Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Free Radical Biology and Medicine

Volumn 46, Issue 4, 2009, Pages 443-453

  Harvey, C J ^a   Thimmulappa, R K ^a   Singh, A ^a   Blake, D J ^a   Ling, G ^a   Wakabayashi, N ^a   Fujii, J ^b   Myers, A ^c   Biswal, S ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b YAMAGATA UNIVERSITY   (Japan)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cigarette smoke; COPD; Emphysema; Free radicals; Glutathione; Glutathione reductase; Nrf2; Oxidative stress

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; MESSENGER RNA; OXIDIZING AGENT; QUINONE DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL PROTECTION; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; LUNG; MICROINJECTION; MODULATION; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEFICIENCY; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALS; CELL LINE; CELL SURVIVAL; FIBROBLASTS; GLUTATHIONE; GLUTATHIONE REDUCTASE; HYDROQUINONES; LUNG; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SMOKING; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 58649100237     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.10.040     Document Type: Article

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