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Volumn 8, Issue 1-2, 2006, Pages 88-98

Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: Implications for the impact of particulate pollutants on asthma

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A6; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR KEAP1; TRANSCRIPTION FACTOR NRF2; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

EID: 33644652410     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.8.88     Document Type: Review
Times cited : (116)

References (118)
  • 1
    • 0033543566 scopus 로고    scopus 로고
    • Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    • Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, and Cook JL. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274: 26071-26078, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 26071-26078
    • Alam, J.1    Stewart, D.2    Touchard, C.3    Boinapally, S.4    Choi, A.M.5    Cook, J.L.6
  • 3
    • 0030979811 scopus 로고    scopus 로고
    • Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients
    • Antczak A, Nowak D, Shariati B, Krol M, Piasecka G, and Kurmanowska Z. Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients. Eur Respir J 10: 1235-1241, 1997.
    • (1997) Eur Respir J , vol.10 , pp. 1235-1241
    • Antczak, A.1    Nowak, D.2    Shariati, B.3    Krol, M.4    Piasecka, G.5    Kurmanowska, Z.6
  • 4
    • 0032605467 scopus 로고    scopus 로고
    • Hydrogen peroxide in expired air condensate correlates positively with early steps of peripheral neutrophil activation in asthmatic patients
    • Antczak A, Nowak D, Bialasiewicz P, and Kasielski M. Hydrogen peroxide in expired air condensate correlates positively with early steps of peripheral neutrophil activation in asthmatic patients. Arch Immunol Ther Exp (Warsz) 47: 119-126, 1999.
    • (1999) Arch Immunol Ther Exp (Warsz) , vol.47 , pp. 119-126
    • Antczak, A.1    Nowak, D.2    Bialasiewicz, P.3    Kasielski, M.4
  • 5
    • 0035875447 scopus 로고    scopus 로고
    • Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
    • Aoki Y, Sato H, Nishimura N, Takahashi S, Itoh K, and Yamamoto M. Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol 173: 154-160, 2001.
    • (2001) Toxicol Appl Pharmacol , vol.173 , pp. 154-160
    • Aoki, Y.1    Sato, H.2    Nishimura, N.3    Takahashi, S.4    Itoh, K.5    Yamamoto, M.6
  • 7
    • 0033009610 scopus 로고    scopus 로고
    • Generation of reactive oxygen species and 8-hydroxy-2′- deoxyguanosine formation from diesel exhaust particle components in L1210 cells
    • Arimoto T, Yoshikawa T, Takano T, and Kohno M. Generation of reactive oxygen species and 8-hydroxy-2′-deoxyguanosine formation from diesel exhaust particle components in L1210 cells. Jpn J Pharmacol 80: 49-54, 1999.
    • (1999) Jpn J Pharmacol , vol.80 , pp. 49-54
    • Arimoto, T.1    Yoshikawa, T.2    Takano, T.3    Kohno, M.4
  • 8
    • 0043011674 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells
    • Baulig A, Garlatti M, Marchand V, Barouki R, Marano F, and Baeza-Squiban A. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 285: L671-L679, 2003.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285
    • Baulig, A.1    Garlatti, M.2    Marchand, V.3    Barouki, R.4    Marano, F.5    Baeza-Squiban, A.6
  • 9
    • 0242666198 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
    • Bloom DA, and Jaiswal AK. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J Biol Chem 278: 44675-44682, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 44675-44682
    • Bloom, D.A.1    Jaiswal, A.K.2
  • 10
    • 0034102303 scopus 로고    scopus 로고
    • The environmental pollutant pyrene induces the production of IL-4
    • Bömmel, H, Li-Weber M, Serfling E, and Duschl A. The environmental pollutant pyrene induces the production of IL-4. J Allergy Clin Immunol 105: 796-802, 2000.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 796-802
    • Bömmel, H.1    Li-Weber, M.2    Serfling, E.3    Duschl, A.4
  • 11
    • 0036736796 scopus 로고    scopus 로고
    • Oxidative stress in allergic respiratory diseases
    • Bowler RP, and Crapo, JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol 110: 349-356, 2002.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 349-356
    • Bowler, R.P.1    Crapo, J.D.2
  • 12
    • 0037115242 scopus 로고    scopus 로고
    • Oxidative stress in airways: Is there a role for extracellular superoxide dismutase
    • Bowler RP, and Crapo JD. Oxidative stress in airways: is there a role for extracellular superoxide dismutase. Am J Respir Crit Care Med 166: S38-S43, 2002.
    • (2002) Am J Respir Crit Care Med , vol.166
    • Bowler, R.P.1    Crapo, J.D.2
  • 13
    • 3142658018 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of asthma
    • Bowler RP. Oxidative stress in the pathogenesis of asthma. Curr Allergy Asthma Rep 4: 116-122, 2004.
    • (2004) Curr Allergy Asthma Rep , vol.4 , pp. 116-122
    • Bowler, R.P.1
  • 14
    • 4143132283 scopus 로고    scopus 로고
    • Possible gene dosage effect of glutathione-S-transferases on atopic asthma: Using realtime PCR for quantification of GSTM1 and GSTT1 gene copy numbers
    • Brasch-Andersen C, Christiansen L, Tan Q, Haagerup A, Vestbo J, and Kruse TA. Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using realtime PCR for quantification of GSTM1 and GSTT1 gene copy numbers. Hum Mutat 24: 208-214, 2004.
    • (2004) Hum Mutat , vol.24 , pp. 208-214
    • Brasch-Andersen, C.1    Christiansen, L.2    Tan, Q.3    Haagerup, A.4    Vestbo, J.5    Kruse, T.A.6
  • 15
    • 1242276386 scopus 로고    scopus 로고
    • Oxidants and asthma
    • Caramori G, and Papi A. Oxidants and asthma. Thorax 59: 170-173, 2004.
    • (2004) Thorax , vol.59 , pp. 170-173
    • Caramori, G.1    Papi, A.2
  • 16
    • 13044304201 scopus 로고    scopus 로고
    • Nrf2 is essential for protection against acute pulmonary injury in mice
    • Chan K, and Kan YW. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci USA 96: 12731-12736, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12731-12736
    • Chan, K.1    Kan, Y.W.2
  • 17
    • 0035836698 scopus 로고    scopus 로고
    • An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
    • Chan K, Han XD, and Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98:4611-4616, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.D.2    Kan, Y.W.3
  • 18
    • 1242326338 scopus 로고
    • Mutigenecity of quinones: Pathways of metabolic activation and detoxification
    • Chesis PL, Levin DE, Smith MT, Ernster L, and Ames B. Mutigenecity of quinones: pathways of metabolic activation and detoxification. Proc Natl Acad Sci USA 81: 1696-1700, 1984.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 1696-1700
    • Chesis, P.L.1    Levin, D.E.2    Smith, M.T.3    Ernster, L.4    Ames, B.5
  • 19
    • 4344586383 scopus 로고    scopus 로고
    • Advances in asthma, allergy and immunology series 2004: Basic and clinical immunology
    • Chinen J, and Shearer WT. Advances in asthma, allergy and immunology series 2004: basic and clinical immunology. J Allergy Clin Immunol 114: 398-405, 2004.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 398-405
    • Chinen, J.1    Shearer, W.T.2
  • 21
    • 0343920015 scopus 로고    scopus 로고
    • Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response
    • Comhair SA, Bhathena PR, Dweik RA, Kavuru K, and Erzurum SC. Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response. Lancet 355: 624, 2000.
    • (2000) Lancet , vol.355 , pp. 624
    • Comhair, S.A.1    Bhathena, P.R.2    Dweik, R.A.3    Kavuru, K.4    Erzurum, S.C.5
  • 22
    • 0035161960 scopus 로고    scopus 로고
    • Extracellular glutathione peroxidase induction in asthmatic lungs: Evidence for redox regulation of expression in human airway epithelial cells
    • Comhair SA, Bhathena PR, Farver C, Thunnissen FB, and Erzurum SC. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J 15: 70-78, 2001.
    • (2001) FASEB J , vol.15 , pp. 70-78
    • Comhair, S.A.1    Bhathena, P.R.2    Farver, C.3    Thunnissen, F.B.4    Erzurum, S.C.5
  • 23
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3 Keapl ligase
    • Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3 Keapl ligase. Mol Cell Biol 19: 8477-8486, 2004.
    • (2004) Mol Cell Biol , vol.19 , pp. 8477-8486
    • Cullinan, S.B.1    Gordan, J.D.2    Jin, J.3    Harper, J.W.4    Diehl, J.A.5
  • 26
    • 0031092642 scopus 로고    scopus 로고
    • Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern
    • Diaz-Sanchez D, Tsien A, Fleming J, and Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol 158: 2406-2413, 1997.
    • (1997) J Immunol , vol.158 , pp. 2406-2413
    • Diaz-Sanchez, D.1    Tsien, A.2    Fleming, J.3    Saxon, A.4
  • 27
    • 0033778272 scopus 로고    scopus 로고
    • In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans
    • Diaz-Sanchez D, Jyrala M, Ng D, Nel A, and Saxon A. In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans. Clin Immunol 97: 140-145, 2000.
    • (2000) Clin Immunol , vol.97 , pp. 140-145
    • Diaz-Sanchez, D.1    Jyrala, M.2    Ng, D.3    Nel, A.4    Saxon, A.5
  • 28
    • 0035853101 scopus 로고    scopus 로고
    • Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    • Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, and Talalay P. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA 98: 3404-3409, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3404-3409
    • Dinkova-Kostova, A.T.1    Massiah, M.A.2    Bozak, R.E.3    Hicks, R.J.4    Talalay, P.5
  • 29
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, and Talalay P. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99: 11908-11913, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6    Yamamoto, M.7    Talalay, P.8
  • 30
    • 0035723661 scopus 로고    scopus 로고
    • Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha)
    • nd LJ, Murray JJ, Morrow JD, Hartert TV, and Sheller JR. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin Exp Allergy 31: 387-390, 2001.
    • (2001) Clin Exp Allergy , vol.31 , pp. 387-390
    • Dworski, R.1    Roberts II, L.J.2    Murray, J.J.3    Morrow, J.D.4    Hartert, T.V.5    Sheller, J.R.6
  • 32
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, and Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 59: 169-177, 2001.
    • (2001) Toxicol Sci , vol.59 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6    Harada, T.7    Yamamoto, M.8
  • 33
    • 0033836222 scopus 로고    scopus 로고
    • Synergistic effects of diesel organic extracts and allergen der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects
    • Fahy O, Hammad H, Senechal S, Pestel J, Tonnel AB, Wallaert B, and Tsicopoulos A. Synergistic effects of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects. Am J Respir Cell Mol Biol 23: 247-254, 2000.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 247-254
    • Fahy, O.1    Hammad, H.2    Senechal, S.3    Pestel, J.4    Tonnel, A.B.5    Wallaert, B.6    Tsicopoulos, A.7
  • 34
    • 0036604431 scopus 로고    scopus 로고
    • Diesel exposure favors Th2 cell recruitment by mononuclear cells and alveolar macrophages from allergic patients by differentially regulating macrophage-derived chemokine and IFNγ-induced protein-10 production
    • Fahy O, Senechal S, Pene J, Scherpereel A, Lassalle P, Tonnel AB, Yssel H, Wallaert B, and Tsicopoulos A. Diesel exposure favors Th2 cell recruitment by mononuclear cells and alveolar macrophages from allergic patients by differentially regulating macrophage-derived chemokine and IFNγ-induced protein-10 production. J Immunol 168: 5912-5919, 2002.
    • (2002) J Immunol , vol.168 , pp. 5912-5919
    • Fahy, O.1    Senechal, S.2    Pene, J.3    Scherpereel, A.4    Lassalle, P.5    Tonnel, A.B.6    Yssel, H.7    Wallaert, B.8    Tsicopoulos, A.9
  • 36
    • 0032161920 scopus 로고    scopus 로고
    • Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching
    • Fujieda S, Diaz-Sanchez D, and Saxon A. Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching. Am J Respir Cell Mol Biol 19: 507-512, 1998.
    • (1998) Am J Respir Cell Mol Biol , vol.19 , pp. 507-512
    • Fujieda, S.1    Diaz-Sanchez, D.2    Saxon, A.3
  • 37
    • 11144264663 scopus 로고    scopus 로고
    • BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
    • Furukawa M, and Xiong Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 25: 162-171, 2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 162-171
    • Furukawa, M.1    Xiong, Y.2
  • 38
    • 0034031911 scopus 로고    scopus 로고
    • Polymorphism at the glutathione S-transferase GSTP1 locus: A new marker for bronchial hyperresponsiveness and asthma
    • Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, and Spiteri MA. Polymorphism at the glutathione S-transferase GSTP1 locus: a new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med 161: 1437-1442, 2000.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1437-1442
    • Fryer, A.A.1    Bianco, A.2    Hepple, M.3    Jones, P.W.4    Strange, R.C.5    Spiteri, M.A.6
  • 41
    • 0035719976 scopus 로고    scopus 로고
    • Simultaneous identification of GSTP1 Ile105 → Val105 and Ala114 → Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: Studies in patients with asthma
    • Hemmingsen A, Fryer AA, Hepple M, Strange RC, and Spiteri MA. Simultaneous identification of GSTP1 Ile105 → Val105 and Ala114 → Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respir Res 2: 255-260, 2001.
    • (2001) Respir Res , vol.2 , pp. 255-260
    • Hemmingsen, A.1    Fryer, A.A.2    Hepple, M.3    Strange, R.C.4    Spiteri, M.A.5
  • 42
    • 0033571350 scopus 로고    scopus 로고
    • Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages
    • Hiura TS, Kaszubowski MP, Li N, and Nel AE. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163: 5582-5591, 1999.
    • (1999) J Immunol , vol.163 , pp. 5582-5591
    • Hiura, T.S.1    Kaszubowski, M.P.2    Li, N.3    Nel, A.E.4
  • 43
    • 0034284232 scopus 로고    scopus 로고
    • The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles
    • Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave J, and Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J Immunol 165: 2703-2711, 2000.
    • (2000) J Immunol , vol.165 , pp. 2703-2711
    • Hiura, T.S.1    Li, N.2    Kaplan, R.3    Horwitz, M.4    Seagrave, J.5    Nel, A.E.6
  • 44
    • 0000554225 scopus 로고    scopus 로고
    • Holgate ST, Samet JM, Koren HS, and Maynard RL (Eds). London, Academic Press
    • Holgate ST, Samet JM, Koren HS, and Maynard RL (Eds). Air Pollution and Health. London, Academic Press, 1998, p. 707.
    • (1998) Air Pollution and Health , pp. 707
  • 45
    • 0031872123 scopus 로고    scopus 로고
    • Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: A new marker of oxidative stress
    • Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, and Barnes PJ. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax 53: 668-672, 1998.
    • (1998) Thorax , vol.53 , pp. 668-672
    • Horvath, I.1    Donnelly, L.E.2    Kiss, A.3    Paredi, P.4    Kharitonov, S.A.5    Barnes, P.J.6
  • 46
    • 0037044791 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
    • Huang HC, Nguyen T, and Pickett CB. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 277: 42769-42774, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 42769-42774
    • Huang, H.C.1    Nguyen, T.2    Pickett, C.B.3
  • 48
    • 0037010618 scopus 로고    scopus 로고
    • Enhancement of antigen-induced eosinophilic inflammation in the airways of mast-cell deficient mice by diesel exhaust particles
    • Ichinose T, Takano H, Miyabara Y, Sadakaneo K, Sagai M, and Shibamoto T. Enhancement of antigen-induced eosinophilic inflammation in the airways of mast-cell deficient mice by diesel exhaust particles. Toxicology 180: 293-301, 2002.
    • (2002) Toxicology , vol.180 , pp. 293-301
    • Ichinose, T.1    Takano, H.2    Miyabara, Y.3    Sadakaneo, K.4    Sagai, M.5    Shibamoto, T.6
  • 49
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, and Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86, 1999.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 50
    • 1942455887 scopus 로고    scopus 로고
    • Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
    • Itoh K, Tong KI, and Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36: 1208-1213, 2004.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1208-1213
    • Itoh, K.1    Tong, K.I.2    Yamamoto, M.3
  • 51
    • 0036166672 scopus 로고    scopus 로고
    • Glutathione-S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma
    • Ivaschenko TE, Sideleva OG, and Baranov VS. Glutathione-S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma. J Mol Med 80: 39-43, 2002.
    • (2002) J Mol Med , vol.80 , pp. 39-43
    • Ivaschenko, T.E.1    Sideleva, O.G.2    Baranov, V.S.3
  • 52
    • 1942520367 scopus 로고    scopus 로고
    • Nrf2 signaling in coordinated activation of antioxidant gene expression
    • Jaiswal AK. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 36: 1199-1207, 2004.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1199-1207
    • Jaiswal, A.K.1
  • 54
    • 0025939165 scopus 로고
    • The role of free radicals in airway obstruction in asthmatic patients
    • Kanazawa H, Kurihara N, Hirata K, and Takeda T. The role of free radicals in airway obstruction in asthmatic patients. Chest 100: 1319-1322, 1991.
    • (1991) Chest , vol.100 , pp. 1319-1322
    • Kanazawa, H.1    Kurihara, N.2    Hirata, K.3    Takeda, T.4
  • 56
    • 0033533063 scopus 로고    scopus 로고
    • Altered lung antioxidant status in patients with mild asthma
    • Kelly FJ, Mudway I, Blomberg A, Frew A, and Sandstrom T. Altered lung antioxidant status in patients with mild asthma. Lancet 354: 482-483, 1999.
    • (1999) Lancet , vol.354 , pp. 482-483
    • Kelly, F.J.1    Mudway, I.2    Blomberg, A.3    Frew, A.4    Sandstrom, T.5
  • 57
    • 0038545583 scopus 로고    scopus 로고
    • Superoxide dismutases in the lung and human lung disease
    • Kinnula VL, and Crapo JD. Superoxide dismutases in the lung and human lung disease. Am J Respir Crit Care Med 167: 1600-1619, 2003.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1600-1619
    • Kinnula, V.L.1    Crapo, J.D.2
  • 58
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, and Yamamoto M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 16: 7130-7139, 2004.
    • (2004) Mol Cell Biol , vol.16 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 59
    • 0031034402 scopus 로고    scopus 로고
    • Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage
    • Kumagai Y, Arimoto T, Shinyashiki M, Shimojo N, Nakai Y, Yoshikawa Y, and Sagai M. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Free Radic Biol Med 22: 479-487, 1997.
    • (1997) Free Radic Biol Med , vol.22 , pp. 479-487
    • Kumagai, Y.1    Arimoto, T.2    Shinyashiki, M.3    Shimojo, N.4    Nakai, Y.5    Yoshikawa, Y.6    Sagai, M.7
  • 60
    • 0242663270 scopus 로고    scopus 로고
    • Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion
    • Kuppner MC, Scharner A, Milani V, Von Hesler C, Tschop KE, Heinz O, and Issels RD. Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion. Blood 102: 3668-3674, 2003.
    • (2003) Blood , vol.102 , pp. 3668-3674
    • Kuppner, M.C.1    Scharner, A.2    Milani, V.3    Von Hesler, C.4    Tschop, K.E.5    Heinz, O.6    Issels, R.D.7
  • 61
    • 0036240610 scopus 로고    scopus 로고
    • Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
    • Kwak MK, Itoh K, Yamamoto M, and Kensler TW. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 22: 2883-2892, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 2883-2892
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3    Kensler, T.W.4
  • 62
    • 5144232811 scopus 로고    scopus 로고
    • Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers
    • Kwak MK, Watabayashi N, and Kensler TW. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res 555: 133-148, 2004.
    • (2004) Mutat Res , vol.555 , pp. 133-148
    • Kwak, M.K.1    Watabayashi, N.2    Kensler, T.W.3
  • 63
    • 0346874493 scopus 로고    scopus 로고
    • Taking our breath away: Dendritic cells in the pathogenesis of asthma
    • Lambrecht BN, and Hammad H. Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat Rev Immunol 3: 994-1003, 2003.
    • (2003) Nat Rev Immunol , vol.3 , pp. 994-1003
    • Lambrecht, B.N.1    Hammad, H.2
  • 64
    • 1642282736 scopus 로고    scopus 로고
    • Cellular mechanisms of redox cell signaling: The role of cysteine modification in controlling antioxidant defenses in response to electrophilic lipid oxidation products
    • Levonen AL, landar A, Ramachandran A, Ceaser EK, Dickinson DA, Zanoni G, Morror JD, and Darley-Usmar, VM. Cellular mechanisms of redox cell signaling: the role of cysteine modification in controlling antioxidant defenses in response to electrophilic lipid oxidation products. Biochem J 378: 373-382, 2004.
    • (2004) Biochem J , vol.378 , pp. 373-382
    • Levonen, A.L.1    Landar, A.2    Ramachandran, A.3    Ceaser, E.K.4    Dickinson, D.A.5    Zanoni, G.6    Morror, J.D.7    Darley-Usmar, V.M.8
  • 65
    • 0034665324 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element
    • Li N, Venkatesan MI, Miguel A, Kaplan R, Gujuluva C, Alam J, and Nel A. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J Immunol 165: 3393-3401, 2000.
    • (2000) J Immunol , vol.165 , pp. 3393-3401
    • Li, N.1    Venkatesan, M.I.2    Miguel, A.3    Kaplan, R.4    Gujuluva, C.5    Alam, J.6    Nel, A.7
  • 66
    • 0036259255 scopus 로고    scopus 로고
    • Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter
    • Li N, Kim S, Wang M, Froines J, Siouts C, and Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal Toxicol 14: 459-486, 2002.
    • (2002) Inhal Toxicol , vol.14 , pp. 459-486
    • Li, N.1    Kim, S.2    Wang, M.3    Froines, J.4    Siouts, C.5    Nel, A.6
  • 67
    • 0037108605 scopus 로고    scopus 로고
    • Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages
    • Li N, Wang M, Oberley TD, Sempf JM, and Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol 169: 4531-4541, 2002.
    • (2002) J Immunol , vol.169 , pp. 4531-4541
    • Li, N.1    Wang, M.2    Oberley, T.D.3    Sempf, J.M.4    Nel, A.E.5
  • 68
    • 0347124795 scopus 로고    scopus 로고
    • Particulate air pollutants and asthma: A paradigm for the role of oxidative stress in PM-induced adverse health effects
    • Li N, Hao M, Phalen RF, Hinds WC, and Nel AE. Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol 3: 250-265, 2003.
    • (2003) Clin Immunol , vol.3 , pp. 250-265
    • Li, N.1    Hao, M.2    Phalen, R.F.3    Hinds, W.C.4    Nel, A.E.5
  • 71
    • 0031917147 scopus 로고    scopus 로고
    • Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients
    • Majori M, Vachier I, Godard P, Farce M, Bousquet J, and Chanez P. Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients. Eur Respir J 11: 133-138, 1998.
    • (1998) Eur Respir J , vol.11 , pp. 133-138
    • Majori, M.1    Vachier, I.2    Godard, P.3    Farce, M.4    Bousquet, J.5    Chanez, P.6
  • 72
    • 0023731036 scopus 로고
    • Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
    • Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 2: 2557-2568, 1988.
    • (1988) FASEB J , vol.2 , pp. 2557-2568
    • Maines, M.D.1
  • 74
    • 0037821802 scopus 로고    scopus 로고
    • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    • McMahon M, Itoh K, Yamamoto M, and Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278: 21592-21600, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 21592-21600
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Hayes, J.D.4
  • 76
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • Motohashi H, and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10: 549-557, 2004.
    • (2004) Trends Mol Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 78
    • 0036175036 scopus 로고    scopus 로고
    • Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging
    • Murata Y, Amao M, Yoneda J, and Hamuro J. Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging. Mol Immunol 38: 747-757, 2002.
    • (2002) Mol Immunol , vol.38 , pp. 747-757
    • Murata, Y.1    Amao, M.2    Yoneda, J.3    Hamuro, J.4
  • 79
    • 0036165578 scopus 로고    scopus 로고
    • h2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
    • h2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. Int Immunol 14: 201-212, 2002.
    • (2002) Int Immunol , vol.14 , pp. 201-212
    • Murata, Y.1    Shimamura, T.2    Hamuro, J.3
  • 80
    • 0031768649 scopus 로고    scopus 로고
    • Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system
    • Nel AE, Diaz-Sanchez D, Ng D, Hiura T, and Saxon A. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 102: 539-554, 1998.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 539-554
    • Nel, A.E.1    Diaz-Sanchez, D.2    Ng, D.3    Hiura, T.4    Saxon, A.5
  • 81
    • 0035178981 scopus 로고    scopus 로고
    • The role of particulate pollutants in pulmonary inflammation and asthma: Evidence for the involvement of organic chemicals and oxidative stress
    • Nel AE, Diaz-Sanchez D, and Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med 7: 20-26, 2001.
    • (2001) Curr Opin Pulm Med , vol.7 , pp. 20-26
    • Nel, A.E.1    Diaz-Sanchez, D.2    Li, N.3
  • 82
    • 0032528342 scopus 로고    scopus 로고
    • Macrophage activation by polycyclic aromatic hydrocarbons: Evidence for the involvement of stress-activated protein kinases, AP-1 and anti-oxidant response element
    • Ng D, Kokot N, Hiura T, Paris M, Saxon A, and Nel A. Macrophage activation by polycyclic aromatic hydrocarbons: evidence for the involvement of stress-activated protein kinases, AP-1 and anti-oxidant response element. J Immunol 161: 942-951, 1998.
    • (1998) J Immunol , vol.161 , pp. 942-951
    • Ng, D.1    Kokot, N.2    Hiura, T.3    Paris, M.4    Saxon, A.5    Nel, A.6
  • 83
    • 0035140471 scopus 로고    scopus 로고
    • Pulmonary effects of inhaled ultrafine particles
    • Oberdörster G. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74: 1-8, 2001.
    • (2001) Int Arch Occup Environ Health , vol.74 , pp. 1-8
    • Oberdörster, G.1
  • 84
    • 0032937593 scopus 로고    scopus 로고
    • Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: Generation of reactive and redox active o-quinones
    • Penning TM, Burczynski, ME, Hung CF, McCoull KD, Palackal NT, and Tsuruda LS. Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chem Res Toxicol 12: 1-18, 1999.
    • (1999) Chem Res Toxicol , vol.12 , pp. 1-18
    • Penning, T.M.1    Burczynski, M.E.2    Hung, C.F.3    McCoull, K.D.4    Palackal, N.T.5    Tsuruda, L.S.6
  • 85
    • 0035002271 scopus 로고    scopus 로고
    • Number concentration and size of particles in urban air: Effects on spirometric lung function in adult asthmatic subjects
    • Penttinen P, Timonen KL, Tiittanen T, Mirme A, Ruuskanen J, and Pekkanen J. Number concentration and size of particles in urban air: effects on spirometric lung function in adult asthmatic subjects. Environ Health Perspect 109: 319-323, 2001.
    • (2001) Environ Health Perspect , vol.109 , pp. 319-323
    • Penttinen, P.1    Timonen, K.L.2    Tiittanen, T.3    Mirme, A.4    Ruuskanen, J.5    Pekkanen, J.6
  • 86
    • 0030443305 scopus 로고    scopus 로고
    • Global increase in allergic respiratory disease: The possible role of diesel exhaust particles
    • Peterson B, and Saxon A. Global increase in allergic respiratory disease: the possible role of diesel exhaust particles. Ann Allergy Asthma Immunol 77: 263-268, 1996.
    • (1996) Ann Allergy Asthma Immunol , vol.77 , pp. 263-268
    • Peterson, B.1    Saxon, A.2
  • 87
    • 0032539920 scopus 로고    scopus 로고
    • Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
    • Peterson JD, Herzenberg LA, Vasquez K, and Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 95: 3071-3076, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3071-3076
    • Peterson, J.D.1    Herzenberg, L.A.2    Vasquez, K.3    Waltenbaugh, C.4
  • 88
    • 0000840510 scopus 로고    scopus 로고
    • Epidemiology of particle effects
    • London, England: Academic Press
    • Pope CA, and Dockery DW. Epidemiology of particle effects. Air Pollution and Health. London, England: Academic Press, 1998, p. 673.
    • (1998) Air Pollution and Health , pp. 673
    • Pope, C.A.1    Dockery, D.W.2
  • 90
    • 0029411321 scopus 로고
    • Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
    • Prestera T, Talalay P, Alam J, Ahn YI, Lee PJ, and Choi AM. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1: 827-837, 1995.
    • (1995) Mol Med , vol.1 , pp. 827-837
    • Prestera, T.1    Talalay, P.2    Alam, J.3    Ahn, Y.I.4    Lee, P.J.5    Choi, A.M.6
  • 92
    • 0345435976 scopus 로고    scopus 로고
    • Reactive oxygen species activate human peripheral blood dendritic cells
    • Rutault K, Alderman C, Chain BM, and Katz DR. Reactive oxygen species activate human peripheral blood dendritic cells. Free Radic Biol Med 26: 232-238, 1999.
    • (1999) Free Radic Biol Med , vol.26 , pp. 232-238
    • Rutault, K.1    Alderman, C.2    Chain, B.M.3    Katz, D.R.4
  • 93
    • 0005312032 scopus 로고    scopus 로고
    • Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma-like symptoms in mice
    • Sagai M, Furuyama A, and Ichinose T. Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma-like symptoms in mice. Free Radic Biol Med 21: 199-209, 1996.
    • (1996) Free Radic Biol Med , vol.21 , pp. 199-209
    • Sagai, M.1    Furuyama, A.2    Ichinose, T.3
  • 94
    • 0031857283 scopus 로고    scopus 로고
    • Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: Effect of inhaled glucocorticoid
    • Saleh D, Ernst P, Lim S, Barnes PJ, and Giaid A. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J 12: 929-937, 1998.
    • (1998) FASEB J , vol.12 , pp. 929-937
    • Saleh, D.1    Ernst, P.2    Lim, S.3    Barnes, P.J.4    Giaid, A.5
  • 96
    • 0034649702 scopus 로고    scopus 로고
    • Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994
    • Samet JM, Dominici F, Curriero FC, Coursac I, and Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med 343: 1742-1749, 2000.
    • (2000) N Engl J Med , vol.343 , pp. 1742-1749
    • Samet, J.M.1    Dominici, F.2    Curriero, F.C.3    Coursac, I.4    Zeger, S.L.5
  • 97
    • 0019359134 scopus 로고
    • The identification of polynuclear aromatic hydrocarbon (PAH) derivatives in mutagenic fractions of diesel particulate extracts
    • Schuetzle D, Lee FS, and Prater TJ. The identification of polynuclear aromatic hydrocarbon (PAH) derivatives in mutagenic fractions of diesel particulate extracts. Int J Environ Anal Chem 9: 93-144, 1981.
    • (1981) Int J Environ Anal Chem , vol.9 , pp. 93-144
    • Schuetzle, D.1    Lee, F.S.2    Prater, T.J.3
  • 98
    • 0037015682 scopus 로고    scopus 로고
    • Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by K1AA0132, the human homolog to 1Nrf2
    • Sekhar KR, Yan XX, and Freeman ML. Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by K1AA0132, the human homolog to 1Nrf2. Oncogene 21: 6829-6834, 2002.
    • (2002) Oncogene , vol.21 , pp. 6829-6834
    • Sekhar, K.R.1    Yan, X.X.2    Freeman, M.L.3
  • 100
    • 0033946186 scopus 로고    scopus 로고
    • Polymorphisms at the glutathione S-transferase, GSTP1 locus: A novel mechanism for susceptibility and development of atopic airway inflammation
    • Spiteri MA, Bianco A, Strange RC, and Fryer AA. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy 55 (Suppl 61): 15-20, 2000.
    • (2000) Allergy , vol.55 , Issue.SUPPL. 61 , pp. 15-20
    • Spiteri, M.A.1    Bianco, A.2    Strange, R.C.3    Fryer, A.A.4
  • 101
    • 0037462651 scopus 로고    scopus 로고
    • Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
    • Stewart D, Killeen E, Naquin R, Alam S, and Alam J. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem 278: 2396-2402, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 2396-2402
    • Stewart, D.1    Killeen, E.2    Naquin, R.3    Alam, S.4    Alam, J.5
  • 103
    • 0030785642 scopus 로고    scopus 로고
    • Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice
    • Takano H, Yoshikawa T, Ichinose T, Miyabara Y, Imaoka K, and Sagai M. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med 156: 36-42, 1997.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 36-42
    • Takano, H.1    Yoshikawa, T.2    Ichinose, T.3    Miyabara, Y.4    Imaoka, K.5    Sagai, M.6
  • 104
  • 105
    • 0028801973 scopus 로고
    • Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: Direct effects on B-cell IgE production
    • Takenaka H, Zhang K, Diaz-Sanchez D, Tsien A, and Saxon A. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B-cell IgE production. J Allergy Clin Immunol 95: 103-115, 1995.
    • (1995) J Allergy Clin Immunol , vol.95 , pp. 103-115
    • Takenaka, H.1    Zhang, K.2    Diaz-Sanchez, D.3    Tsien, A.4    Saxon, A.5
  • 112
    • 0347379850 scopus 로고    scopus 로고
    • Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particles in a macrophage cell line
    • Xiao GG, Wang M, Li N, Loo JA, and Nel AE. Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particles in a macrophage cell line. J Biol Chem 278: 50781-50790, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 50781-50790
    • Xiao, G.G.1    Wang, M.2    Li, N.3    Loo, J.A.4    Nel, A.E.5
  • 113
    • 0033925281 scopus 로고    scopus 로고
    • Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema
    • Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, and Sasaki H. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66: 187-195, 2000.
    • (2000) Am J Hum Genet , vol.66 , pp. 187-195
    • Yamada, N.1    Yamaya, M.2    Okinaga, S.3    Nakayama, K.4    Sekizawa, K.5    Shibahara, S.6    Sasaki, H.7
  • 115
    • 8444247862 scopus 로고    scopus 로고
    • Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles
    • Yin XJ, Ma JYC, Antonini JM, Castranova V, and Ma JKH. Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles. Toxicol Sci 82: 143-153, 2004.
    • (2004) Toxicol Sci , vol.82 , pp. 143-153
    • Yin, X.J.1    Ma, J.Y.C.2    Antonini, J.M.3    Castranova, V.4    Ma, J.K.H.5
  • 117
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • Zhang DD, and Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23: 8137-8151, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 118
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a cul3-dependent ubiquitin ligase complex
    • Zhang DD, Lo SC, Cross JV, Templeton DJ, and Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24: 10941-10953, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5


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