Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: Degradation of Nrf2 by the 26 S proteasome

Journal of Biological Chemistry

Volumn 278, Issue 7, 2003, Pages 4536-4541

  Nguyen, Truyen ^a,b   Sherratt, Philip J ^a   Huang, H C ^a   Yang, Chung S ^b   Pickett, Cecil B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYMES; GENES; METABOLISM;

ANTIOXIDANTS;

PROTEINS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA NAPHTHOFLAVONE; CHLORAMPHENICOL ACETYLTRANSFERASE; LACTACYSTIN; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN KINASE C; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NF E2; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 2-TERT-BUTYLHYDROQUINONE; ANTIOXIDANT; ATP DEPENDENT 26S PROTEASE; DNA BINDING PROTEIN; ENZYME INHIBITOR; FLAVONOID; HYDROQUINONE DERIVATIVE; LEUCINE ZIPPER PROTEIN; NFE2L2 PROTEIN, HUMAN; NITRILE; PEPTIDE HYDROLASE; PROTEIN SUBUNIT; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE ACTIVATION; GENE ACTIVITY; GENE CONSTRUCT; GENE INDUCTION; GENETIC CODE; GENETIC TRANSCRIPTION; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TRANSPORT; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION; CELL LINE; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; RNA PROCESSING;

ANIMALIA; PHOS;

ANTIOXIDANTS; BETA-NAPHTHOFLAVONE; BUTADIENES; CELL LINE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; HYDROQUINONES; LEUCINE ZIPPERS; NF-E2-RELATED FACTOR 2; NITRILES; OXIDATIVE STRESS; PEPTIDE HYDROLASES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0013282861     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207293200     Document Type: Article

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