Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

Kidney International

Volumn 76, Issue 3, 2009, Pages 277-285

  Liu, Manchang ^a   Grigoryev, Dmitry N ^a   Crow, Michael T ^a   Haas, Mark ^a   Yamamoto, Masayuki ^b   Reddy, Sekhar P ^c   Rabb, Hamid ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acute kidney injury; Antioxidant; Cisplatin; Ischemia reperfuion; Nephrotoxicity; Transcription factor Nrf2

Indexed keywords

ACETYLCYSTEINE; CHEMOKINE; CISPLATIN; CYTOKINE; GLUTATHIONE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CISPLATIN INDUCED NEPHROTOXICITY; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; ISCHEMIA REPERFUSION INJURY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TUBULE DISORDER; KNOCKOUT MOUSE; MORTALITY; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SURVIVAL; UPREGULATION; WILD TYPE;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; CAPILLARY PERMEABILITY; CISPLATIN; GLUTATHIONE; INFLAMMATION MEDIATORS; KIDNEY; KIDNEY FUNCTION TESTS; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RENAL INSUFFICIENCY, ACUTE; REPERFUSION INJURY; UP-REGULATION;

EID: 67651124846     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.157     Document Type: Article

References (40)

1. Molitoris BA. Ischemic acute renal failure: exciting times at our fingertips. Curr Opin Nephrol Hypertens 1998; 7: 405-406.
2. Terasaki PI, Cecka JM, Gjertson DW et al. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995; 333: 333-336.
3. Star RA. Treatment of acute renal failure. Kidney Int 1998; 54: 1817-1831.
4. Schetz M, Dasta J, Goldstein S et al. Drug-induced acute kidney injury. Curr Opin Crit Care 2005; 11: 555-565.
5. Thimmulappa RK, Lee H, Rangasamy T et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 2006; 116: 984-995.
6. Thimmulappa RK, Scollick C, Traore K et al. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDOImidazolide. Biochem Biophys Res Commun 2006; 351: 883-889.
7. Cho HY, Jedlicka AE, Reddy SP et al. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 2002; 26: 175-182.
8. Cho HY, Reddy SP, Debiase A et al. Gene expression profiling of NRF2- mediated protection against oxidative injury. Free Radic Biol Med 2005; 38: 325-343.
9. Cho HY, Reddy SP, Yamamoto M et al. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004; 18: 1258-1260.
10. Rangasamy T, Guo J, Mitzner WA et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 2005; 202: 47-59.
11. Rangasamy T, Cho CY, Thimmulappa RK et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004; 114: 1248-1259.
12. Shih AY, Li P, Murphy TH. A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 2005; 25: 10321-10335.
13. Zhao J, Kobori N, Aronowski J et al. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 2006; 393: 108-112.
14. Leonard MO, Kieran NE, Howell K et al. Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J 2006; 20: 2624-2626.
15. Hirayama A, Nagase S, Ueda A et al. In vivo imaging of oxidative stress in ischemia-reperfusion renal injury using electron paramagnetic resonance. Am J Physiol Renal Physiol 2005; 288: F597-F603.
16. Zaman MB, Leonard MO, Ryan EJ et al. Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemiareperfusion injury? Transplantation 2007; 84: 1272-1278.
17. Reddy NM, Kleeberger SR, Yamamoto M et al. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics 2007; 32: 74-81.
18. Nitescu N, Ricksten SE, Marcussen N et al. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion. Nephrol Dial Transplant 2006; 21: 1240-1247.
19. Sehirli AO, Sener G, Satiroglu H et al. Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat. J Nephrol 2003; 16: 75-80.
20. DiMari J, Megyesi J, Udvarhelyi N et al. N-acetyl cysteine ameliorates ischemic renal failure. Am J Physiol 1997; 272: F292-F298.
21. Di GC, Pinheiro HS, Heinke T et al. Beneficial effect of N-acetyl-cysteine on renal injury triggered by ischemia and reperfusion. Transplant Proc 2006; 38: 2774-2776.
22. de Araujo M, Andrade L, Coimbra TM et al. Magnesium supplementation combined with N-acetylcysteine protects against postischemic acute renal failure. J Am Soc Nephrol 2005; 16: 3339-3349.
23. Pincemail J, Defraigne JO, Detry O et al. Ischemia-reperfusion injury of rabbit kidney: comparative effects of desferrioxamine and N-acetylcysteine as antioxidants. Transplant Proc 2000; 32: 475-476.
24. Baranska-Kosakowska A, Zakliczynski M, Przybylski R et al. Role of N-acetylcysteine on renal function in patients after orthotopic heart transplantation undergoing coronary angiography. Transplant Proc 2007; 39: 2853-2855.
25. Wijeysundera DN, Beattie WS, Rao V et al. N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency. Can J Anaesth 2007; 54: 872-881.
26. Macedo E, Abdulkader R, Castro I et al. Lack of protection of N-acetylcysteine (NAC) in acute renal failure related to elective aortic aneurysm repair-a randomized controlled trial. Nephrol Dial Transplant2006; 21: 1863-1869.
27. Itoh K, Chiba T, Takahashi S et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 1997; 236: 313-322.
28. Ishii T, Itoh K, Takahashi S et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 2000; 275: 16023-16029.
29. Alam J, Killeen E, Gong P et al. Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am J Physiol Renal Physiol2003; 284: F743-F752.
30. Stewart D, Killeen E, Naquin R et al. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem 2003; 278: 2396-2402.
31. Molls RR, Savransky V, Liu M et al. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol2006; 290: F1187-F1193.
32. Rabb H, Ramirez G, Saba SR et al. Renal ischemic-reperfusion injury in L-selectin-deficient mice. Am J Physiol 1996; 271: F408-F413.
33. Liu M, Chien CC, Burne-Taney M et al. A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol2006; 17: 765-774.
34. Kelly KJ, Williams Jr WW, Colvin RB et al. Intercellular adhesion molecule- 1-deficient mice are protected against ischemic renal injury. J Clin Invest1996; 97: 1056-1063.
35. Carattino MD, Cueva F, Zuccollo A et al. Renal ischemia-induced increase in vascular permeability is limited by hypothermia. Immunopharmacology1999; 43: 241-248.
36. Grigoryev DN, Ma SF, Simon BA et al. In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip technology. BMC Genomics 2005; 6: 62.
37. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116-5121.
38. Hensley K, Fedynyshyn J, Ferrell S et al. Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis 2003; 14: 74-80.
39. Reddy NM, Kleeberger SR, Cho HY et al. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am J Respir Cell Mol Biol 2007; 37: 3-8.
40. Leeuwenburgh C, Ji LL. Glutathone and glutathione ethyl ester supplementation of mice alter glutathione homeostasis during exercise. J Nutr 1998; 128: 2420-2426.