Protein aggregation diseases: Pathogenicity and therapeutic perspectives

Nature Reviews Drug Discovery

Volumn 9, Issue 3, 2010, Pages 237-248

  Aguzzi, Adriano ^a   O'Connor, Tracy ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE INHIBITOR; CHLOROQUINE; FLURBIPROFEN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; LYMPHOTOXIN BETA RECEPTOR; MEPACRINE; NOTCH RECEPTOR; OLIGOMER; PRION PROTEIN;

ACTIVE IMMUNIZATION; ALZHEIMER DISEASE; AMYLOIDOSIS; BLOOD BRAIN BARRIER; CLINICAL TRIAL; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; DRUG MECHANISM; DRUG TARGETING; GASTROINTESTINAL TOXICITY; HUMAN; IMMUNOTHERAPY; IMMUNOTOXICITY; LIPID RAFT; MENINGOENCEPHALITIS; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; REVIEW; THEORY; TRANSGENE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; AMYLOIDOSIS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOTHERAPY; PEPTIDES; PRION DISEASES;

EID: 77649202326     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3050     Document Type: Review

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