Smad3-ATF3 signaling mediates TGF-β suppression of genes encoding Phase II detoxifying proteins

Free Radical Biology and Medicine

Volumn 38, Issue 3, 2005, Pages 375-387

  Bakin, Andrei V ^a   Stourman, Nina V ^a   Sekhar, Konjeti R ^b   Rinehart, Cammie ^b   Yan, Xuexian ^b   Meredith, Michael J ^c   Arteaga, Carlos L ^b   Freeman, Michael L ^b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

ATF3; Free radicals; Glutathione; Nrf2; Smad; TGF

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DETOXIFICATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SUBUNIT; FIBROSIS; GENE ACTIVITY; GENE EXPRESSION; GENE REPRESSION; GLUTATHIONE METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; CATALASE; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; METABOLIC DETOXICATION, DRUG; MICE; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 11344292584     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.10.033     Document Type: Article

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