Role of NRF2 in protection against hyperoxic lung injury in mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 26, Issue 2, 2002, Pages 175-182

  Cho, Hye Youn ^a   Jedlicka, Anne E ^a   Reddy, Sekhar P M ^a   Kensler, Thomas W ^a   Yamamoto, Masayuki ^a   Zhang, Liu Yi ^a   Kleeberger, Steven R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

ANTIOXIDANT; DNA BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; MESSENGER RNA; NFE2L2 PROTEIN, MOUSE; NUCLEAR PROTEIN; OXYGEN; TISSUE EXTRACT; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ARTICLE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; INJURY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; METABOLISM; MOUSE; MOUSE MUTANT; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; BRONCHOALVEOLAR LAVAGE FLUID; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LEUCINE ZIPPERS; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; NUCLEAR PROTEINS; OXIDATION-REDUCTION; OXYGEN; RNA, MESSENGER; TISSUE EXTRACTS; TRANS-ACTIVATORS;

EID: 0036007313     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.26.2.4501     Document Type: Article

References (42)

1. Free radicals, antioxidants, and human disease: Where are we now?
2. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen
3. Morphologic changes in pulmonary oxygen toxicity
4. Tolerance of rats to hyperoxia
5. Pulmonary oxygen toxicity: A review
6. Antioxidant enzyme expression in rat lungs during hyperoxia
7. Post-transcriptional regulation of lung antioxidant enzyme gene expression
8. Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia
9. Transgenic models for the study of lung antioxidant defense: Enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia
10. Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity
11. Gene therapy for oxidant injury-related diseases: Adenovirus-mediated transfer of superoxide dismutase and catalase cDNAs protects against hyperoxia but not against ischemia-reperfusion lung injury
12. Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury
13. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury
14. Molecular mechanisms of quinone cytotoxicity
15. Antioxidant functions of sulforaphone: A potent inducer of phase II detoxication enzymes
16. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
17. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
18. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
19. Nrf2 is essential for protection against acute pulmonary injury in mice
20. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
21. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
22. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
23. Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element
24. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice
25. Accurate quantitation of cells recovered by bronchoalveolar lavage
26. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
27. Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue
28. The human dioxin-inducible NAD(P)H: Quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4
29. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation
30. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene
31. Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcystein synthetase heavy subunit gene
32. Glutathione redox system in oxidative lung injury
33. Does lung NAD(P)H:quinone reductase (DT-diaphorase) play an antioxidant enzyme role in protection from hyperoxia?
34. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia
35. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
36. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells role of p38 kinase and Nrf2 transcription factor
37. Lipopolysaccharide activates transcription of the heme oxygenase gene in mouse M1 cells through oxidative activation of nuclear factor kappa B
38. Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: Role of reactive oxygen intermediates and AP-1
39. Tissue-specific functions of individual glutathione peroxidases
40. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
41. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
42. Role of transcriptional factor Nrf2 in the induction of hepatic phase 2 and antioxidant enzymes in vivo by the cancer chemoprotective agent, 3H-1,2-dithiole-3-thione