Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

Journal of Clinical Investigation

Volumn 114, Issue 9, 2004, Pages 1248-1259

  Rangasamy, Tirumalai ^a   Cho, Chung Y ^b   Thimmulappa, Rajesh K ^a   Zhen, Lijie ^b   Srisuma, Sorachai S ^a   Kensler, Thomas W ^a,c   Yamamoto, Masayuki ^d   Petrache, Irina ^b   Tuder, Rubin M ^b   Biswal, Shyam ^a,c  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; CIGARETTE SMOKE; NUCLEAR FACTOR; PROTEINASE; PROTEINASE INHIBITOR; TRANSCRIPTION FACTOR NRF2; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; DNA BINDING PROTEIN; DRUG DERIVATIVE; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DNA MICROARRAY; EMPHYSEMA; ENDOTHELIUM CELL; EPITHELIUM CELL; GENE; GENE CONTROL; GENE DISRUPTION; GENETIC SUSCEPTIBILITY; GENOTYPE; INFLAMMATION; LUNG ALVEOLITIS; LUNG ALVEOLUS CELL; LUNG ALVEOLUS WALL; LUNG BURN; MOUSE; NONHUMAN; NRF2 GENE; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; UNINDEXED SEQUENCE; WILD TYPE; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; LUNG; LUNG ALVEOLUS; LUNG LAVAGE; METABOLISM; NICK END LABELING; OXIDATION REDUCTION REACTION; PATHOLOGY; PHENOTYPE; SMOKING; TIME; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE; DEOXYGUANOSINE; DNA-BINDING PROTEINS; EMPHYSEMA; EPITHELIAL CELLS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; LUNG; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; PHENOTYPE; PULMONARY ALVEOLI; SMOKING; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 15244356847     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200421146     Document Type: Article

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