Intraneuronal Aβ42 accumulation in human brain

American Journal of Pathology

Volumn 156, Issue 1, 2000, Pages 15-20

  Gouras, Gunnar K ^a,b   Tsai, Julia ^b   Naslund, Jan ^a   Vincent, Bruno ^a   Edgar, Mark ^c   Checler, Frederic ^d   Greenfield, Jeffrey P ^a   Haroutunian, Vahram ^b   Buxbaum, Joseph D ^b   Xu, Huaxi ^a   Greengard, Paul ^a   Relkin, Norman R ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ADULT; AGED; ARTICLE; BRAIN; CADAVER; COGNITIVE DEFECT; DEMENTIA; DOWN SYNDROME; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; METABOLISM; MIDDLE AGED; NERVE CELL; NEUROFIBRILLARY TANGLE; PATHOLOGY; PSYCHOLOGICAL ASPECT; REFERENCE VALUE; SENILE PLAQUE; ALZHEIMER DISEASE; CHILD; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE MICROSCOPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECRETION;

ADULT; AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN; BRAIN; CADAVER; COGNITION DISORDERS; DEMENTIA; DOWN SYNDROME; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MIDDLE AGED; NEUROFIBRILLARY TANGLES; NEURONS; PEPTIDE FRAGMENTS; REFERENCE VALUES; SENILE PLAQUES;

EID: 0033622324     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64700-1     Document Type: Article

References (28)

1. The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
2. Visualization of A β 42(43) and A β 40 in senile plaques with end-specific A β monoclonals: Evidence that an initially deposited species is A β 42(43)
3. Sequence of deposition of heterogeneous amyloid β-peptides and APO E in Down syndrome: Implications for initial events in amyloid plaque formation
4. Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
5. Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42
6. Detection of a novel intraneuronal pool of insoluble amyloid β protein that accumulates with time in culture
7. Distinct sites of intracellular production for Alzheimer's disease A β40/42 amyloid peptides
8. Alzheimer's A β(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
9. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
10. Mutagenesis identifies new signals for β-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
11. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
12. Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease β-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system
13. Polyclonals to β-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum
14. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization
15. Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
16. A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles
17. Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease
18. Perforant pathway changes and the memory impairment of Alzheimer's disease
19. Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases
20. Generation and regulation of amyloid-β peptide variants in neurons
21. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
22. Dominant and differential deposition of distinct β-amyloid peptide species, A β N3(pE), in senile plaques
23. Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
24. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
25. Plaque-independent disruption of neural circuits in Alzheimer's disease mcuse models
26. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
27. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition