Production of superoxide anions by a CNS macrophage, the microglia
17. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
18. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains
19. Mechanisms of neuronal death in Alzheimer's disease
20. Neuronal and microglial involvement in β-amyloid protein deposition in Alzheimer's disease
21. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking m Alzheimer disease
22. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
23. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
24. Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease
25. Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles
26. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
27. Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease
28. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study
29. Evidence of neuronal oxidative damage in Alzheimer's disease
30. Nordihydroguaiaretic acid protects hippocampal neurons against amyloid betapeptide toxicity, and attenuates free radical and calcium accumulation
31. Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
32. Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology
33. The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs
34. 2. Role in cell survival following oxidant injury
35. Spin trapping of ibuprofen radicals: Evidence that ibuprofen is a hydroxyl radical scavenger
36. Ageing: A theory based on free radical and radiation chemistry
37. β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: Implications for Alzheimer's disease
38. The epidemiology of estrogen replacement therapy and Alzheimer's disease
39. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
40. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
41. Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease
42. Anti-oxidative therapy with oral dapsone improved HCV antibody positive annular elastolytic giant cell granuloma
43. Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation
44. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1
45. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
46. The toxicity in vitro of β-amyloid protein
47. Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema
48. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
49. Alzheimer's disease
50. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: The Baltimore Longitudinal Study of Aging
51. β-Amyloid protein increases the vulnerability of cultured cortical neuns to excitotoxic damage
52. Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease
53. Analysis of microtubule-associated protein tau glycation in paired helical filaments
54. Inhibitors of free radical formation fail to attenuate direct β-amyloid(25-35) peptide-mediated neurotoxicity in rat hippocampal cultures
55. Selective presence of ubiquitin in intracellular inclusions
56. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
57. A tombstone in Alzheimer's?
58. Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease
59. Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?
60. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
61. Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer disease
62. Apolipoprotein E allelle-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
63. E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures
64. Crosslinking of apolipoprotein E by products of lipid peroxidation
65. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
66. The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation
67. Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide
68. Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids
69. A mechanism for the stimulatory effect of aluminum on iron-induced lipid peroxidation
70. The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: Implications for Alzheimer disease
71. Cytochrome oxidase deficiency in Alzheimer's disease
72. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains
73. Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton
74. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y
75. Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease: An index of oxidative stress
76. Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease
77. Protective effect of transforming growth factor-β 1 on β-amyloid neurotoxicity in rat hippocampal neurons
78. Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease
79. Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells
80. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease
81. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells
82. Clinical trial of indomethacin in Alzheimer's disease
83. Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells
84. On the metabolism of apolipoprotein E and the Alzheimer diseases
85. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
86. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
87. Mechanisms of neurotoxicity associated with amyloid β deposition and the role of free radicals in the pathogenesis of Alzheimer's disease. A critical appraisal
88. Protective action of acetylcarnitine on NADPH-induced lipid peroxidation of cardiac microsomes
89. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
90. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
91. Alzheimer's disease: Insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea
92. Alzheimer's disease: Genotypes, phenotypes, and treatments
93. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
94. An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain
95. Inhibitory effects of tenilsetam on the Maillard reaction
96. Mitochondrial function in brain tissue in primary degenerative dementia
97. Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy
98. Indomethacin and Alzheimer's disease
99. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
100. Alzheimer Disease
101. Alzheimer disease: An imbalance of proteolytic regulation?
102. Advanced Maillard reaction products are associated with Alzheimer disease pathology
103. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
104. Radical AGEing in Alzheimer's disease
105. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease
106. Early AGEing and Alzheimer's
107. Oxidative damage in Alzheimer's
108. Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease
109. Widespread peroxynitrite-mediated damage in Alzheimer's disease
110. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
111. Amyloid-β deposition in Alzheimer transgenic mice initiates oxidative stress
112. Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
113. Aberrant neurofilament phosphorylation in Alzheimer disease
114. Risk of Alzheimer's disease and duration of NSAID use
115. Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse
116. Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
117. Immunohistochemical evidence for apoptosis in Alzheimer's disease
118. A 1-year multicenter placebo-controlled study of acetyl-L-camitine in patients with Alzheimer's disease
119. PHF-τ (A68): From pathological marker to potential mediator of neuronal dysfunction and degeneration in Alzheimer's disease
120. Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites
121. Mechanism of action of aspirin-like drugs
122. Mitotic mechanisms in Alzheimer's disease?
123. Advanced glycation end products contribute to amyloidosis in Alzheimer disease
124. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
125. Suppression of hydroxyl radical formation and protection of nigral neurons by 1-deprenyl (selegiline)
126. Glycated tan protein in Alzheimer disease: A mechanism for induction of oxidant stress
127. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide
128. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
129. Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
130. 2 generation